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Keywords: Osteosarcoma
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Articles
Biosci Rep (2022) 42 (6): BSR20220040.
Published: 09 June 2022
...% of osteosarcomas. Their data significantly correlated with poor neoadjuvant response. These authors emphasize a shorter progression-free and overall survival of the patients demonstrating an altered expression of this gene. Interestingly, mRNA in silico analysis established that SMARCB1 expression correlates...
Articles
Biosci Rep (2022) 42 (1): BSR20212446.
Published: 11 January 2022
... and clinical significance in osteosarcoma remain unknown. The aim of the present study was to investigate SMARCB1 expression in osteosarcoma and its clinical significance with respect to chemosensitivity and prognosis. Methods: We obtained 114 specimens from 70 osteosarcoma patients to construct a tissue...
Articles
Biosci Rep (2021) 41 (8): BSR20210952.
Published: 06 August 2021
...-tubulin. This compound induces accumulation of acetylated tubulin and cytotoxicity in multiple myeloma (MM) cells. In this journal, Sun et al. ( Biosci. Rep. 41 , DOI: 10.1042/BSR20203905) identified that WT161 suppresses the cell growth of osteosarcoma cells. This discovery opens the door to future...
Articles
Biosci Rep (2021) 41 (4): BSR20203905.
Published: 30 April 2021
... of cancers. The aim of the present study is to explore the roles of WT161 in osteosarcoma and its underlying mechanisms. Methods: The anti-proliferative effect of WT161 on osteosarcoma cells was examined using MTT assay and colony formation assay. Cell apoptosis was analyzed using flow cytometer...
Articles
Biosci Rep (2021) 41 (4): BSR-20160542_RET.
Published: 16 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation...
Articles
Biosci Rep (2021) 41 (1): BSR20202505.
Published: 05 January 2021
..., medroxyprogesterone acetate and valproic acid on human osteosarcoma cells, i.e., SAOS2 and MG63 compared with their normal cell counterparts, i.e. mesenchymal stem/stromal cells (MSCs). Cell growth, viability and migration were measured by biochemical assay and live cell imaging, whilst levels of lipid-synthesising...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (12): BSR20201529.
Published: 14 December 2020
...Bin Liu; Shuqiang Yao; Jiping Zhou Osteosarcoma (OS) is the most common bone malignancy in both children and adolescents. In the present study, we aimed to explore the association of miRNA-122 and miRNA-96 expression with the clinical characteristics and prognosis of patients with osteosarcoma...
Articles
Biosci Rep (2020) 40 (9): BSR-20171615_RET.
Published: 16 September 2020
... request. CTNNB1 Invasion MicroRNA-340 Notch signaling pathway Osteosarcoma Proliferation © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0...
Articles
Biosci Rep (2020) 40 (8): BSR-20160542_EOC.
Published: 21 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation...
Articles
Biosci Rep (2020) 40 (7): BSR-20180372_EOC.
Published: 29 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . migration miR-24 osteosarcoma proliferation von Willebrand factor...
Articles
Biosci Rep (2020) 40 (7): BSR-20160542_COR.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation...
Articles
Biosci Rep (2020) 40 (6): BSR20191552.
Published: 23 June 2020
...Li Li; Xiang-an Kong; Mousheng Zang; Jisheng Dong; Yingqi Feng; Binjie Gui; Yong Hu Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Circular RNAs (circRNAs) are a type of endogenous noncoding RNA that have been verified to participate in cancer pathophysiological...
Articles
Biosci Rep (2020) 40 (6): BSR20193404.
Published: 10 June 2020
...Lei Wang Osteosarcoma (OS) is a common malignant bone cancer. Lactate dehydrogenase B (LDHB) has been revealed to act as a tumor promoter in several cancers. It is also revealed to be correlated with poor prognosis in OS, but its molecular mechanism in OS remains veiled. Our work illustrated...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20201232.
Published: 09 June 2020
...Junjie Wang; Jiangdong Ni; Deye Song; Muliang Ding; Jun Huang; Wenzhao Li; Guangxu He Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase...
Articles
Biosci Rep (2020) 40 (1): BSR20191251.
Published: 06 January 2020
...Tang Ying; Jin-ling Dong; Cen Yuan; Peng Li; Qingshan Guo Background: Osteosarcoma is the most common primary bone malignancy in children and adolescents. In order to find factors related to its recurrence, and thus improve recovery prospects, a powerful clinical signature is needed. Long noncoding...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (12): BSR20192590.
Published: 20 December 2019
...Jian Zheng; Xiaopin Yuan; Weichun Guo We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between...
Articles
Biosci Rep (2019) 39 (11): BSR20170080.
Published: 15 November 2019
... and prognosis. miR-199a has been shown to be dysregulated in multiple tumour types. However, the association between miR-199a and the chemoresistance features of osteosarcoma are not well understood, the target genes for miR-199a and the regulatory mechanisms are also unknown. In the present study, we...
