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Keywords: Mitochondria
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Articles
Biosci Rep (2022) 42 (11): BSR20211693.
Published: 10 November 2022
... melanogaster mitochondria nucleic acids The mitochondrial DNA (mtDNA) in flies and humans is highly conserved in terms of gene content, as is in the vast majority of animal species, although genomic structure varies substantially ( Figure 1 ). Its 37 genes encode 24 RNA components...
Includes: Supplementary data
Articles
Biosci Rep (2022) 42 (4): BSR20211813.
Published: 12 April 2022
...Cameron A. Schmidt Mitochondria are central to the physiology and survival of nearly all eukaryotic cells and house diverse metabolic processes including oxidative phosphorylation, reactive oxygen species buffering, metabolite synthesis/exchange, and Ca 2+ sequestration. Mitochondria...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (12): BSR20211191.
Published: 08 December 2021
... with the mitochondria (mt-HK), is a potent modulator of the generation of mitochondrial ROS in the brain. In the present study, we investigated whether dopamine could affect both the activity and redox function of mt-HK in human neural progenitor cells (NPCs). We found that dopamine signaling via D 1 R decreases mt-HK...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20203481.
Published: 27 January 2021
...Li-rong Yan; Ang Wang; Zhi Lv; Yuan Yuan; Qian Xu Background: Mitochondria-nuclear cross-talk and mitochondrial retrograde regulation are involved in the genesis and development of breast cancer (BC). Therefore, mitochondria can be regarded as a promising target for BC therapeutic strategies...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20201289.
Published: 24 November 2020
... protective genes including mitochondrial molecular chaperones and proteases to re-establish protein homeostasis [ 13–15 ]. However, the mechanism of the mammalian mtUPR and regulated transcription factors is still unclear. ATF4 integratad stress responce mitochondria mtUPR Interestingly...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20194404.
Published: 17 April 2020
... differentiation of proliferating myoblasts (PMB) and confluent myoblasts (CMB) but had weak effect on this process once it had been initiated. The transition of mitochondria (MITO) morphology from high efficient filamentary network to low efficient vesicles was triggered by MEHP, implying its negative effects...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (9): BSR20192101.
Published: 16 September 2019
... is its regulation of mitochondrial biology, including biogenesis, metabolism and apoptosis. In addition to regulating the expression of mitochondrial genes encoded in the nucleus, NF-κB signalling components are also found within mitochondria themselves and associated with mitochondrial DNA. However...
Articles
Biosci Rep (2019) 39 (1): BSR20181661.
Published: 18 January 2019
... = 3 experiments are presented as percentages of control. Dashed red lines show putative effects of the indicated OxPhos inhibitors. ( B ) The effect of Minerval exposure time and FCCP levels on the size, or area of solitary mitochondria (red bars) and on the extent of fragmentation from...
Articles
Biosci Rep (2018) 38 (5): BSR20171492.
Published: 02 October 2018
... radical (HOO∙). Their production sites in mitochondria are reviewed. Even though being highly toxic products, ROS seem important in transducing information from dysfunctional mitochondria. Evidences of signal transduction mediated by ROS in mitochondrial deficiency contexts are then presented in different...
Articles
Biosci Rep (2018) 38 (3): BSR20180208.
Published: 29 June 2018
...María Cecilia De Rossi; Valeria Levi; Luciana Bruno Molecular motors play relevant roles on the regulation of mitochondria size and shape, essential properties for the cell homeostasis. In this work, we tracked single rod-shaped mitochondria with nanometer precision to explore the performance...
Includes: Multimedia, Supplementary data
Articles
Biosci Rep (2018) 38 (3): BSR20180503.
Published: 31 May 2018
... cytometric analysis. To examine the cytochrome c release from mitochondria in untreated or Piperine treated cells, cytosolic extracts were prepared using digitonin-permeabilization technique [ 28 ]. Briefly, cells treated with or without Piperine were washed twice with PBS and lysed in ice-cold...
Articles
Biosci Rep (2018) 38 (1): BSR20171666.
Published: 21 February 2018
... of HK2 with the mitochondria through its N-half is proposed to facilitate higher stability on the mitochondria. The identification of structural and biochemical differences between HK2 and other human hexokinase isozymes could potentially be used in the development of new anticancer therapies...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (1): BSR20171533.
Published: 10 January 2018
... access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell differentiation Histone Methylarginine Mitochondria PGC-1a Skeletal muscle Cells were scraped in ice-cold RIPA...
Articles
Biosci Rep (2017) 37 (6): BSR20171006.
Published: 12 December 2017
... 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics esophageal squamous cell carcinoma hypoxia mitochondria...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (3): BSR20170319.
