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Keywords: Osteosarcoma
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Articles

Retraction: SMARCB1 expression is a novel diagnostic and prognostic biomarker for osteosarcoma

Journal: Bioscience Reports
Biosci Rep (2023) 43 (11): BSR-2021-2446_RET.
https://doi.org/10.1042/BSR-2021-2446_RET
Published: 03 November 2023
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Biomarker Immunohistochemistry Osteosarcoma Prognosis Tissue microarray ...
View article titled, Retraction: SMARCB1 expression is a novel diagnostic and prognostic biomarker for <span class="search-highlight">osteosarcoma</span>
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Articles

Expression of Concern: Adenovirus small interfering RNA targeting ezrin induces apoptosis and inhibits metastasis of human osteosarcoma MG-63 cells

Journal: Bioscience Reports
Biosci Rep (2023) 43 (7): BSR-2018-0351_EOC.
https://doi.org/10.1042/BSR-2018-0351_EOC
Published: 21 July 2023
... Osteosarcoma Proliferation The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. It has been noted that The Empty vector panel in Figure 8A...
View article titled, Expression of Concern: Adenovirus small interfering RNA targeting ezrin induces apoptosis and inhibits metastasis of human <span class="search-highlight">osteosarcoma</span> MG-63 cells
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Articles

Commentary on: SMARCB1 as a novel diagnostic and prognostic biomarker for osteosarcoma

Consolato M. Sergi
Journal: Bioscience Reports
Biosci Rep (2022) 42 (6): BSR20220040.
https://doi.org/10.1042/BSR20220040
Published: 09 June 2022
...% of osteosarcomas. Their data significantly correlated with poor neoadjuvant response. These authors emphasize a shorter progression-free and overall survival of the patients demonstrating an altered expression of this gene. Interestingly, mRNA in silico analysis established that SMARCB1 expression correlates...
View article titled, Commentary on: SMARCB1 as a novel diagnostic and prognostic biomarker for <span class="search-highlight">osteosarcoma</span>
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Articles

SMARCB1 expression is a novel diagnostic and prognostic biomarker for osteosarcoma

Tao Guo, Ran Wei, Dylan C. Dean, Francis J. Hornicek, Zhenfeng Duan
Journal: Bioscience Reports
Biosci Rep (2022) 42 (1): BSR20212446.
https://doi.org/10.1042/BSR20212446
Published: 11 January 2022
... and clinical significance in osteosarcoma remain unknown. The aim of the present study was to investigate SMARCB1 expression in osteosarcoma and its clinical significance with respect to chemosensitivity and prognosis. Methods: We obtained 114 specimens from 70 osteosarcoma patients to construct a tissue...
View article titled, SMARCB1 expression is a novel diagnostic and prognostic biomarker for <span class="search-highlight">osteosarcoma</span>
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Articles

Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

Consolato M. Sergi
Journal: Bioscience Reports
Biosci Rep (2021) 41 (8): BSR20210952.
https://doi.org/10.1042/BSR20210952
Published: 06 August 2021
...-tubulin. This compound induces accumulation of acetylated tubulin and cytotoxicity in multiple myeloma (MM) cells. In this journal, Sun et al. ( Biosci. Rep. 41 , DOI: 10.1042/BSR20203905) identified that WT161 suppresses the cell growth of osteosarcoma cells. This discovery opens the door to future...
View article titled, Targeting the ‘garbage-bin’ to fight cancer: HDAC6 inhibitor WT161 has an anti-tumor effect on <span class="search-highlight">osteosarcoma</span> and synergistically interacts with 5-FU
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Articles

HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

Jun Sun, Wei Wu, Xiaofeng Tang, Feifei Zhang, Cheng Ju, Renfeng Liu, Yiping Liang, Bo Yu, Bin Lv, Yuhong Guo, Duo Zeng, Xuchang Tao, Min Wang, Zhiping Zhang, Changhua Zhang, Xiao-Bin Lv
Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR20203905.
https://doi.org/10.1042/BSR20203905
Published: 30 April 2021
... of cancers. The aim of the present study is to explore the roles of WT161 in osteosarcoma and its underlying mechanisms. Methods: The anti-proliferative effect of WT161 on osteosarcoma cells was examined using MTT assay and colony formation assay. Cell apoptosis was analyzed using flow cytometer...
View article titled, HDAC6 inhibitor WT161 performs anti-tumor effect on <span class="search-highlight">osteosarcoma</span> and synergistically interacts with 5-FU
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Articles

