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Keywords: Cyclin D1
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Biosci Rep (2021) 41 (1): BSR20202269.
Published: 29 January 2021
...Ayesha Aftab; Ranjha Khan; Wasim Shah; Muhammad Azhar; Ahsanullah Unar; Hafiz Muhammad Jafar Hussain; Ahmed Waqas CCND1 encodes for Cyclin D1 protein and single-nucleotide polymorphisms (SNPs) can modulate its activity. In the present study, the impact of CCND1 SNPs on structure and/or function...
Includes: Supplementary data
Biosci Rep (2020) 40 (1): BSR20192727.
Published: 02 January 2020
... of Hep3B cells in vitro and in vivo . Mechanistic analysis revealed that ISL inhibited cyclin D1 and up-regulated the proteins P21, P27 that negatively regulate the cell cycle. Furthermore, ISL induced apoptosis while inhibiting cell cycle transition. In addition, phosphatidylinositol 3′-kinase/protein...
Biosci Rep (2019) 39 (9): BSR20190227.
Published: 03 September 2019
.... Mechanistically, circMYLK can serve as a competing endogenous RNA for miR-195 to increase cyclin D1 expression in LSCC, and rescue experiments further showed that restoration of miR-195 could block the oncogenic role of circMYLK in LSCC. In conclusion, our findings indicate that the circMYLK/miR-195/cyclin D1...