Published: 17 May 2017
... concentrations of TMP for 24 h at 37°C and DMSO worked as a control. Cellular extracts were prepared for Western blot analysis. Lon protease mitochondria mitochondrial DNA mitochondrial transcription factor A Tetramethylpyrazine Protein quality control in mitochondria is essential for proper...
Includes: Supplementary data
Articles
Biosci Rep (2016) 36 (2): e00321.
Published: 15 April 2016
... in the release of large quantities of amino acids, together with the haemoglobin prosthetic group, haem, which decomposes hydroperoxides and propagates oxygen-derived free radicals. Our previous studies demonstrated that reactive oxygen species (ROS) levels were diminished in the mitochondria and midgut...
Articles
Biosci Rep (2016) 36 (2): e00313.
Published: 16 March 2016
...Abena Nsiah-Sefaa; Matthew McKenzie Mitochondria provide the main source of energy to eukaryotic cells, oxidizing fats and sugars to generate ATP. Mitochondrial fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS) are two metabolic pathways which are central to this process. Defects...
Articles
Biosci Rep (2015) 35 (6): e00277.
Published: 22 December 2015
... or indirectly/independently of epigenetics with processes such as post-translational protein modifications in cell signalling (e.g. phosphorylation). Finally, ingestion of metabolites such as B vitamins can directly alter genomic epigenetic state without being processed by the mitochondria. The deeply inter...
Articles
Biosci Rep (2015) 35 (4): e00244.
Published: 28 August 2015
... regeneration Erv essential for respiration and viability fFAD free FAD FOA 5-fluoroorotic acid MIA mitochondrial import and assembly TCEP tris-(2-carboxyethyl) phosphine WT wild-type flavin-adenine dinucleotide (FAD) binding mitochondria protein folding tryptophan...
Includes: Supplementary data
Articles
Biosci Rep (2015) 35 (4): e00237.
Published: 07 August 2015
... healthy controls and compared for significance. ( C ) Monocytes from a single patient's blood and PO-PCF were permeabilized (30 μg/ml saponin) and mitochondria exposed to excess complex I and complex II linked substrates. Complex I-linked OCR (CI) and complex II-linked OCR (CII) were obtained by injection...
Includes: Supplementary data
Articles
Biosci Rep (2015) 35 (3): e00200.
Published: 11 June 2015
... of heart failure [ 16 – 21 ]. Mitochondria in cardiac muscle of individuals with type 2 diabetes mellitus (T2DM) have a decreased capacity for fatty acid-supported respiration [ 22 ]. Additionally, in a mouse model of obesity and diabetes, mitochondria have reduced oxidative capacity [ 23 ]. We therefore...
Includes: Supplementary data
Articles
Biosci Rep (2014) 34 (1): e00092.
Published: 31 January 2014
...Hua Zhao; Kalani Ruberu; Hongyun Li; Brett Garner Cbl (cobalamin) utilization as an enzyme cofactor is dependent on its efficient transit through lysosomes to the cytosol and mitochondria. We have previously proposed that pathophysiological perturbations in lysosomal function may inhibit...
Articles
Biosci Rep (2013) 33 (6): e00080.
Published: 15 November 2013
..., and anabolic pathways that provide precursors for the synthesis of lipids, proteins and DNA. The review will discuss the original ideas of Otto Warburg and how they initially led to the notion that mitochondria of tumour cells were dysfunctional. Data will be presented to show that not only the organelles...
Articles
Biosci Rep (2013) 33 (4): e00052.
Published: 25 July 2013
... in the mitochondria, and some of the reactions overlap with FA β oxidation ( Figure 3 ) [ 15 ]. Enzymes catalysing these common steps were most clearly correlated to Ethe1. As an example, the tissue distribution of Ethe1, SCAD and the committed step in BCAA oxidation, BCKDH (branched-chain keto acid dehydrogenase...
Articles
Biosci Rep (2013) 33 (1): e00008.
Published: 13 December 2012
... and three 40% CR groups) and the CR groups were fed diets containing soya bean oil (also in the control diet), fish oil or lard. The fatty acid composition of the major mitochondrial phospholipid classes, proton leak and H 2 O 2 production were measured in liver mitochondria following 1 month of CR...
Articles
Biosci Rep (2012) 32 (6): 549–557.
Published: 19 September 2012
...J. Ignacio Moreno; Babu Patlolla; Kerry R. Belton; Brenita C. Jenkins; Polina V. Radchenkova; Marta A. Piva Ccm1p is a nuclear-encoded PPR (pentatricopeptide repeat) protein that localizes into mitochondria of Saccharomyces cerevisiae . It was first defined as an essential factor to remove the bI4...
Articles
Biosci Rep (2012) 32 (1): 53–59.
