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Articles

Polypharmacology of ambroxol in the treatment of COVID-19

Ziyuan Wang, Minghui Yang, Xi Chen, Rongxin Xiao, Yu Dong, Ming Chu, Guojie Song, Yuedan Wang

Biosci Rep (2023) 43 (2): BSR20221927.

DOI: https://doi.org/10.1042/BSR20221927

Published: 27 February 2023

... and in silico screening revealed that ambroxol may impede cell entry of SARS-CoV-2 by binding to neuropilin-1. Ambroxol could also interact with multiple inflammatory factors and signaling pathways, especially nuclear factor kappa B (NF-κB), to interfere cytokines cascade activated by SARS-CoV-2 internalization...

View article titled, Polypharmacology of ambroxol in the treatment of COVID-19

Includes: Supplementary data

Articles

Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Biosci Rep (2022) 42 (12): BSR-2017-1294_RET.

DOI: https://doi.org/10.1042/BSR-2017-1294_RET

Published: 22 December 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . diabetic impaired wound healing inflammation NF-κB Vitamin D...

View article titled, Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Articles

Retraction: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-kB pathway

Biosci Rep (2022) 42 (7): BSR-2019-1611_RET.

DOI: https://doi.org/10.1042/BSR-2019-1611_RET

Published: 27 July 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AKT3 breast cancer metastasis miRNA NF-κB This article is being...

View article titled, Retraction: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-kB pathway

Articles

TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis

Hong Lu, Li Ai, Baoyue Zhang

Biosci Rep (2022) 42 (3): BSR20212224.

DOI: https://doi.org/10.1042/BSR20212224

Published: 17 March 2022

... assays. The activation of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway was detected by Western blot. Further, dual-luciferase reporting system and chromatin immunoprecipitation (ChIP) were used to detect the transcriptional regulation of AQP4 by p65. These experiments...

View article titled, TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis

Includes: Supplementary data

Articles

Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice

Yibin Zeng, Hongying Zhao, Tong Zhang, Chao Zhang, Yanni He, Lingbo Du, Fuguo Zuo, Wuqing Wang

Biosci Rep (2022) 42 (1): BSR20212196.

DOI: https://doi.org/10.1042/BSR20212196

Published: 24 January 2022

... in the acute toxicity study of Pun. Conclusion: Pun improves LPS-induced ALI mainly through its anti-inflammatory properties, which is associated with nuclear factor-κB (NF-κB) and MAPKs signaling pathways. The study implied that Pun maybe a potent agent against ALI in future clinic. Acute lung injury...

View article titled, Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice

Includes: Supplementary data

Articles

Expression of Concern: miR-15b Reduces Amyloid-β Accumulation in SH-SY5Y Cell Line through Targeting NF-κB signaling and BACE1

Biosci Rep (2021) 41 (4): BSR-20180051_EOC.

DOI: https://doi.org/10.1042/BSR-20180051_EOC

Published: 09 April 2021

... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Aβ Alzheimer's disease BACE1 miR-15b NF-κB The Editorial Office has...

View article titled, Expression of Concern: miR-15b Reduces Amyloid-β Accumulation in SH-SY5Y Cell Line through Targeting NF-κB signaling and BACE1

Articles

The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma

Jin Liu, Mingyi Zhu, Yun Feng, Qianli Tang, Meng Xu

Biosci Rep (2020) 40 (5): BSR20190239.

DOI: https://doi.org/10.1042/BSR20190239

Published: 27 May 2020

...Jin Liu; Mingyi Zhu; Yun Feng; Qianli Tang; Meng Xu Aim : To investigate the relationship between PI3K/Akt/NF-κB cellular signal pathway and the expression of P-gp and LRP in multidrug resistance (MDR) cell of nasopharyngeal carcinoma. Method : The PI3K, p-Akt and NF-κB/p65 as the activity of PI3K...

View article titled, The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma

Articles

Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling

Guiming Liu, Jing Xie, Yurui Shi, Rongda Chen, Li Li, Mengxue Wang, Meizhu Zheng, Jiaming Xu

Biosci Rep (2020) 40 (2): BSR20194230.

DOI: https://doi.org/10.1042/BSR20194230

Published: 14 February 2020

... and TNF-α in Raw264.7 murine macrophages stimulated by LPS. Real-time PCR assay demonstrated the SOG dose-dependently inhibited transcription of these cytokines as well. In addition, it was also found that NF-κB activation and MAPKs phosphorylation including p38, JNK and ERK1/2 induced by LPS were...