Retraction: MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targetting EIF4G2

Journal: Bioscience Reports
Biosci Rep (2021) 41 (4): BSR-20160542_RET.
https://doi.org/10.1042/BSR-20160542_RET
Published: 16 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation...
View article titled, Retraction: MicroRNA-379 inhibits the proliferation, migration and invasion of human <span class="search-highlight">osteosarcoma</span> cells by targetting EIF4G2
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Articles

Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells

Jonathan J. Sheard, Andrew D. Southam, Hannah L. MacKay, Max A. Ellington, Martyn D. Snow, Farhat L. Khanim, Christopher M. Bunce, William E. Johnson
Journal: Bioscience Reports
Biosci Rep (2021) 41 (1): BSR20202505.
https://doi.org/10.1042/BSR20202505
Published: 05 January 2021
..., medroxyprogesterone acetate and valproic acid on human osteosarcoma cells, i.e., SAOS2 and MG63 compared with their normal cell counterparts, i.e. mesenchymal stem/stromal cells (MSCs). Cell growth, viability and migration were measured by biochemical assay and live cell imaging, whilst levels of lipid-synthesising...
View article titled, Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits <span class="search-highlight">osteosarcoma</span> cell growth without adversely affecting normal mesenchymal stem cells
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Includes: Supplementary data
Articles

Micro-RNA 122 and micro-RNA 96 affected human osteosarcoma biological behavior and associated with prognosis of patients with osteosarcoma

Bin Liu, Shuqiang Yao, Jiping Zhou
Journal: Bioscience Reports
Biosci Rep (2020) 40 (12): BSR20201529.
https://doi.org/10.1042/BSR20201529
Published: 14 December 2020
...Bin Liu; Shuqiang Yao; Jiping Zhou Osteosarcoma (OS) is the most common bone malignancy in both children and adolescents. In the present study, we aimed to explore the association of miRNA-122 and miRNA-96 expression with the clinical characteristics and prognosis of patients with osteosarcoma...
View article titled, Micro-RNA 122 and micro-RNA 96 affected human <span class="search-highlight">osteosarcoma</span> biological behavior and associated with prognosis of patients with <span class="search-highlight">osteosarcoma</span>
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Articles

Retraction: Upregulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration and invasion by inactivating the CTNNB1-mediated Notch signaling pathway

Journal: Bioscience Reports
Biosci Rep (2020) 40 (9): BSR-20171615_RET.
https://doi.org/10.1042/BSR-20171615_RET
Published: 16 September 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . CTNNB1 Invasion MicroRNA-340 Notch signaling pathway Osteosarcoma...
View article titled, Retraction: Upregulation of microRNA-340 promotes <span class="search-highlight">osteosarcoma</span> cell apoptosis while suppressing proliferation, migration and invasion by inactivating the CTNNB1-mediated Notch signaling pathway
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Articles

Expression of concern: MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targeting EIF4G2

Journal: Bioscience Reports
Biosci Rep (2020) 40 (8): BSR-20160542_EOC.
https://doi.org/10.1042/BSR-20160542_EOC
Published: 21 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation...
View article titled, Expression of concern: MicroRNA-379 inhibits the proliferation, migration and invasion of human <span class="search-highlight">osteosarcoma</span> cells by targeting EIF4G2
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Articles

Expression of Concern: von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro

Journal: Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20180372_EOC.
https://doi.org/10.1042/BSR-20180372_EOC
Published: 29 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . migration miR-24 osteosarcoma proliferation von Willebrand factor...
View article titled, Expression of Concern: von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of <span class="search-highlight">osteosarcoma</span> cells in vitro
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Articles

Correction: MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targeting EIF4G2