Published: 10 October 2011
...Leopoldo De Meis; Luisa A. Ketzer; Juliana Camacho-Pereira; Antonio Galina The UCP1 [first UCP (uncoupling protein)] that is found in the mitochondria of brown adipocytes [BAT (brown adipose tissue)] regulates the heat production, a process linked to non-shivering thermogenesis. The activity...
Articles
Biosci Rep (2011) 31 (5): 429–437.
Published: 05 August 2011
... mutant form can suppress the processing of the immature form of uMtCK. LRRK2 expression keeps the uMtCK preprotein on the outer mitochondrial membrane instead of entering the mitochondria. In addition, the expression of both wild-type and mutant forms of LRRK2 promotes the interaction between ANT...
Includes: Supplementary data
Articles
Biosci Rep (2011) 31 (2): 87–98.
Published: 29 October 2010
... protein from the mitochondria to the cytoplasm. Histological observation by TUNEL and EM proved that NaHS inhibited cardiac apoptosis in HF hearts and improved mitochondrial derangements, but that PAG aggravated those indices. Hence, H 2 S has protective effects in HF rats. 1 To whom correspondence...
Articles
Biosci Rep (2010) 30 (6): 413–423.
Published: 27 September 2010
... the cold acclimation process. glycolysis goldfish hexokinase (HK) mitochondria skeletal muscle thermal acclimation 1 To whom correspondence should be addressed (email wseixas@bioqmed.ufrj.br ). 16 10 2009 4 1 2010 7 1 2010 7 1 2010 © The Authors Journal...
Articles
Biosci Rep (2009) 29 (6): 351–362.
Published: 22 July 2009
... the purification and characterization of VDAC2 from a mammalian tissue. © The Authors Journal compilation © 2009 Biochemical Society 2009 mitochondria porin isoform purification sequence analysis spermatozoa voltage-dependent anion channel 2 (VDAC2) 1 To whom correspondence should...
Articles
Biosci Rep (2008) 28 (5): 239–249.
Published: 11 September 2008
...Catherine Ross-Inta; Chern-Yi Tsai; Cecilia Giulivi Mitochondria can synthesize a limited number of proteins encoded by mtDNA (mitochondrial DNA) by using their own biosynthetic machinery, whereas most of the proteins in mitochondria are imported from the cytosol. It could be hypothesized...
Includes: Supplementary data
Articles
Biosci Rep (2008) 28 (2): 83–88.
Published: 29 April 2008
... of proton leak by HNE in rat and mouse skeletal muscle mitochondria is dependent on incubation with respiratory substrate. In the presence of HNE, mitochondria energized with succinate became progressively more leaky to protons over time compared with mitochondria in the absence of either HNE or succinate...
Articles
Biosci Rep (2007) 27 (1-3): 87–104.
Published: 13 June 2007
...Lucia Petrozzi; Giulia Ricci; Noemi J. Giglioli; Gabriele Siciliano; Michelangelo Mancuso Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities...
Articles
Biosci Rep (2007) 27 (1-3): 11–21.
Published: 13 June 2007
... of practical tips that should precede data acquisition and subsequent analysis. Furthermore, we discuss the application and feasibility of various techniques and discuss their respective strength and weakness. © 2007 The Biochemical Society 2007 Membrane potential Mitochondria Cells Fluorescent...
Articles
Biosci Rep (2007) 27 (1-3): 165–171.
Published: 13 June 2007
... disorders are also reported. © 2007 The Biochemical Society 2007 Mitochondria Stem cells Differentiation Mitochondrial localization ROS MNGIE MINI REVIEW The Role of Mitochondria in Stem Cell Biology Claudia Nesti Æ Livia Pasquali Æ Francesca Vaglini Æ Gabriele Siciliano Æ Luigi Murri...
Articles
Biosci Rep (2007) 27 (1-3): 139–150.
Published: 13 June 2007
... of exercise training for patients with mtDNA defects, and the prevention of mtDNA disease transmission. © 2007 The Biochemical Society 2007 Mitochondria mtDNA Mutation Heteroplasmy Treatment Exercise Satellite cell ORI GI N A L P A PE R Experimental Strategies Towards Treating Mitochondrial...
Articles
Biosci Rep (2006) 26 (5): 341–367.
Published: 09 November 2006
... 2006 Alzheimer's disease Parkinson's disease Amyotrophic lateral Sclerosis Huntington's disease Prion diseases Neurodegeneration Genetics Mitochondria Environmental factors Abstract Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial...
Articles
Biosci Rep (2006) 26 (3): 231–243.
Published: 18 August 2006
... methanesulfonate (MitoDNP). TPP cations accumulate within mitochondria driven by the membrane potential (Δ ψ ), the predominant component of Δ p . Our hypothesis was that MitoDNP would accumulate in mitochondria at high Δ ψ where it would act as a protonophore, but that at lower Δ ψ the accumulation and uncoupling...
