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Keywords: GWAS
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Biosci Rep (2021) 41 (9): BSR20203672.
Published: 31 August 2021
... monogenic determinant. Recently, genome-wide association studies (GWAS) have revealed how common genetic variability can explain up to 36% of PD heritability and that PD manifestation is often determined by multiple variants at different genetic loci. Thus, one of the current challenges in PD research...
Biosci Rep (2020) 40 (9): BSR20201084.
Published: 02 September 2020
.... In the present study, we integrated GWAS summary statistics ( N =386,533) with two independent brain expression quantitative trait loci (eQTL) datasets ( N =329) to determine whether expression-associated SNPs convey risk to insomnia. Furthermore, we applied numerous bioinformatics analyses to highlight...
Includes: Supplementary data
Biosci Rep (2020) 40 (7): BSR20200068.
Published: 21 July 2020
... GWAS PDGFA polymorphism susceptibility Biliary atresia (BA) is a common and serious pediatric surgical disease characterized by progressive fibrosis of the intrahepatic and extrahepatic bile ducts. The detailed mechanisms of BA is remain uncertain, but may be correlate with genetic defects...
Includes: Supplementary data
Biosci Rep (2020) 40 (4): BSR20193185.
Published: 21 April 2020
...Yu Zhai; Lu Yu; Yang Shao; Jianwei Wang In recent years, multiple genome-wide association studies (GWAS) have identified numerous susceptibility variants and risk genes that demonstrate significant associations with bone mineral density (BMD). However, exploring how these genetic variants...
Includes: Supplementary data