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Keywords: Colorectal cancer
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Articles
Biosci Rep (2022) 42 (7): BSR20220078.
Published: 20 July 2022
...Gongmin Zhu; Lijiao Pei; Fan Yang; Chenliang Zhang Background: Colorectal cancer (CRC) is one of the most prevalent malignant cancers worldwide. Immune-related long non-coding RNAs (IRlncRNAs) are proved to be essential in the development and progression of carcinoma. The purpose of the present...
Articles
Biosci Rep (2022) 42 (6): BSR20220465.
Published: 27 June 2022
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . colorectal cancer Prognosis PUNISHER rs12318065 single nucleotide polymorphisms survival Colon cancer (CC...
Articles
Biosci Rep (2022) 42 (5): BSR20212418.
Published: 13 May 2022
... the functional role and mechanisms of LCN2 in tumorigenesis using murine colitis-associated cancer (CAC) models and human colorectal cancer (CRC) cells. Using murine CAC models, we found that LCN2 was preferentially expressed in colonic tissues from CAC models compared with tissues from normal mice. In vitro...
Articles
Biosci Rep (2022) 42 (1): BSR-2019-0249_COR.
Published: 18 January 2022
... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 5-fluorouracil colorectal cancer MicroRNA-543 PTEN The authors...
Articles
Biosci Rep (2021) 41 (12): BSR20212093.
Published: 07 December 2021
... colorectal cancer (CRC). Cancer cells in ascites reflect poor prognosis and serve as a good specimen to study tumour heterogeneity, as they represent a collection of multiple metastatic sites in the peritoneum. In the present study, we have employed single-cell RNA-sequencing (scRNA-seq) to explore...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (10): BSR20210039.
Published: 19 October 2021
...Zuxiong Tang; Yufan Wu; Ding Sun; Xiaofeng Xue; Lei Qin Colorectal cancer (CRC) is highly prevalent worldwide. The relationship between the infiltration of immunocytes in CRC and clinical outcome has been investigated in recent years. The present study aims to construct a new prognostic signature...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (7): BSR20204113.
Published: 26 July 2021
... there is no defined consensus on the composition of a healthy microbiome due to confounding factors such as ethnicity, geographical locations, age and sex, there are undoubtably populations of microbes that are consistently dysregulated in gut diseases including colorectal cancer (CRC). In this review, we discuss...
Articles
Biosci Rep (2021) 41 (7): BSR20211280.
Published: 26 July 2021
...Yu Zhang; Jia Luo; Zhe Liu; Xudong Liu; Ying Ma; Bohang Zhang; Yuxuan Chen; Xiaofeng Li; Zhiguo Feng; Ningning Yang; Dayun Feng; Lei Wang; Xinqiang Song Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated with high mortality. Here we performed bioinformatics...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20181233_COR.
Published: 27 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Celastrol Colorectal cancer ERK Human proteome microarray Shoc2...
Articles
Biosci Rep (2021) 41 (4): BSR20204136.
Published: 22 April 2021
...Danyang Wang; Qingmin Liu; Yanjun Ren; Yan Zhang; Xin Wang; Bing Liu Background: There is accumulating evidence of aberrant expression of miR-143 and miR-145 and their target gene KRAS in colorectal cancer (CRC). We hypothesize that single nucleotide polymorphisms (SNPs) within or near mRNA...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20200098_EOC.
Published: 07 April 2021
... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer FAT4 MicroRNA-106b-5p ...
Articles
Biosci Rep (2021) 41 (4): BSR-20190724_EOC.
Published: 07 April 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer EMT lncRNA The Editorial Office has been made aware...
Articles
Biosci Rep (2021) 41 (3): BSR20202915.
Published: 17 March 2021
...Zoë Jukes; Anne Freier; Maria Glymenaki; Richard Brown; Lee Parry; Elizabeth Want; Panagiotis A. Vorkas; Jia V. Li Inactivating mutations including both germline and somatic mutations in the adenomatous polyposis coli ( APC ) gene drives most familial and sporadic colorectal cancers. Understanding...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20201930.
Published: 14 January 2021
...Wei-Chih Su; Wei-Yu Kao; Tsung-Kun Chang; Hsiang-Lin Tsai; Ching-Wen Huang; Yen-Cheng Chen; Ching-Chun Li; Yi-Chien Hsieh; Hsing-Jung Yeh; Chun-Chao Chang; Jaw-Yuan Wang Despite the steadily increasing worldwide incidence of colorectal cancer (CRC), an effective noninvasive approach for early...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (1): BSR20191729.
Published: 04 January 2021
...Jiakai Jiang; Sheng Zhang; Weifeng Tang; Zhiyuan Qiu Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (11): BSR20200098.
Published: 02 November 2020
...Min Pan; Qiuqiu Chen; Yusong Lu; Feifei Wei; Chunqiao Chen; Guiyan Tang; Hui Huang MicroRNA-106b-5p (miR-106b-5p) is involved in the development of many cancers including colorectal cancer (CRC), and FAT4 is correlated with regulation of growth and apoptosis of cancer cells. The present study aimed...
Articles
Biosci Rep (2020) 40 (10): BSR20200576.
