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Keywords: Gene expression
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Articles
Biosci Rep (2022) 42 (1): BSR20211706.
Published: 18 January 2022
... 10 01 2022 © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Asian population estrogen gene expression HER2...
Articles
Biosci Rep (2021) 41 (7): BSR20211241.
Published: 12 July 2021
... in the immune-phenotype gene expression regulatory network. These results provide novel ideas and evidence for HCC regulatory mechanisms that may improve immunotherapy for this cancer. Correspondence: Shuijun Zhang ( zhangshuijun@zzu.edu.cn ) 19 05 2021 28 06 2021 01 07 2021 02 07...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (12): BSR20202672.
Published: 16 December 2020
... treatment decreased oxidative stress (LPO, NO), down-regulation gene expression levels ( TNF-α, IL-1β , and BAX ), and this antileishmanial activity of nanoparticles was associated with enhanced antioxidant enzyme activities. In addition, histopathological evaluation proved the antileishmanial activity...
Articles
Biosci Rep (2020) 40 (9): BSR20201084.
Published: 02 September 2020
... 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene expression genetic variants GWAS Insomnia risk genes sleep disease...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR20200467.
Published: 22 July 2020
... references can be found in Supplementary Materials: Ref_PRL_promoters, which could add more insights into the understanding of the possible mechanism of the decreased PRL expression in VF injury. cell function gene expression signaling pathway Vocal fold injury The vocal fold, as a vocal...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (6): BSR20193938.
Published: 15 June 2020
... and treatment of REPL. The chip data of REPL (GSE63901) were downloaded from the NCBI Gene Expression Omnibus (GEO) database. Weighted Gene Co-Expression Network Analysis (WGCNA) was used to construct a co-expression module for studying the relationship between gene modules and clinical features. In addition...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (5): BSR20200008.
Published: 27 May 2020
... leukemia (AML) patients. Methods: The RNA-seq and clinical data of AML patients were obtained from cBioPortal database. CD37 correlated genes, the expression prolife and survival curve of eight key genes were acquired from Gene Expression Profiling Interactive Analysis (GEPIA) and UALCAN. Pathway...
Articles
Biosci Rep (2020) 40 (5): BSR20192933.
Published: 05 May 2020
... (CC BY) . cell apoptosis gene expression H19 m6A modification miR675 The long noncoding RNA (lncRNA) H19 plays a crucial role in the development of cancer [ 1 ]. miR675, derived from exon 1 of H19 , has been shown to have an oncogenic role in liver cancers [ 2 , 3 ]. Our previous...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (4): BSR20193185.
Published: 21 April 2020
... with BMD risk. Consistently, differential gene expression analysis found that the PPP1CB gene showed significantly higher expression in low BMD samples than that in high BMD samples based on two independent expression datasets ( P = 0.0026 and P = 0.043, respectively). Together, we provide a convergent...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20194296.
Published: 27 March 2020
... were induced remarkable blood oxidative stress damage, histopathological alterations, up-regulation of IL-6, Nrf2 gene expression, and DNA fragmentation in the examined immune organs of the broiler chickens as well as a significant reduction in the antibody titer against Newcastle (ND) and avian...
Articles
Biosci Rep (2019) 39 (6): BSR20190188.
Published: 28 June 2019
...Zongqiang Gao; Chen Duan; Fang-fang Yu; Xiong Guo Kashin–beck disease (KBD) is endemic chronic osteoarthrosis and its pathogenesis is still unclear. The present study aimed to explore differential gene expression in articular cartilage between patients with rheumatoid arthritis (RA) and KBD...
Articles
Biosci Rep (2019) 39 (5): BSR20190235.
Published: 21 May 2019
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Association phenotype analysis dysfunction module disordered molecules gene expression osteosarcoma typing Osteosarcoma is a common primary malignant bone tumor. It is also the most common primary bone tumor...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20180334.
Published: 21 December 2018
.... Figure 1 Results of gene expression analysis: Pik3r1 and Map3k1 ( A ) Semi-quantitative RT-PCR analysis of Pik3r1 and Map3k1 mRNA expressions and their corresponding G3PDH in mammary tissue of control, TOE, DMBA and DMBA treated with TOE groups. ( B ) Densitometric analysis was conducted...
Articles
Biosci Rep (2018) 38 (6): BSR20181015.
Published: 23 November 2018
...). However, the cellular and molecular phenotype of adipose derived stem cells (ADSCs) stromal vascular fraction (SVF) from ED patients remains largely unknown. Herein we compared the global gene expression profile in the SVF from ED patients and healthy individuals and identified altered signaling pathways...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (6): BSR20180548.
Published: 07 November 2018
... with asthma severity or with the response to corticosteroids are still being unraveled. The present study integrated four asthma-related gene expression datasets from the Gene Expression Omnibus and identified immune-gene signatures associated with asthma development, severity, or response to treatment...
Articles
Biosci Rep (2018) 38 (4): BSR20180770.
Published: 31 August 2018
..., EXTL2, and EXTL3. While the expression levels of these enzymes change in tumor cells, little is known how this changes the structure and function of HS. In the present study, we investigated gene expression profiles of the EXT family members, their glycosyltransferase activities and HS structure...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (2): BSR20171361.
Published: 27 April 2018
... 2018 The Author(s). 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Cell culture Geese Granulosa cells Growing characteristics Gene expression...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (2): BSR20171274.