View article titled, Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling

Articles

Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model

Xiaolei Hu, Hengyan Zhang, Yuan Song, Langen Zhuang, Qingqing Yang, Minglin Pan, Fengling Chen

Biosci Rep (2020) 40 (1): BSR20191672.

DOI: https://doi.org/10.1042/BSR20191672

Published: 02 January 2020

...-1β) and Ufm1 expression were highly increased both in the peritoneal macrophages of db/db mice and Raw264.7 cells induced by lipopolysaccharide (LPS). Western blot and luciferase reporter assay showed that NF-κB pathway was obviously activated in macrophages and the expression of LZAP, an inhibitor...

View article titled, Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model

Articles

Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5/NF-κB pathway

Rui Zhang, Xiao Han, Tao Huang, Xiuge Wang

Biosci Rep (2019) 39 (10): BSR20181740.

DOI: https://doi.org/10.1042/BSR20181740

Published: 18 October 2019

... the expression IKK and the activity of nuclear transcription factor-κB (NF-κB) via GAS5, and proved that long non-coding RNA (lncRNA) GAS5 was positively related with IKK. And we proved GAS5 regulated the expression of IKK and the activity of NF-κB. In addition, DGT inhibited the viability of MES-13 cells...

View article titled, Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5/NF-κB pathway

Articles

Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway

Jianqing Pan, Xiang Li, Fei Guo, Zhigang Yang, Lingling Zhang, Chunshui Yang

Biosci Rep (2019) 39 (9): BSR20191452.

DOI: https://doi.org/10.1042/BSR20191452

Published: 06 September 2019

.... In the present study, we aimed to elucidate the anti-autophagy and anti-apoptosis effects of ginkgetin via nuclear factor κB (NF-κB)/p53 pathway in cerebral I/R rats. Methods : Rats were administrated 2-h occlusion of right middle cerebral artery before the 24-h reperfusion followed. There were three doses...

View article titled, Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway

Articles

LncRNA SNHG1 alleviates IL-1β-induced osteoarthritis by inhibiting miR-16-5p-mediated p38 MAPK and NF-κB signaling pathways

Jinlai Lei, Yahui Fu, Yan Zhuang, Kun Zhang, Daigang Lu

Biosci Rep (2019) 39 (9): BSR20191523.

DOI: https://doi.org/10.1042/BSR20191523

Published: 06 September 2019

... overexpression reversed SNHG1-inhibited aberrant catabolism and inflammation triggered by IL-1β stimulation. Finally, SNHG1 inhibits the expression of miR-16-5p-mediated factors involved in p38MAPK and NF-κB signaling pathways, including ERK1/2, p-p38 and p-p65. Taken together, the results of our studies...

View article titled, LncRNA SNHG1 alleviates IL-1β-induced osteoarthritis by inhibiting miR-16-5p-mediated p38 MAPK and NF-κB signaling pathways

Articles

FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

Nanwen Zhang, Zhiwei Liu, Hongbin Luo, Weifang Wu, Kaimei Nie, Lin Cai, Shuangyu Tan, Xiaole Chen, Ying Huang, Jiaxing Liu, Meina Lv, Xin Zhang, Yun Fan, Yuying Lin, Shennan Ye, Yang Liu, Lixian Wu, Jianhua Xu

Biosci Rep (2019) 39 (9): BSR20182263.

DOI: https://doi.org/10.1042/BSR20182263

Published: 03 September 2019

.... The hind paw volume and arthritis index (AI) were measured, and radiographic and histological examinations were performed. Twenty-one days later, the animals were killed and left ankle joints were removed to measure protein expression of the elements of the nuclear factor κB (NF-κB) and mitogen-activated...

View article titled, FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

Articles

C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

Weiping Sun, Yongquan Wu, Mingyang Gao, Ying Tian, Peng Qi, Yujing Shen, Lihong Huang, Liang Shi, Yanjiang Wang, Xingpeng Liu

Biosci Rep (2019) 39 (8): BSR20190888.

DOI: https://doi.org/10.1042/BSR20190888

Published: 28 August 2019

... fibrosis, through TLR4/NF-κB/TGF-β pathway. HL-1 cells were treated with either 25 or 50 μg/ml recombinant human CRP. TGF-β1 and NF-κB inhibitors were given either solely or together to the 50 μg/ml CRP-treated cells. Cell proliferation, apoptosis, the expression of apoptotic factors and TLR4, IL-6, TGF-β1...

View article titled, C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

Articles

MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

Liwei Ruan, Xiaojun Qian

Biosci Rep (2019) 39 (8): BSR20191611.