Journal: Bioscience Reports
Biosci Rep (2020) 40 (7): BSR-20160542_COR.
https://doi.org/10.1042/BSR-20160542_COR
Published: 02 July 2020
... EIF4G2 Invasion MicroRNA-379 Migration Osteosarcoma Proliferation The authors of the original article “MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targeting EIF4G2” ( Bioscience Reports (2017) 37 , DOI: 10.1042/BSR20160542) would...
View article titled, Correction: MicroRNA-379 inhibits the proliferation, migration and invasion of human <span class="search-highlight">osteosarcoma</span> cells by targeting EIF4G2
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Articles

Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis

Li Li, Xiang-an Kong, Mousheng Zang, Jisheng Dong, Yingqi Feng, Binjie Gui, Yong Hu
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20191552.
https://doi.org/10.1042/BSR20191552
Published: 23 June 2020
...Li Li; Xiang-an Kong; Mousheng Zang; Jisheng Dong; Yingqi Feng; Binjie Gui; Yong Hu Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Circular RNAs (circRNAs) are a type of endogenous noncoding RNA that have been verified to participate in cancer pathophysiological...
View article titled, Hsa_circ_0003732 promotes <span class="search-highlight">osteosarcoma</span> cells proliferation via miR-545&#x2F;CCNA2 axis
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Articles

MiR-141-3p overexpression suppresses the malignancy of osteosarcoma by targeting FUS to degrade LDHB

Lei Wang
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20193404.
https://doi.org/10.1042/BSR20193404
Published: 10 June 2020
...Lei Wang Osteosarcoma (OS) is a common malignant bone cancer. Lactate dehydrogenase B (LDHB) has been revealed to act as a tumor promoter in several cancers. It is also revealed to be correlated with poor prognosis in OS, but its molecular mechanism in OS remains veiled. Our work illustrated...
View article titled, MiR-141-3p overexpression suppresses the malignancy of <span class="search-highlight">osteosarcoma</span> by targeting FUS to degrade LDHB
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Includes: Supplementary data
Articles

The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma

Junjie Wang, Jiangdong Ni, Deye Song, Muliang Ding, Jun Huang, Wenzhao Li, Guangxu He
Journal: Bioscience Reports
Biosci Rep (2020) 40 (6): BSR20201232.
https://doi.org/10.1042/BSR20201232
Published: 09 June 2020
...Junjie Wang; Jiangdong Ni; Deye Song; Muliang Ding; Jun Huang; Wenzhao Li; Guangxu He Osteosarcoma is a malignant bone tumour with the lowest survival rates out of all paediatric cancers and is primarily diagnosed in children and adolescents. MNAT1 is a subunit in the cyclin-dependent kinase...
View article titled, The regulatory effect of has-circ-0001146&#x2F;miR-26a-5p&#x2F;MNAT1 network on the proliferation and invasion of <span class="search-highlight">osteosarcoma</span>
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Articles

The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma

Tang Ying, Jin-ling Dong, Cen Yuan, Peng Li, Qingshan Guo
Journal: Bioscience Reports
Biosci Rep (2020) 40 (1): BSR20191251.
https://doi.org/10.1042/BSR20191251
Published: 06 January 2020
...Tang Ying; Jin-ling Dong; Cen Yuan; Peng Li; Qingshan Guo Background: Osteosarcoma is the most common primary bone malignancy in children and adolescents. In order to find factors related to its recurrence, and thus improve recovery prospects, a powerful clinical signature is needed. Long noncoding...
View article titled, The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent <span class="search-highlight">osteosarcoma</span>
Open the PDF for The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent <span class="search-highlight">osteosarcoma</span> in another window
Includes: Supplementary data
Articles

Relationship between red cell distribution width and prognosis of patients with osteosarcoma

Jian Zheng, Xiaopin Yuan, Weichun Guo
Journal: Bioscience Reports
Biosci Rep (2019) 39 (12): BSR20192590.
https://doi.org/10.1042/BSR20192590
Published: 20 December 2019
...Jian Zheng; Xiaopin Yuan; Weichun Guo We retrospectively collected the clinical data and follow-up information of patients with osteosarcoma who were admitted to Department of Orthopedics, RenMin Hospital of Wuhan University from January 2010 to December 2016 and explore the relationship between...
View article titled, Relationship between red cell distribution width and prognosis of patients with <span class="search-highlight">osteosarcoma</span>
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Articles

