... Figure 6 Repsox represses translocation of Smad3 and Smad4 into nucleus resulting in attenuation of the effect of TGF-β1 on Cx43 ( D ) Representative IF staining by CLSM showing reduced translocation of Smad4 in osteocytes after pretreatment with 50 μM Repsox for 6 h and then treatment...

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Connexin 43 Gap junction Osteocyte Smad3 Smad4 TGF-β1 The Editorial...

...Katherine A. Staines; Mark Hopkinson; Scott Dillon; Louise A. Stephen; Robert Fleming; Antonia Sophocleous; David J. Buttle; Andrew A. Pitsillides; Colin Farquharson E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network...

... on the expression of Cx43 in different cell types. To date, the effect of TGF-β1 on the Cx43 expression of osteocytes is still unknown. In the present study, we detected the expression of TGF-β1 in osteocytes and bone tissue, and then used recombinant mouse TGF-β1 to elucidate its effect on gap junctions (GJs...