Articles
Biosci Rep (2019) 39 (11): BSR20190291.
Published: 12 November 2019
...Menglin Cong; Rui Jing Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis. LncRNA tumor suppressor candidate 7 (TUSC-7) was shown to be a tumor suppressor in osteosarcoma. However, the regulation mechanism of TUSC-7 in osteosarcoma is unknown...
Articles
Biosci Rep (2019) 39 (11): BSR20192134.
Published: 12 November 2019
...Yin Tang; Zhiqian Gu; Youwei Fu; Junjie Wang Background: Chemokine receptors have a crucial role in regulating tumor mediating immunity and are also implicated in the prognosis of some cancers. Here, the association between CXC chemokine receptors (CXCR2–5) and prognosis in osteosarcoma was studied...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (8): BSR20191237.
Published: 23 August 2019
...Hua Zhang; Jidong Zhang; Fanrui Meng; Hanzhong Zhu; Hongyu Yan; Yunliang Guo; Shandi Zhang Osteosarcoma (OS) is the most frequent primary bone malignancy and affects adolescents and young adults. Recently dysregulation of miRNAs has received more attention because of its extensive role in OS...
Articles
Biosci Rep (2019) 39 (7): BSR20182200.
Published: 29 July 2019
...Qiang Huang; Shu-yan Shi; Hai-bo Ji; Shu-xing Xing Aim: In previous studies, numerous dysregulated long non-coding RNAs (lncRNAs) were identified by RNA-sequencing (RNA-seq). However, the relationship between lncRNA and osteosarcoma remains unclear. In the present study, the function and mechanism...
Articles
Biosci Rep (2019) 39 (7): BSR20190954.
Published: 19 July 2019
...Jian Zhou; Xia Xiao; Wanchun Wang; Yingquan Luo Previous studies indicated the prognostic value of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in osteosarcoma (OS). There was a great degree of inconsistency between these reports. The aim of this meta-analysis was to investigate...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (6): BSR20182366.
Published: 04 June 2019
...Yu Mu; Lina Zhang; Xue Chen; Si Chen; Yuanyuan Shi; Junfeng Li Osteosarcoma is the most common malignant tumor of bone with a high potential for metastasis. Importantly, microRNA-27a (miR-27a) is involved in the progression of osteosarcoma. The present study aims to discuss the effects of miR-27a...
Articles
Biosci Rep (2019) 39 (5): BSR20181514.
Published: 17 May 2019
...Yizhe Xi; Mitra Fowdur; Yun Liu; Hao Wu; Maolin He; Jinmin Zhao Aim: This research aims to investigate the expression profile of circRNA in osteosarcoma and to identify the underlying pathogenesis core genes of osteosarcoma. Methods : Illumina HiSeq was used to screen differentially expressed...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (5): BSR20190612.
Published: 03 May 2019
...Weidong He; Ming Lu; Dongbo Xiao The dysregulated expression of LSINCT5 (long stress-induced non-coding transcript 5) has been found in various human tumors, and was generally related to cancer progression and unfavorable prognosis. Although the role of LSINCT5 in osteosarcoma was reported not long...
Articles
Biosci Rep (2019) 39 (4): BSR20190447.
Published: 30 April 2019
...Si Chen; Weiguo Li; Ai Guo lncRNA LOXL1 antisense RNA 1 (lncRNA LOXL1-AS1) was recently found to function as oncogenic lncRNA in glioblastoma, prostate cancer, and medulloblastoma. The role of LOXL1-AS1 in osteosarcoma was still unknown. In our study, we found LOXL1-AS1 expression levels were...
Articles
Biosci Rep (2019) 39 (4): BSR20190410.
Published: 26 April 2019
...Haiyang Yu; Hang Song; Li Liu; Shuo Hu; Yuxin Liao; Gang Li; Xiao Xiao; Xin Chen; Shisheng He Osteosarcoma (OS) is recognized as a common malignant tumor with a high trend of metastasis and diffusion. Despite the progresses that have been made in surgery, chemotherapy, and radiotherapy...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (2): BSR20181283.
Published: 08 February 2019
...Haopeng Lin; Xiaodong Zheng; Ting Lu; Yang Gu; Canhao Zheng; Huajie Yan Having a better grasp of the molecular mechanisms underlying carcinogenesis and progression in osteosarcoma would be helpful to find novel therapeutic targets. Different types of cancers have presented abnormal expression...
Articles
Biosci Rep (2019) 39 (1): BSR20181707.
Published: 15 January 2019
...Dawei Yang; Hao Zhang; Jianjun Wu; Ruishuang Ma; Zongyu Li; Kunzheng Wang; Fan Yang Background: Osteosarcoma (OS) is the most common malignant neoplasm in children and adolescents with a very high propensity for local invasion and poor response to current therapy. Anti-cancer effect...
Articles
Biosci Rep (2018) 38 (6): BSR20181501.