Overcoming cisplatin resistance in osteosarcoma through the miR-199a -modulated inhibition of HIF-1α

Ajimu Keremu, Abudureyimu Aini, Yusufuaji Maimaitirexiati, Zhilin Liang, Pazila Aila, Paizila Xierela, Aikebaier Tusun, Hanikezi Moming, Aihemaitijiang Yusufu
Journal: Bioscience Reports
Biosci Rep (2019) 39 (11): BSR20170080.
https://doi.org/10.1042/BSR20170080
Published: 15 November 2019
... and prognosis. miR-199a has been shown to be dysregulated in multiple tumour types. However, the association between miR-199a and the chemoresistance features of osteosarcoma are not well understood, the target genes for miR-199a and the regulatory mechanisms are also unknown. In the present study, we...
View article titled, Overcoming cisplatin resistance in <span class="search-highlight">osteosarcoma</span> through the miR-199a -modulated inhibition of HIF-1α
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Articles

Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211

Menglin Cong, Rui Jing
Journal: Bioscience Reports
Biosci Rep (2019) 39 (11): BSR20190291.
https://doi.org/10.1042/BSR20190291
Published: 12 November 2019
...Menglin Cong; Rui Jing Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis. LncRNA tumor suppressor candidate 7 (TUSC-7) was shown to be a tumor suppressor in osteosarcoma. However, the regulation mechanism of TUSC-7 in osteosarcoma is unknown...
View article titled, Long non-coding RNA TUSC7 suppresses <span class="search-highlight">osteosarcoma</span> by targeting miR-211
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Articles

CXCR3 from chemokine receptor family correlates with immune infiltration and predicts poor survival in osteosarcoma

Yin Tang, Zhiqian Gu, Youwei Fu, Junjie Wang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (11): BSR20192134.
https://doi.org/10.1042/BSR20192134
Published: 12 November 2019
...Yin Tang; Zhiqian Gu; Youwei Fu; Junjie Wang Background: Chemokine receptors have a crucial role in regulating tumor mediating immunity and are also implicated in the prognosis of some cancers. Here, the association between CXC chemokine receptors (CXCR2–5) and prognosis in osteosarcoma was studied...
View article titled, CXCR3 from chemokine receptor family correlates with immune infiltration and predicts poor survival in <span class="search-highlight">osteosarcoma</span>
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Includes: Supplementary data
Articles

MicroRNA-93 promotes the tumorigenesis of osteosarcoma by targeting TIMP2

Hua Zhang, Jidong Zhang, Fanrui Meng, Hanzhong Zhu, Hongyu Yan, Yunliang Guo, Shandi Zhang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (8): BSR20191237.
https://doi.org/10.1042/BSR20191237
Published: 23 August 2019
...Hua Zhang; Jidong Zhang; Fanrui Meng; Hanzhong Zhu; Hongyu Yan; Yunliang Guo; Shandi Zhang Osteosarcoma (OS) is the most frequent primary bone malignancy and affects adolescents and young adults. Recently dysregulation of miRNAs has received more attention because of its extensive role in OS...
View article titled, MicroRNA-93 promotes the tumorigenesis of <span class="search-highlight">osteosarcoma</span> by targeting TIMP2
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Articles

LncRNA BE503655 inhibits osteosarcoma cell proliferation, invasion/migration via Wnt/β-catenin pathway

Qiang Huang, Shu-yan Shi, Hai-bo Ji, Shu-xing Xing
Journal: Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20182200.
https://doi.org/10.1042/BSR20182200
Published: 29 July 2019
...Qiang Huang; Shu-yan Shi; Hai-bo Ji; Shu-xing Xing Aim: In previous studies, numerous dysregulated long non-coding RNAs (lncRNAs) were identified by RNA-sequencing (RNA-seq). However, the relationship between lncRNA and osteosarcoma remains unclear. In the present study, the function and mechanism...
View article titled, LncRNA BE503655 inhibits <span class="search-highlight">osteosarcoma</span> cell proliferation, invasion&#x2F;migration via Wnt&#x2F;β-catenin pathway
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Articles

