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Keywords: Mortaparib
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Computational and in vitro experimental analyses of the anti-COVID-19 potential of Mortaparib and Mortaparib Plus

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Coronavirus
Vipul Kumar, Anissa Nofita Sari, Hazna Noor Meidinna, Jaspreet Kaur Dhanjal, Chandru Subramani, Brohmomoy Basu, Sunil C. Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa
Journal: Bioscience Reports
Biosci Rep (2021) 41 (10): BSR20212156.
DOI: https://doi.org/10.1042/BSR20212156
Published: 14 October 2021
...-regulate their expression. Here, we report experimental and computational analyses of two small molecules, Mortaparib and Mortaparib Plus that were initially identified as dual novel inhibitors of mortalin and PARP-1, for their activity against SARS-CoV-2. In silico analyses showed that Mortaparib Plus...
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Includes: Supplementary data
Articles

Computational and in vitro experimental analyses of the Anti-COVID-19 potential of Mortaparib and Mortaparib Plus

Vipul Kumar, Anissa Nofita Sari, Hazna Noor Meidinna, Jaspreet Kaur Dhanjal, Chandru Subramani, Brohmomoy Basu, Sunil C Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa
Journal: Bioscience Reports
Biosci Rep (2021) BSR20212156.
DOI: https://doi.org/10.1042/BCJ20210626
Published: 04 October 2021
... small molecules, Mortaparib and Mortaparib Plus that were initially identified as dual novel inhibitors of mortalin and PARP-1, for their activity against SARS-CoV-2. In silico analyses showed that Mortaparib Plus , but not Mortaparib, stably binds into the catalytic pocket of TMPRSS2. In vitro analysis...
View article titled, Computational and in vitro experimental analyses of the Anti-COVID-19 potential of <span class="search-highlight">Mortaparib</span> and <span class="search-highlight">Mortaparib</span> Plus
Open the PDF for Computational and in vitro experimental analyses of the Anti-COVID-19 potential of <span class="search-highlight">Mortaparib</span> and <span class="search-highlight">Mortaparib</span> Plus in another window