... under the Creative Commons Attribution License 4.0 (CC BY) . endoplasmic reticulum endosomes intracellular transport Lysosomes neurodegeneration neuronal ceroid lipofuscinosis Newly synthesized proteins containing the 20–25 amino acid signal peptide undergo their first modifications...

... neurodegeneration Parkinson’s disease Parkinson’s disease (PD) is a common, progressive and multi-system neurodegenerative disorder, for which there is currently no disease modifying therapeutic. Affecting 2% of the population over 65 [ 1 ], PD is clinically characterised by the development...

... 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alzheimer's disease disease models neurodegeneration tau protein...

.... Such understanding may have further implications in neurodegeneration and peripheral neuropathy. Expression and purification of maltose-binding protein (MBP)-TRPV2-Ct (C-terminal cytoplasmic domain of TRPV2 fused with MBP) and as MBP-LacZ (LacZ fused with MBP) was based on a protocol described previously [ 20...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cystamine cysteamine celiac disease cardiac disease neurodegeneration tranglutaminase Cystamine is a symmetric organodisulphide commonly used as an inhibitor of transglutaminases. This disulphide is also reduced...

... of phosphatidylinositol 3,5-bisphosphate [PI(3,5) P 2 ]. PIKfyve function is required for homoeostasis of the endo/lysosomal system and is crucially implicated in neuronal function and integrity, as loss of function mutations in the PIKfyve complex lead to neurodegeneration in mouse models and human patients. Our recent...

... and Alzheimer's disease involve lysosome dysfunction and may similarly suffer from vitamin B 12 trapping. lysosome mitochondria neurodegeneration subcellular-fractionation vitamin B 12 Vitamin B 12 [Cbl (cobalamin)] is required for erythrocyte formation and DNA synthesis, and plays a critical...

..., distribution and reproduction in any medium, provided the original work is properly cited. cognition diabetes energy homoeostasis ghrelin hormone insulin leptin neural circuitry neurodegeneration Besides the hypothalamus, LepRb is present in several brain regions related to cognition [ 42...

... in mitochondria in various tissues of patients with neurodegenerative disorders, the question “is mitochondrial dysfunction a necessary step in neurodegeneration?” is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic...

.... Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene–environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human...

... involved in both neurodegeneration and cancer. An impairment of Wnt signals appears to be associated with aspects of neurodegenerative pathologies while overactivation of Wnt signaling is a common theme in several types of human tumors. Therefore, although therapeutic approaches aimed at modulating Wnt...

...+ . These results suggest that Aβ 25–35 can promote the PTP induced by Ca 2+ . © 2001 Plenum Publishing Corporation 2001 Amyloid β-peptide permeability transition pore brain mitochondria mitochondrial transmembrane potential calcium fluxes neurodegeneration Bioscience Reports, Vol. 21, No. 6...