Association between PTEN and clinical-pathological features of osteosarcoma

Jian Zhou, Xia Xiao, Wanchun Wang, Yingquan Luo
Journal: Bioscience Reports
Biosci Rep (2019) 39 (7): BSR20190954.
https://doi.org/10.1042/BSR20190954
Published: 19 July 2019
...Jian Zhou; Xia Xiao; Wanchun Wang; Yingquan Luo Previous studies indicated the prognostic value of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in osteosarcoma (OS). There was a great degree of inconsistency between these reports. The aim of this meta-analysis was to investigate...
View article titled, Association between PTEN and clinical-pathological features of <span class="search-highlight">osteosarcoma</span>
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Includes: Supplementary data
Articles

Silencing microRNA-27a inhibits proliferation and invasion of human osteosarcoma cells through the SFRP1-dependent Wnt/β-catenin signaling pathway

Yu Mu, Lina Zhang, Xue Chen, Si Chen, Yuanyuan Shi, Junfeng Li
Journal: Bioscience Reports
Biosci Rep (2019) 39 (6): BSR20182366.
https://doi.org/10.1042/BSR20182366
Published: 04 June 2019
...Yu Mu; Lina Zhang; Xue Chen; Si Chen; Yuanyuan Shi; Junfeng Li Osteosarcoma is the most common malignant tumor of bone with a high potential for metastasis. Importantly, microRNA-27a (miR-27a) is involved in the progression of osteosarcoma. The present study aims to discuss the effects of miR-27a...
View article titled, Silencing microRNA-27a inhibits proliferation and invasion of human <span class="search-highlight">osteosarcoma</span> cells through the SFRP1-dependent Wnt&#x2F;β-catenin signaling pathway
Open the PDF for Silencing microRNA-27a inhibits proliferation and invasion of human <span class="search-highlight">osteosarcoma</span> cells through the SFRP1-dependent Wnt/β-catenin signaling pathway in another window
Articles

Differential expression and bioinformatics analysis of circRNA in osteosarcoma

Yizhe Xi, Mitra Fowdur, Yun Liu, Hao Wu, Maolin He, Jinmin Zhao
Journal: Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20181514.
https://doi.org/10.1042/BSR20181514
Published: 17 May 2019
...Yizhe Xi; Mitra Fowdur; Yun Liu; Hao Wu; Maolin He; Jinmin Zhao Aim: This research aims to investigate the expression profile of circRNA in osteosarcoma and to identify the underlying pathogenesis core genes of osteosarcoma. Methods : Illumina HiSeq was used to screen differentially expressed...
View article titled, Differential expression and bioinformatics analysis of circRNA in <span class="search-highlight">osteosarcoma</span>
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Includes: Supplementary data
Articles

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma

Weidong He, Ming Lu, Dongbo Xiao
Journal: Bioscience Reports
Biosci Rep (2019) 39 (5): BSR20190612.
https://doi.org/10.1042/BSR20190612
Published: 03 May 2019
...Weidong He; Ming Lu; Dongbo Xiao The dysregulated expression of LSINCT5 (long stress-induced non-coding transcript 5) has been found in various human tumors, and was generally related to cancer progression and unfavorable prognosis. Although the role of LSINCT5 in osteosarcoma was reported not long...
View article titled, LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in <span class="search-highlight">osteosarcoma</span>
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Articles

LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in osteosarcoma

Si Chen, Weiguo Li, Ai Guo
Journal: Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20190447.
https://doi.org/10.1042/BSR20190447
Published: 30 April 2019
...Si Chen; Weiguo Li; Ai Guo lncRNA LOXL1 antisense RNA 1 (lncRNA LOXL1-AS1) was recently found to function as oncogenic lncRNA in glioblastoma, prostate cancer, and medulloblastoma. The role of LOXL1-AS1 in osteosarcoma was still unknown. In our study, we found LOXL1-AS1 expression levels were...
View article titled, LOXL1-AS1 predicts poor prognosis and promotes cell proliferation, migration, and invasion in <span class="search-highlight">osteosarcoma</span>
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Articles

MiR-92a modulates proliferation, apoptosis, migration, and invasion of osteosarcoma cell lines by targeting Dickkopf-related protein 3