DOI: https://doi.org/10.1042/BSR20191611

Published: 23 August 2019

...-5p. Furthermore, decreased miR-16-5p in cell and animal models enhanced migration and proliferation of breast cancer cells, stimulated cell cycle and reduced cell apoptosis. Finally, we found miR-16-5p restrained the NF-κB pathway and decreased AKT3 gene, thereby suppressing the breast cancer...

View article titled, MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

Includes: Supplementary data

Articles

Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status

Lin Zhou, Jinhua Zhou, Bin Sheng, Xin Li, Youchao Yuan

Biosci Rep (2019) 39 (8): BSR20190419.

DOI: https://doi.org/10.1042/BSR20190419

Published: 23 August 2019

... prevented H 2 O 2 -induced death and degeneration of chondrocytes partly by enhancing antioxidant capacity. Mechanistically, Dex attenuated H 2 O 2 -mediated activation of NF-κB and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3), both of which play key roles in inflammation and inflammatory damage...

View article titled, Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status

Articles

PLCE1 promotes myocardial ischemia–reperfusion injury in H/R H9c2 cells and I/R rats by promoting inflammation

WenHua Li, Yong Li, Ying Chu, WeiMin Wu, QiuHua Yu, XiaoBo Zhu, Qiang Wang

Biosci Rep (2019) 39 (7): BSR20181613.

DOI: https://doi.org/10.1042/BSR20181613

Published: 05 July 2019

..., overexpression of PLCE1 increased the phosphorylation of p38, ERK1/2, and nuclear factor-κ B (NF-κB) P65 while knockdown of PLCE1 inhibited their phosphorylation. In conclusion, the present study provided evidence that PLCE1 was up-regulated in H/R H9c2 cell and I/R rat. Overexpression of PLCE1 promoted...

View article titled, PLCE1 promotes myocardial ischemia–reperfusion injury in H/R H9c2 cells and I/R rats by promoting inflammation

Articles

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling

Cunrong Chen, Jingjing Wang, Jianfei Chen, Lili Zhou, Hui Wang, Junnian Chen, Zhihui Xu, Shuaijun Zhu, Wei Liu, Ranjie Yu, Junli Lu, Haoteng Luo, Min Chen, Weiwen Chen

Biosci Rep (2019) 39 (6): BSR20190190.

DOI: https://doi.org/10.1042/BSR20190190

Published: 20 June 2019

...-inflammatory IL-10 in mice lung tissue. Furthermore, morusin treatment inhibited the activation of Wnt/β-catenin and NF-κB pathways in mice lung tissue. Taken together, our results suggest that morusin relieves mycoplasma pneumonia via the inhibition of the activation of Wnt/β-catenin and NF-κB pathways...

View article titled, Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling

Articles

Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signaling

Mouli Tian, Mei Yang, Zhenjie Li, Yiru Wang, Wei Chen, Liye Yang, Yonghua Li, Hongbin Yuan

Biosci Rep (2019) 39 (4): BSR20181584.

DOI: https://doi.org/10.1042/BSR20181584

Published: 26 April 2019

... to assess the expression of IκB-α protein. Western blotting was applied to analyze NF-κB-signaling related proteins and Cell Counting Kit-8 (CCK-8) was used for assessing cell viability. Molecular docking and drug affinity responsive target stability (DARTS) assay were used for the detection...

View article titled, Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signaling

Articles

Abnormally expressed miR-23b in Chinese Mongolian at high cardiovascular risk may contribute to monocyte/macrophage inflammatory reaction in atherosclerosis

Li-ping He, Xing-sheng Zhao, Le-ping He

Biosci Rep (2018) 38 (6): BSR20180673.

DOI: https://doi.org/10.1042/BSR20180673

Published: 16 November 2018

... macrophage. MiR-23b regulated nuclear factor-κB (NF-κB) pathway through targeting A20. MiR-23b mediated oxLDL-induced inflammatory response of peripheral blood mononuclear cell in the Mongolian at high cardiovascular risk. Conclusion MiR-23b enhanced oxLDL-induced inflammatory response of macrophages...

View article titled, Abnormally expressed miR-23b in Chinese Mongolian at high cardiovascular risk may contribute to monocyte/macrophage inflammatory reaction in atherosclerosis

Articles

miR-15b reduces amyloid-β accumulation in SH-SY5Y cell line through targetting NF-κB signaling and BACE1

Juan Li, Haitao Wang

Biosci Rep (2018) 38 (6): BSR20180051.