Articles
Biosci Rep (2005) 25 (3-4): 209–226.
Published: 08 June 2005
...Fábio T. S. Nogueira; Jiri Borecký; Aníbal E. Vercesi; Paulo Arruda Uncoupling mitochondrial proteins (UCPs) belong to a discrete family within the mitochondrial anion carrier superfamily. Several uncoupling protein types have been found in mitochondria from mammals and plants, as well as in fishes...
Articles
Biosci Rep (2005) 25 (3-4): 271–286.
Published: 08 June 2005
...Jiří Borecký; Aníbal E. Vercesi Energy-dissipation in plant mitochondria can be mediated by inner membrane proteins via two processes: redox potential-dissipation or proton electrochemical potential-dissipation. Alternative oxidases (AOx) and the plant uncoupling mitochondrial proteins (PUMP...
Articles
Biosci Rep (2004) 24 (2): 117–125.
Published: 01 April 2004
... respiratory activity. The oxidative phosphorylation system dominated in the energy budget of the cell. A procedure was specially design to isolate tightly coupled mitochondria from yeast cells grown at alkaline conditions. The isolated mitochondrial preparations met known criteria of physiological intactness...
Articles
Biosci Rep (2003) 23 (2-3): 103–117.
Published: 01 April 2003
...Vitaly D. Samuilov; Elena M. Lagunova; Dmitry B. Kiselevsky; Elena V. Dzyubinskaya; Yana V. Makarova; Mikhail V. Gusev Mitochondria are known to participate in the initiation of programmed cell death (PCD) in animals and in plants. The role of chloroplasts in PCD is still unknown. We describe a new...
Articles
Biosci Rep (2002) 22 (1): 3–16.
Published: 01 February 2002
...S. Papa; S. Scacco; A.M. Sardanelli; V. Petruzzella; R. Vergari; A. Signorile; Z. Technikova-Dobrova A cAMP-dependent protein kinase (PKA) is localized in mammalian mitochondria with the catalytic site at the matrix side of the membrane where it phosphorylates a number of proteins. One...
Articles
Biosci Rep (2002) 22 (1): 99–113.
Published: 01 February 2002
...Frank Norbert Gellerich; Sonata Trumbeckaite; Jens Rüdiger Opalka; Johannes Frank Gellerich; Ying Chen; Stephan Zierz; Karl Werdan; Christiane Neuhof; Heinz Redl Mitochondria, that provide most of the ATP needed for cell work, and that play numerous specific functions in biosyntheses...
Articles
Biosci Rep (2002) 22 (1): 33–46.
Published: 01 February 2002
... Fatty acid mitochondria UCP2 & 3 uncoupling protein Bioscience Reports, Vol. 22, No. 1, February 2002 ( 2002) MINI REVIEW Reconstitution of Novel Mitochondrial Uncoupling Proteins UCP2 and UCP3 Marke´ta Z a´c kova1 and Petr Jez ek2,3 Receiûed September 13, 2001 Reconstitution of novel...
Articles
Biosci Rep (2002) 22 (1): 47–58.
Published: 01 February 2002
... of cell survival and cell death signals. © 2002 Plenum Publishing Corporation 2002 Apoptosis Bcl-2 mitochondria permeability VDAC Bioscience Reports, Vol. 22, No. 1, February 2002 ( 2002) MINI REVIEW Bcl-2 Family of Proteins: Life-or-Death Switch in Mitochondria Yoshihide Tsujimoto...
Articles
Biosci Rep (2001) 21 (2): 189–194.
Published: 01 April 2001
... mitochondria, which results in hypothermia. © 2001 Plenum Publishing Corporation 2001 Uncoupling proteins thermoregulation fatty acids mitochondria skeletal muscle brown fat Bioscience Reports, Vol. 21, No. 2, April 2001 ( 2001) MINI REVIEW Barbara Cannon s Data on the UCP1-Ablated Mice: Non...
Articles
Biosci Rep (2001) 21 (2): 201–212.
Published: 01 April 2001
...Jirí Borecký; Ivan G. Maia; Paulo Arruda Uncoupling proteins (UCPs) belong to a distinct cluster of the mitochondrial anion carrier family. Up to five different uncoupling protein types were found in mitochondria of mammals and plants, and recently in fishes, fungi and protozoa. They exhibit...
Articles
Biosci Rep (2001) 21 (2): 213–222.
Published: 01 April 2001
... that thermogenesis is restricted not only by a lower-limit size but also by a kinetically-limited stimulation of the mitochondrial respiratory chain. © 2001 Plenum Publishing Corporation 2001 Alternative oxidase uncoupling protein mitochondria Bioscience Reports, Vol. 21, No. 2, April 2001 ( 2001) MINI...