Haiyang Yu, Hang Song, Li Liu, Shuo Hu, Yuxin Liao, Gang Li, Xiao Xiao, Xin Chen, Shisheng He
Journal: Bioscience Reports
Biosci Rep (2019) 39 (4): BSR20190410.
https://doi.org/10.1042/BSR20190410
Published: 26 April 2019
...Haiyang Yu; Hang Song; Li Liu; Shuo Hu; Yuxin Liao; Gang Li; Xiao Xiao; Xin Chen; Shisheng He Osteosarcoma (OS) is recognized as a common malignant tumor with a high trend of metastasis and diffusion. Despite the progresses that have been made in surgery, chemotherapy, and radiotherapy...
View article titled, MiR-92a modulates proliferation, apoptosis, migration, and invasion of <span class="search-highlight">osteosarcoma</span> cell lines by targeting Dickkopf-related protein 3
Open the PDF for MiR-92a modulates proliferation, apoptosis, migration, and invasion of <span class="search-highlight">osteosarcoma</span> cell lines by targeting Dickkopf-related protein 3 in another window
Includes: Supplementary data
Articles

The proliferation and invasion of osteosarcoma are inhibited by miR-101 via targetting ZEB2

Haopeng Lin, Xiaodong Zheng, Ting Lu, Yang Gu, Canhao Zheng, Huajie Yan
Journal: Bioscience Reports
Biosci Rep (2019) 39 (2): BSR20181283.
https://doi.org/10.1042/BSR20181283
Published: 08 February 2019
...Haopeng Lin; Xiaodong Zheng; Ting Lu; Yang Gu; Canhao Zheng; Huajie Yan Having a better grasp of the molecular mechanisms underlying carcinogenesis and progression in osteosarcoma would be helpful to find novel therapeutic targets. Different types of cancers have presented abnormal expression...
View article titled, The proliferation and invasion of <span class="search-highlight">osteosarcoma</span> are inhibited by miR-101 via targetting ZEB2
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Articles

The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells

Dawei Yang, Hao Zhang, Jianjun Wu, Ruishuang Ma, Zongyu Li, Kunzheng Wang, Fan Yang
Journal: Bioscience Reports
Biosci Rep (2019) 39 (1): BSR20181707.
https://doi.org/10.1042/BSR20181707
Published: 15 January 2019
...Dawei Yang; Hao Zhang; Jianjun Wu; Ruishuang Ma; Zongyu Li; Kunzheng Wang; Fan Yang Background: Osteosarcoma (OS) is the most common malignant neoplasm in children and adolescents with a very high propensity for local invasion and poor response to current therapy. Anti-cancer effect...
View article titled, The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells
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Articles

Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway

Bin Liu, Liang Xu, E-Nuo Dai, Jia-Xin Tian, Jian-Min Li
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181501.
https://doi.org/10.1042/BSR20181501
Published: 14 December 2018
...Bin Liu; Liang Xu; E-Nuo Dai; Jia-Xin Tian; Jian-Min Li Osteosarcoma (OS) is the most common primary malignancy of skeleton with higher mortality rates amongst children and young adults worldwide, whereas effective and secure therapies have also been sought by researches with ongoing efforts...
View article titled, Anti-tumoral potential of MDA19 in human <span class="search-highlight">osteosarcoma</span> via suppressing PI3K&#x2F;Akt&#x2F;mTOR signaling pathway
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Articles

Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human osteosarcoma cells

Xiong Wang, Lei Zhang, Wenji Wang, Yuchen Wang, Ye Chen, Ruimin Xie, Xiang Li, Yongping Wang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181384.
https://doi.org/10.1042/BSR20181384
Published: 21 November 2018
...Xiong Wang; Lei Zhang; Wenji Wang; Yuchen Wang; Ye Chen; Ruimin Xie; Xiang Li; Yongping Wang Human osteosarcoma is the most frequent primary malignant of bone, and often occurs in adolescents. However, molecular mechanism of this disease remains unclear. In the present study, we found...
View article titled, Rhotekin 2 silencing inhibits proliferation and induces apoptosis in human <span class="search-highlight">osteosarcoma</span> cells
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Articles

von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of osteosarcoma cells in vitro

