... License 4.0 (CC BY) . Colitis-associated cancer Colorectal cancer Interleukin-6 Lipocalin 2 NF-kB STAT3 Inflammatory bowel diseases (IBDs) can be divided into two major disorders: ulcerative colitis and Crohn’s disease [ 1 ]. Although colitis-associated colorectal cancer (CAC) accounts...

... BY) . hypoxic HUVECs IL-1β miR-24-3p NF-kB NKAP Acute myocardial infarction (AMI) and heart failure (HF) are often the leading causes of death and disability worldwide, especially in developed countries [ 1–3 ]. AMI is an event of myocardial necrosis that may lead to functional loss in the diastolic...

... demonstrated the synergistic effects of orlistat combined with enzalutamide in vitro and castration in viv o on human PCa. castration therapy enzalutamide fatty acid synthase NF-kB orlistat prostate cancer Prostate cancer (PCa) is the second most frequent cancer and the fifth leading cause...

..., glypican 3 (GPC3), nuclear factor κ-light-chain-enhancer of activated B cells (NF-kB), epidermal growth factor receptor, ERK1/2, tumor necrosis factor-α (TNF-α), regenerating islet-derived 1 and 3 α (REG1A and 3A), substance P (SP)/neurokinin-1 receptor and PARP-1. The present review describes the key role...

... the Creative Commons Attribution License 4.0 (CC BY) . cancer inflammasome NLR NOD1 NOD2 NF-kB The innate immune system is our first line of defense against infections from an enormous diversity of microbes and viruses. The human innate immunity relies on a wide range of receptors...

..., NF-kB, and p38 signaling pathway were determined, and found that overexpression of PAK1 activated NF-kB and p38. Inhibition of PAK1 by shRNA or small molecule inhibitor FRAX597 decreased NF-kB and p38 activity, and alleviated the pathological damage in the pancreas, including decreasing the amylase...