DOI: https://doi.org/10.1042/BSR20180051

Published: 14 November 2018

... precursor protein (APP) to generate Aβ, which stimulates the nuclear transcription factor κB (NF-κB) signaling, leading to the secretion of inflammatory cytokines. And NF-κB can up-regulate the expression of BACE1. miRNAs are small non-coding RNAs that regulate gene transcription. miR-15b down-regulates...

View article titled, miR-15b reduces amyloid-β accumulation in SH-SY5Y cell line through targetting NF-κB signaling and BACE1

Articles

Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3

Zhongbin Xia, Fanru Meng, Ying Liu, Yuxuan Fang, Xia Wu, Chunwang Zhang, Dan Liu, Guoqing Li

Biosci Rep (2018) 38 (4): BSR20180540.

DOI: https://doi.org/10.1042/BSR20180540

Published: 31 July 2018

... the expression of p-IkBα and CD69, and CD25in T cells. MiR-128-3p targets TNFAIP3 to regulate its expression. MiR-128-3p knockdown significantly suppressed the activity of nuclear factor κB (NF-κB) and T cells by up-regulating TNFAIP3, while cells co-transfected with si-TNFAIP3 abolished the effects of MiR-128...

View article titled, Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3

Articles

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Guoqing Li, Zhongbing Xia, Ying Liu, Fanru Meng, Xia Wu, Yuxuan Fang, Chunwang Zhang, Dan Liu

Biosci Rep (2018) 38 (3): BSR20180541.

DOI: https://doi.org/10.1042/BSR20180541

Published: 21 June 2018

... also significantly increased RA-FLS apoptosis and caspase-3 and -8 activity. Focusing on inflammatory phenotypes, we found SIRT1 significantly reduced RA-FLS secretion of TNF-α, IL-6, IL-8, and IL-1β. Mechanistic studies further revealed SIRT1 suppressed NF-κB pathway by reducing p65 protein expression...

View article titled, SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Articles

Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-κB-mediated inflammatory genes

YiFeng Yuan, Sushant K. Das, MaoQuan Li

Biosci Rep (2018) 38 (2): BSR20171294.

DOI: https://doi.org/10.1042/BSR20171294

Published: 05 March 2018

..., reduced inflammatory response was found in VD treatment group. Furthermore, nuclear factor κB (NF-κB) pathway was found to be involved in the process of diabetic wound healing by assessing the relative proteins in diabetic wounds. Vitamin D supplementation obviously suppressed NF-κB pathway activation...

View article titled, Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-κB-mediated inflammatory genes

Articles

Inactivated Lactobacillus promotes protection against myocardial ischemia–reperfusion injury through NF-κB pathway

Ni Wang, Genhong Song, Yang Yang, Weiwei Yuan, Ming Qi

Biosci Rep (2017) 37 (6): BSR20171025.

DOI: https://doi.org/10.1042/BSR20171025

Published: 17 November 2017

... infarction area was determined by TTC staining and myocardial endothelial cell apoptosis rate was determined by Tunel kit. Besides, A20, IκB, nuclear factor (NF)-κB, and nitric oxide (NO) synthase (NOS) were also assayed by Western blot. When compared with model group, Lac obviously reduces MIRI in the rat...

View article titled, Inactivated Lactobacillus promotes protection against myocardial ischemia–reperfusion injury through NF-κB pathway

Articles

ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidized-LDL and TNF-α in primary colon epithelial cells

Ali H. El-Bahrawy, Abdelmetalab Tarhuni, Hogyoung Kim, Venkat Subramaniam, Ilyes Benslimane, Zakaria Y. Abd Elmajeed, Samuel C. Okpechi, Mohamed A. Ghonim, Ramadan A.M. Hemeida, Amira M. Abo-yousef, Gamal A. El-Sherbiny, Ihab T. Abdel-Raheem, Jong Kim, Amarjit S. Naura, A. Hamid Boulares

Biosci Rep (2016) 36 (5): e00388.

DOI: https://doi.org/10.1042/BSR20160195

Published: 06 October 2016

... deficiency in Apolipoprotein E (ApoE) is linked to many diseases, its effect on colon homoeostasis remains unknown. ApoE appears to control inflammation by regulating nuclear factor-κB (NF-κB). The present study was designed to examine whether ApoE deficiency affects factors of colon integrity in vivo...

View article titled, ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidized-LDL and TNF-α in primary colon epithelial cells

Includes: Supplementary data

Articles

Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes

Qingyun Xie, Meng Wei, Xia Kang, Da Liu, Yi Quan, Xianming Pan, Xiling Liu, Dongfa Liao, Jinbiao Liu, Bo Zhang

Biosci Rep (2015) 35 (3): e00204.