Ling Liu, Jun Pan, Huan Wang, Zhenni Ma, Jie Yin, Feng Yuan, Quanwen Yuan, Lu Zhou, Xiaofeng Liu, Yu Zhang, Zhaohua Bao, Huilin Yang, Jing Ling
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20180372.
https://doi.org/10.1042/BSR20180372
Published: 16 November 2018
...Ling Liu; Jun Pan; Huan Wang; Zhenni Ma; Jie Yin; Feng Yuan; Quanwen Yuan; Lu Zhou; Xiaofeng Liu; Yu Zhang; Zhaohua Bao; Huilin Yang; Jing Ling von Willebrand factor (vWF) is a major procoagulant molecule that was shown to differentiate between metastatic and primary osteosarcoma (OS) tissues...
View article titled, von Willebrand factor rescued by miR-24 inhibition facilitates the proliferation and migration of <span class="search-highlight">osteosarcoma</span> cells in vitro
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Articles

LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma

Qiang Huang, Jiao Yang, Xin He, Shuyan Shi, Shuxing Xing
Journal: Bioscience Reports
Biosci Rep (2018) 38 (6): BSR20181498.
https://doi.org/10.1042/BSR20181498
Published: 16 November 2018
... unknown in osteosarcoma (OS). In our study, BDNF-AS expression was found to be decreased in OS tissues and cells. Moreover, BDNF-AS low expression was correlated with advanced Enneking stage, large tumor size and poor prognosis in OS patients. The multivariate analysis suggested low expression of BDNF...
View article titled, LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in <span class="search-highlight">osteosarcoma</span>
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Articles

GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma

Shian Liao, Sijia Zhou, Chao Wang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (5): BSR20181171.
https://doi.org/10.1042/BSR20181171
Published: 10 October 2018
... function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated...
View article titled, GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in <span class="search-highlight">osteosarcoma</span>
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Articles

Up-regulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway

Bao-Long Pan, Ling Wu, Li Pan, Yu-Xi Yang, Hu-Huan Li, Yan-Juan Dai, Zi-Qian He, Ling Tan, You-Guang Huang, Zong-Wu Tong, Jun-Long Liao
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20171615.
https://doi.org/10.1042/BSR20171615
Published: 31 August 2018
...Bao-Long Pan; Ling Wu; Li Pan; Yu-Xi Yang; Hu-Huan Li; Yan-Juan Dai; Zi-Qian He; Ling Tan; You-Guang Huang; Zong-Wu Tong; Jun-Long Liao Osteosarcoma (OS) is the most common histological form of primary bone cancer. It is most prevalent in teenagers and young adults. The present study aims...
View article titled, Up-regulation of microRNA-340 promotes <span class="search-highlight">osteosarcoma</span> cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway
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Articles

Adenovirus-mediated small interfering RNA targeting ezrin induces apoptosis and inhibits metastasis of human osteosarcoma MG-63 cells

Zhi-Wei Tao, Ping-An Zou
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20180351.
https://doi.org/10.1042/BSR20180351
Published: 29 August 2018
...Zhi-Wei Tao; Ping-An Zou Osteosarcoma is a disease prone to recurrence and metastasis, and adenovirus expression vector is frequently studied as a therapeutic target of osteosarcoma in recent years. The present study attempts to explore the effect of adenovirus-mediated siRNA targetting ezrin...
View article titled, Adenovirus-mediated small interfering RNA targeting ezrin induces apoptosis and inhibits metastasis of human <span class="search-highlight">osteosarcoma</span> MG-63 cells
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Articles

miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma

Shuai Lv, Meng Guan
Journal: Bioscience Reports
Biosci Rep (2018) 38 (4): BSR20171675.
https://doi.org/10.1042/BSR20171675
Published: 13 July 2018
...Shuai Lv; Meng Guan Previous literatures have reported the role of human micro RNA-1284 (hsa-miR-1284, in short miR-1284) in diverse cancers. However, its biological function in osteosarcoma pathogenesis remains unknown. In the present study, we investigated the potential role of miR-1284...
View article titled, miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in <span class="search-highlight">osteosarcoma</span>
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Articles

miR-34 inhibits growth and promotes apoptosis of osteosarcoma in nude mice through targetly regulating TGIF2 expression