Published: 14 December 2018
...Bin Liu; Liang Xu; E-Nuo Dai; Jia-Xin Tian; Jian-Min Li Osteosarcoma (OS) is the most common primary malignancy of skeleton with higher mortality rates amongst children and young adults worldwide, whereas effective and secure therapies have also been sought by researches with ongoing efforts...
Articles
Biosci Rep (2018) 38 (6): BSR20181384.
Published: 21 November 2018
...Xiong Wang; Lei Zhang; Wenji Wang; Yuchen Wang; Ye Chen; Ruimin Xie; Xiang Li; Yongping Wang Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found...
Articles
Biosci Rep (2018) 38 (6): BSR20180372.
Published: 16 November 2018
...Ling Liu; Jun Pan; Huan Wang; Zhenni Ma; Jie Yin; Feng Yuan; Quanwen Yuan; Lu Zhou; Xiaofeng Liu; Yu Zhang; Zhaohua Bao; Huilin Yang; Jing Ling von Willebrand factor (vWF) is a major procoagulant molecule that was shown to differentiate between metastatic and primary osteosarcoma (OS) tissues...
Articles
Biosci Rep (2018) 38 (6): BSR20181498.
Published: 16 November 2018
... unknown in osteosarcoma (OS). In our study, BDNF-AS expression was found to be decreased in OS tissues and cells. Moreover, BDNF-AS low expression was correlated with advanced Enneking stage, large tumor size and poor prognosis in OS patients. The multivariate analysis suggested low expression of BDNF...
Articles
Biosci Rep (2018) 38 (5): BSR20181171.
Published: 10 October 2018
... function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated...
Articles
Biosci Rep (2018) 38 (4): BSR20171615.
Published: 31 August 2018
...Bao-Long Pan; Ling Wu; Li Pan; Yu-Xi Yang; Hu-Huan Li; Yan-Juan Dai; Zi-Qian He; Ling Tan; You-Guang Huang; Zong-Wu Tong; Jun-Long Liao Osteosarcoma (OS) is the most common histological form of primary bone cancer. It is most prevalent in teenagers and young adults. The present study aims...
Articles
Biosci Rep (2018) 38 (4): BSR20180351.
Published: 29 August 2018
...Zhi-Wei Tao; Ping-An Zou Osteosarcoma is a disease prone to recurrence and metastasis, and adenovirus expression vector is frequently studied as a therapeutic target of osteosarcoma in recent years. The present study attempts to explore the effect of adenovirus-mediated siRNA targetting ezrin...
Articles
Biosci Rep (2018) 38 (4): BSR20171675.
Published: 13 July 2018
...Shuai Lv; Meng Guan Previous literatures have reported the role of human micro RNA-1284 (hsa-miR-1284, in short miR-1284) in diverse cancers. However, its biological function in osteosarcoma pathogenesis remains unknown. In the present study, we investigated the potential role of miR-1284...
Articles
Biosci Rep (2018) 38 (3): BSR20180078.
Published: 12 June 2018
...Liang Xi; Yongfeng Zhang; Shengnan Kong; Wei Liang miR-34 was reported to be involved in multiple tumors occurrence and development. The aim of the present study was to explore the impact of miR-34 on osteosarcoma and related mechanisms. Tumor tissues and non-tumor tissues of 34 patients...
Articles
Biosci Rep (2018) 38 (3): BSR20180375.
Published: 31 May 2018
... to be an oncogene to promote tumor growth and metastasis of many cancers. However, the clinical significance and function of NEAT1 in osteosarcoma (OS) remain to be discovered. We here collected OS tissues ( n =40) and adjacent non-tumor tissues ( n =20) to determine the expression of NEAT1 and its clinical...
Articles
Biosci Rep (2018) 38 (2): BSR20170339.
Published: 21 March 2018
...Hao Zhang; Qian-Yun He; Guang-Chao Wang; Da-Ke Tong; Ren-Kai Wang; Wen-Bin Ding; Cheng Li; Qiang Wei; Chen Ding; Pei-Zhao Liu; Hao-Chen Cui; Xin Zhang; Di Li; Hao Tang; Fang Ji Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. However, the underlying...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (3): BSR20160542.
Published: 17 May 2017
...Xi Xie; Yu-Sheng Li; Wen-Feng Xiao; Zhen-Han Deng; Hong-Bo He; Qing Liu; Wei Luo Osteosarcoma (OS) is an aggressive malignant mesenchymal neoplasm amongst adolescents. The aim of the present study was to explore the various modes of action that miR-379 has on the proliferation, migration...
Articles
Biosci Rep (2016) 36 (6): e00405.
Published: 08 November 2016
... on osteosarcoma (OS) have not been well understood. The present study aimed to test whether CuE could inhibit growth and invasion of OS cells and reveal its underlying molecular mechanism. After various concentrations of CuE treatment, the anti-proliferative effect of CuE was assessed using the cell counting Kit...
Includes: Supplementary data