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Keywords: Osteoarthritis
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Biosci Rep (2024) 44 (5): BSR20232102.
Published: 10 May 2024
...Amani Y. Owaidah Osteoarthritis (OA) is a long-term, persistent joint disorder characterized by bone and cartilage degradation, resulting in tightness, pain, and restricted movement. Current attempts in cartilage regeneration are cell-based therapies using stem cells. Multipotent stem cells...
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Biosci Rep (2024) 44 (1): BSR20231730.
Published: 12 January 2024
...Jing Song; Xuemin Zeng; Chenzhi Li; Hongyan Yin; Sui Mao; Dapeng Ren Osteoarthritis (OA) is characterized by cartilage degeneration and destruction, leading to joint ankylosis and disability. The major challenge in diagnosing OA at early stage is not only lack of clinical symptoms but also...
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Biosci Rep (2022) 42 (6): BSR-2017-1691_RET.
Published: 30 May 2022
... Attribution License 4.0 (CC BY) . autophagy curcumin Osteoarthritis This article is being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader alerting the Editorial Board to several duplications...
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Biosci Rep (2020) 40 (11): BSR20200926.
Published: 13 November 2020
...Senbo An; Jingyi Li; Wenqing Xie; Ni Yin; Yusheng Li; Yihe Hu Osteoarthritis (OA), the most common degenerative joint disease, is characterized by the cardinal symptoms of chronic pain and restricted joint activity. The complicated pathological changes associated with OA and unclear mechanistic...
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Biosci Rep (2020) 40 (11): BSR20201601.
Published: 03 November 2020
...Qingpu Zhang; Xiaomiao Qiao; Wenwei Xia The dysregulated circular RNAs (circRNAs) are relevant to the development of osteoarthritis (OA). The circRNA serpin family E member 2 (circSERPINE2) is dysregulated in OA, while the role and mechanism of circSERPINE2 in OA are largely unknown. The aim of our...
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Biosci Rep (2020) 40 (6): BSR20191908.
Published: 22 June 2020
...Yinwei Bai; Kun Chen; Jianfeng Zhan; Mingxin Wu Background/Aims: MicroRNAs (miRNAs) are involved in the pathogenesis of osteoarthritis (OA). The present study aimed to investigate the potential function of miR-122 in the development of OA and its potential molecular mechanisms. Methods...
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Biosci Rep (2020) 40 (5): BSR20200417.
Published: 28 May 2020
...Yu Zhao; Ding Ma; Bingchen Dong; Ming Li This research aimed to explore the role of period circadian clock 2 (Per2) in the evolution of osteoarthritis (OA) and the relevant mechanisms. Per2 messenger RNA (mRNA) and protein levels were markedly reduced in NHAC-kn cells treated with 5 µg/ml...
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Biosci Rep (2019) 39 (7): BSR20191374.
Published: 19 July 2019
...Min Tu; Yao Yao; Feng Hua Qiao; Li Wang Osteoarthritis (OA) is the most common form of arthritis, and connective tissue growth factor (CTGF) is found to be up-regulated in adjacent areas of cartilage surface damage. CTGF is present in osteophytes of late stage OA. In the present study, we have...
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Biosci Rep (2019) 39 (2): BSR20181473.
Published: 15 February 2019
...Li Tan; Raghunatha R. Yammani Obesity, a major risk factor for the development of osteoarthritis (OA), is associated with increased circulating levels of free fatty acids (FFA). However, the role of these FFAs in OA pathophysiology is not clearly understood. In the present study, we found...
Includes: Supplementary data
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Biosci Rep (2019) 39 (1): BSR20182228.
Published: 25 January 2019
...Wenpeng Hui; Zhong Cao; Xiao Wang; Junfeng Zhu Several studies have explored the association between matrix Gla protein (MGP) gene polymorphism and knee osteoarthritis (OA) risk; however, they obtained conflicting findings. The present study aims to explore the association of MGP gene polymorphism...
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Biosci Rep (2018) 38 (6): BSR20181619.
Published: 30 November 2018
... BY) . ADAMTS4 ADAMTS5 lumbar disc degeneration meta analysis osteoarthritis single nucleotide polymorphisms Musculoskeletal degenerative diseases are a diverse group of pathological conditions affecting bone, cartilage, joint and other connective tissues. They are typically characterized by severe...
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Biosci Rep (2018) 38 (5): BSR20180542.
Published: 31 October 2018
...Hui-Zi Li; Zhong Lin; Xiang-He Xu; Nan Lin; Hua-Ding Lu Osteoarthritis (OA), a common joint disease in elderly, causes serious social and economic burdens worldwide. Previous studies indicated that some differentially expressed circular RNAs (circRNAs) participated in the initiation and progression...
Includes: Supplementary data
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Biosci Rep (2018) 38 (4): BSR20171691.
Published: 03 July 2018
...Guowang Zhang; Jiaqing Cao; Erzhu Yang; Bo Liang; Jianing Ding; Jiaming Liang; Jianguang Xu Reduced autophagy has been implied in chondrocyte death and osteoarthritis. Curcumin (Cur) owns therapeutic effect against osteoarthritis (OA) and enhances autophagy in various tumor cells. Whether...
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Biosci Rep (2018) 38 (3): BSR20180380.
Published: 15 May 2018
...Hao-Yu Yang; Wen-Hao Hu; Tao Jiang; Hui Zhao A growing body of evidence suggested that smad family member 3 gene rs12901499 polymorphism was associated with the risk of osteoarthritis. However, the results of previous studies were conflicting. In the present study, we assessed whether smad family...
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Biosci Rep (2017) 37 (2): BSR20160588.
Published: 28 April 2017
...Jiye He; Jiahong Zhang; Dongliang Wang Osteoarthritis (OA) is the most common type of joint disease, leading to a major cause of pain and disability. OA is characterized by the continuous degradation of articular cartilage, mainly resulting in an imbalance between synthesis and degradation...
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Biosci Rep (2016) 36 (3): e00332.
Published: 06 May 2016
...Meng Wei; Qingyun Xie; Jun Zhu; Tao Wang; Fan Zhang; Yue Cheng; Dongyang Guo; Ying Wang; Liweng Mo; Shuai Wang CCL2-mediated macrophage infiltration in articular tissues plays a pivotal role in the development of the osteoarthritis (OA). miRNAs regulate the onset and progression of diseases via...
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Biosci Rep (2015) 35 (3): e00204.
Published: 11 June 2015
...Qingyun Xie; Meng Wei; Xia Kang; Da Liu; Yi Quan; Xianming Pan; Xiling Liu; Dongfa Liao; Jinbiao Liu; Bo Zhang Obesity is causally linked to osteoarthritis (OA), with the mechanism being not fully elucidated. miRNAs (miRs) are pivotal regulators of various diseases in multiple tissues, including...