Liang Xi, Yongfeng Zhang, Shengnan Kong, Wei Liang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (3): BSR20180078.
https://doi.org/10.1042/BSR20180078
Published: 12 June 2018
...Liang Xi; Yongfeng Zhang; Shengnan Kong; Wei Liang miR-34 was reported to be involved in multiple tumors occurrence and development. The aim of the present study was to explore the impact of miR-34 on osteosarcoma and related mechanisms. Tumor tissues and non-tumor tissues of 34 patients...
View article titled, miR-34 inhibits growth and promotes apoptosis of <span class="search-highlight">osteosarcoma</span> in nude mice through targetly regulating TGIF2 expression
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Articles

Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma

Yuliang Hu, Qiuyong Yang, Long Wang, Shuo Wang, Fei Sun, Dong Xu, Jian Jiang
Journal: Bioscience Reports
Biosci Rep (2018) 38 (3): BSR20180375.
https://doi.org/10.1042/BSR20180375
Published: 31 May 2018
... to be an oncogene to promote tumor growth and metastasis of many cancers. However, the clinical significance and function of NEAT1 in osteosarcoma (OS) remain to be discovered. We here collected OS tissues ( n =40) and adjacent non-tumor tissues ( n =20) to determine the expression of NEAT1 and its clinical...
View article titled, Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in <span class="search-highlight">osteosarcoma</span>
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Articles

miR-422a inhibits osteosarcoma proliferation by targeting BCL2L2 and KRAS

Hao Zhang, Qian-Yun He, Guang-Chao Wang, Da-Ke Tong, Ren-Kai Wang, Wen-Bin Ding, Cheng Li, Qiang Wei, Chen Ding, Pei-Zhao Liu, Hao-Chen Cui, Xin Zhang, Di Li, Hao Tang, Fang Ji
Journal: Bioscience Reports
Biosci Rep (2018) 38 (2): BSR20170339.
https://doi.org/10.1042/BSR20170339
Published: 21 March 2018
...Hao Zhang; Qian-Yun He; Guang-Chao Wang; Da-Ke Tong; Ren-Kai Wang; Wen-Bin Ding; Cheng Li; Qiang Wei; Chen Ding; Pei-Zhao Liu; Hao-Chen Cui; Xin Zhang; Di Li; Hao Tang; Fang Ji Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. However, the underlying...
View article titled, miR-422a inhibits <span class="search-highlight">osteosarcoma</span> proliferation by targeting BCL2L2 and KRAS
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Includes: Supplementary data
Articles

MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targetting EIF4G2

Xi Xie, Yu-Sheng Li, Wen-Feng Xiao, Zhen-Han Deng, Hong-Bo He, Qing Liu, Wei Luo
Journal: Bioscience Reports
Biosci Rep (2017) 37 (3): BSR20160542.
https://doi.org/10.1042/BSR20160542
Published: 17 May 2017
...Xi Xie; Yu-Sheng Li; Wen-Feng Xiao; Zhen-Han Deng; Hong-Bo He; Qing Liu; Wei Luo Osteosarcoma (OS) is an aggressive malignant mesenchymal neoplasm amongst adolescents. The aim of the present study was to explore the various modes of action that miR-379 has on the proliferation, migration...
View article titled, MicroRNA-379 inhibits the proliferation, migration and invasion of human <span class="search-highlight">osteosarcoma</span> cells by targetting EIF4G2
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Articles

Cucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signalling pathway

Ying Wang, Shumei Xu, Yaochi Wu, Junfeng Zhang
Journal: Bioscience Reports
Biosci Rep (2016) 36 (6): e00405.
https://doi.org/10.1042/BSR20160165
Published: 08 November 2016
... on osteosarcoma (OS) have not been well understood. The present study aimed to test whether CuE could inhibit growth and invasion of OS cells and reveal its underlying molecular mechanism. After various concentrations of CuE treatment, the anti-proliferative effect of CuE was assessed using the cell counting Kit...
View article titled, Cucurbitacin E inhibits <span class="search-highlight">osteosarcoma</span> cells proliferation and invasion through attenuation of PI3K&#x2F;AKT&#x2F;mTOR signalling pathway
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Includes: Supplementary data