DOI: https://doi.org/10.1042/BSR20150071

Published: 11 June 2015

... that miR-26a attenuated saturated free fatty acid-induced activation of NF-κB (p65) and production of proinflammatory cytokines in chondrocytes. Meanwhile, NF-κB (p65) also suppressed miR-26a production by directly binding to a predicted NF-κB binding element in the promoter region of miR-26a . Finally, we...

View article titled, Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes

Articles

Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster

Daniel Bandarra, John Biddlestone, Sharon Mudie, H. Arno Muller, Sonia Rocha

Biosci Rep (2014) 34 (4): e00127.

DOI: https://doi.org/10.1042/BSR20140095

Published: 29 July 2014

... homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-κB (nuclear factor κB). Here we show that hypoxia activates the IKK–NF-κB [IκB (inhibitor of nuclear factor κB)–NF-κB] pathway...

View article titled, Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster

Articles

Apoptosis of Dedifferentiated Hepatoma Cells is Independent of NF-κB Activation in Response to LPS

M. Ryan Reidy, Janette Ellis, Erin A. Schmitz, David M. Kraus, Gary A. Bulla

Biosci Rep (2007) 27 (4-5): 235–246.

DOI: https://doi.org/10.1007/s10540-007-9049-9

Published: 06 August 2007

... recently reported that the dedifferentiated hepatoma cells also exhibit a strong and prolonged NF-κB induction phenotype upon exposure to LPS, suggesting that NF-κB signaling may play a pro-survival role, as reported in several other cell systems. To test the role of NF-κB in preventing LPS-mediated...

View article titled, Apoptosis of Dedifferentiated Hepatoma Cells is Independent of NF-κB Activation in Response to LPS

NARROW

Polypharmacology of ambroxol in the treatment of COVID-19

Retraction: Vitamin D ameliorates impaired wound healing in streptozotocin induced diabetic mice by suppressing NF-κB mediated inflammatory genes expression

Retraction: MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-kB pathway

TNF-α induces AQP4 overexpression in astrocytes through the NF-κB pathway causing cellular edema and apoptosis

Lung-protective effect of Punicalagin on LPS-induced acute lung injury in mice

Expression of Concern: miR-15b Reduces Amyloid-β Accumulation in SH-SY5Y Cell Line through Targeting NF-κB signaling and BACE1

The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K/Akt/NF-κB signal pathway in nasopharynx carcinoma

Sec-O-glucosylhamaudol suppressed inflammatory reaction induced by LPS in RAW264.7 cells through inhibition of NF-κB and MAPKs signaling

Ubiquitin fold modifier 1 activates NF-κB pathway by down-regulating LZAP expression in the macrophage of diabetic mouse model

Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5/NF-κB pathway

Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway

LncRNA SNHG1 alleviates IL-1β-induced osteoarthritis by inhibiting miR-16-5p-mediated p38 MAPK and NF-κB signaling pathways

FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

C-reactive protein promotes inflammation through TLR4/NF-κB/TGF-β pathway in HL-1 cells

MiR-16-5p inhibits breast cancer by reducing AKT3 to restrain NF-κB pathway

Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status

PLCE1 promotes myocardial ischemia–reperfusion injury in H/R H9c2 cells and I/R rats by promoting inflammation

Morusin alleviates mycoplasma pneumonia via the inhibition of Wnt/β-catenin and NF-κB signaling

Fluoxetine suppresses inflammatory reaction in microglia under OGD/R challenge via modulation of NF-κB signaling

Abnormally expressed miR-23b in Chinese Mongolian at high cardiovascular risk may contribute to monocyte/macrophage inflammatory reaction in atherosclerosis

miR-15b reduces amyloid-β accumulation in SH-SY5Y cell line through targetting NF-κB signaling and BACE1

Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3

SIRT1 inhibits rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and inflammatory response via suppressing NF-κB pathway

Vitamin D ameliorates impaired wound healing in streptozotocin-induced diabetic mice by suppressing NF-κB-mediated inflammatory genes

Inactivated Lactobacillus promotes protection against myocardial ischemia–reperfusion injury through NF-κB pathway

ApoE deficiency promotes colon inflammation and enhances the inflammatory potential of oxidized-LDL and TNF-α in primary colon epithelial cells

Reciprocal inhibition between miR-26a and NF-κB regulates obesity-related chronic inflammation in chondrocytes

Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster

Apoptosis of Dedifferentiated Hepatoma Cells is Independent of NF-κB Activation in Response to LPS

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