Published: 20 April 2018
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biliary samples gene expression liver samples nafld plant sterols and stanols sitostanol Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver injury in Western countries [ 1 ]. NAFLD can present...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (1): BSR20171252.
Published: 30 January 2018
... pathways associated with adipocyte lineage commitment and maturation are not fully delineated. Thus, we performed global gene expression profiling during adipocyte differentiation of human bone marrow stromal (mesenchymal) stem cells (hMSCs) and identified 2,589 up-regulated and 2,583 down-regulated mRNA...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (4): BSR20170712.
Published: 24 August 2017
... Commons Attribution License 4.0 (CC BY) . CCL2 fractalkine glutaminyl cyclase gene expression ICAM1/CD54 Increased chemokine levels and monocyte activation are common components of the pathogenesis of inflammatory diseases including atherosclerosis and chronic lung diseases. Especially...
Includes: Supplementary data
Articles
Biosci Rep (2017) 37 (2): BSR20160183.
Published: 28 April 2017
...Zhenhua Hu; Wee-Wei Tee Gene expression requires successful communication between enhancer and promoter regions, whose activities are regulated by a variety of factors and associated with distinct chromatin structures; in addition, functionally related genes and their regulatory repertoire tend...
Articles
Biosci Rep (2017) 37 (2): BSR20160362.
Published: 28 April 2017
... 2017 © 2017 The Author(s). 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . chromium development gene expression lipid metabolism PPAR pathway...
Articles
Biosci Rep (2015) 35 (3): e00208.
Published: 11 June 2015
... and distributed under the Creative Commons Attribution Licence 3.0 . Apo (Apolipoprotein)B secretion, as well as albumin secretion, increased in 3D HepG2 and HepaRG spheroids. Liver metabolic gene expression was up-regulated in 3D HepaRG spheroids. These results suggest that hanging drop 3D cultures can...
Articles
Biosci Rep (2011) 31 (5): 391–398.
Published: 05 August 2011
... of different concentrations of ASA were compared in K562 (non-MDR) and Lucena (MDR) cells by analysing cell viability, apoptosis and necrosis, intracellular ROS (reactive oxygen species) formation and bcl-2 , p53 and cox-2 gene expression. ASA inhibited the cellular proliferation or induced toxicity in K562...
Includes: Supplementary data
Articles
Biosci Rep (2011) 31 (5): 411–419.
Published: 05 August 2011
... ] revealed fatty acids as potential structural ligands for HNF4α, and the recent affinity-aided identification of LA (linoleic acid; C 18:2ω−6 ) as an exchangeable, yet non-transactivational endogenous ligand for mammalian HNF4α [ 10 ]. diabetes gene expression hepatocyte nuclear factor 4α (HNF4α...
Includes: Supplementary data
Articles
Biosci Rep (2010) 30 (6): 375–381.
Published: 24 September 2010
... cytometric measurements. The analysis demonstrated significant cell-cycle arrest on MTX treatment. Inhibition of lacZ gene expression was also observed on drug treatment, which implicates its interaction with gene expression. 1 To whom correspondence should be addressed (email asad.k@rediffmail.com...
Includes: Supplementary data
Articles
Biosci Rep (2010) 30 (4): 217–222.
Published: 12 March 2010
... contributed equally to this work. 2 To whom correspondence should be addressed (email weilingfu@yahoo.com ). 27 3 2009 11 6 2009 25 6 2009 25 6 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 demethylation reagent gene expression leukaemia...
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Biosci Rep (2008) 28 (6): 319–326.
Published: 06 November 2008
... gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determine whether the two well characterized proteins MeCP2 (methyl-CpG-binding protein 2) and MBD1 (methyl-CpG-binding domain 1) have distinct or redundant functions, we employed RNAi (RNA...
Articles
Biosci Rep (2001) 21 (1): 55–62.
Published: 01 February 2001
... gene expression in transfected COS cells. This sequence contains GC rich region and several putative promoter elements were present, including Sp1, AP2, cAMP-responsive element, and B-cell-specific activating protein. Analysis of tissue distribution of the GM2 activator protein gene revealed tissue...
Articles
Biosci Rep (1999) 19 (5): 473–483.
Published: 01 October 1999
... conditions and only two of the four tested secretagogues significantly increased mucin secretion. Thus, this in vitro model system may be useful in determining alterations in mucin structure, if any, in lung adenocarcinomas as well as in studying the regulation of mucin gene expression. © 1999 Plenum...
Articles
Biosci Rep (1989) 9 (2): 157–188.
Published: 01 April 1989
..., and in the untranscribed part of the genome. KEY WORDS: matrix hypothesis; morphogenesis; protodynamics; growth control; DNA; genome organisation; gene expression; gene regulation. "In this world, seeds of different kinds, sown at the proper time in the land, even in one field, come forth (each) according to its kind...
Articles
Biosci Rep (1987) 7 (12): 955–963.
Published: 01 December 1987
..., that control of this set of genes must be very precise so that protamine gene expression is permitted only in developing spermatocytes and spermatids. Several unsuccessful attempts have been made to achieve xpression of the cloned Department of Medical Biochemistry, Faculty of Medicine, The University...
Articles
Biosci Rep (1986) 6 (7): 621–631.
Published: 01 July 1986
... and the glucocorticoid dexamethasone both had weak stimulatory effects on the mRNA level. It is concluded that an increase in intracellular cAMP levels is a necessary and perhaps sufficient stimulus for the increase in thermogenin gene expression. However, at least under in vivo conditions, this increase requires...