Published: 21 October 2020
...Xiaoyun Zhu; Ruchao Ma; Xin Ma; Gang Yang Colorectal cancer (CRC) is a leading cause of cancer-related deaths across the world. Irinotecan (IRI) is commonly used to treat CRC, and IRI-based chemotherapy is linked with adverse reaction and the efficacy of the treatment regimen. The gene UGT1A1 plays...
Articles
Biosci Rep (2020) 40 (10): BSR20201125.
Published: 21 October 2020
...Ting-ting Hu; Jia-wen Yang; Ye Yan; Ying-ying Chen; Hai-bo Xue; You-qun Xiang; Le-chi Ye Colorectal cancer (CRC) is a common malignant tumor in digestive tract with highly invasive and metastatic capacity. Drug sensitivity remains a significant obstacle to successful chemotherapy in CRC patients...
Articles
Biosci Rep (2020) 40 (9): BSR20200141.
Published: 28 September 2020
...Yong Liu; Chao Li; Lijin Dong; Xuewei Chen; Rong Fan Background: Colorectal cancer (CRC) is the third most lethal malignancy in the world, wherein colon adenocarcinoma (COAD) is the most prevalent type of CRC. Exploring biomarkers is important for the diagnosis, treatment, and prevention of COAD...
Articles
Biosci Rep (2020) 40 (9): BSR20202044.
Published: 01 September 2020
...Peng Wang; Huaixin Zheng; Jiayu Zhang; Yashu Wang; Pingping Liu; Xiaoyan Xuan; Qianru Li; Ying Du Colorectal cancer (CRC) has been one of the most common malignancies worldwide, which tends to get worse for the growth and aging of the population and westernized lifestyle. However...
Articles
Biosci Rep (2020) 40 (8): BSR20201927.
Published: 25 August 2020
...Liang Song; Chen Yang; Xiao-Feng He Background. The presence or absence of glutathione S-transferase M1 gene ( GSTM1 ) and glutathione S-transferase T1 gene ( GSTT1 ) polymorphisms, and their combined effects have been suggested as a risk factor for colorectal cancer (CRC). However, the results...
Articles
Biosci Rep (2020) 40 (7): BSR20201008.
Published: 29 July 2020
...Guanghai Wu; Mei Xue; Yongjie Zhao; Youkui Han; Shuai Zhang; Judong Zhang; Chao Li; Jing Xu Epidemiological studies have suggested inconclusive associations between 25-hydroxyvitamin D (25(OH)D) and survival in patients with colorectal cancer (CRC). The aim of the present study...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR-20191453_RET.
Published: 17 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . colorectal cancer Long noncoding RNA ROR1-AS1 Wnt/β-catenin signaling...
Articles
Biosci Rep (2020) 40 (7): BSR20201503.
Published: 09 July 2020
... of colorectal cancer (CRC). However, the roles of the MCM family in CRC remain largely unknown. Methods: Here, the expression, prognostic significance and functions of the MCM family in CRC were systematically analyzed through a series of online databases including CCLE, Oncomine, HPA, cBioPortal and cancerSEA...
Articles
Biosci Rep (2020) 40 (7): BSR-20191453_EOC.
Published: 07 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Long noncoding RNA ROR1-AS1 colorectal cancer Wnt/β-catenin signaling...
Articles
Biosci Rep (2020) 40 (7): BSR-20200225_RET.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer In silico tools In vitro analysis Lynch syndrome MLH1...
Articles
Biosci Rep (2020) 40 (6): BSR-20200225_EOC.
Published: 24 June 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Colorectal cancer Lynch syndrome WES MLH1 In silico tools In vitro...
Articles
Biosci Rep (2020) 40 (6): BSR20201175.
Published: 24 June 2020
...Gong Zi-chen; Qian Jin; Zhang Yi-na; Wang Wei; Kang Xia; Xu Wei; Wu Juan; Zheng Wei Bone metastasis of colorectal cancer (CRC) cells leads to osteolysis. Aberrant activation of osteoclasts is responsible for bone resorption in tumor. In general, bone marrow-derived monocytes (BMMs) differentiate...
Articles
Biosci Rep (2020) 40 (6): BSR20200225.
Published: 03 June 2020
...Komal Saleem; Tahir Zaib; Wei Ji; Chunhui Zhang; Qian Qin; Yusi Wang; Lidan Xu; Hanfei Yu; Siqi Zhu; Kexian Dong; Shuhan Si; Xueyuan Jia; Jie Wu; Songbin Fu; Wenjing Sun Colorectal cancer (CRC) is the third most developing cancer worldwide and Lynch syndrome (LS) accounts for 3–4% of CRC. Genetic...
Includes: Supplementary data
Articles
Biosci Rep (2020) BSR20200011.
Published: 29 May 2020
... under a Creative Commons licence. colorectal cancer LINC00662 miR-145 c-myc competing endogenous RNAs WITHDRAWN ARTICLE WITHDRAWN: Long intergenic non-coding RNA LINC00662 contributes to malignant growth of colorectal cancer cells by upregulating c-myc via sponging microRNA-145 Zhifeng Yao...
Articles
Biosci Rep (2020) 40 (4): BSR20200390.
Published: 28 April 2020
...Yi Yao; Nan Li Background: Metastasis and chemoresistance indicate a poor prognosis in colorectal cancer (CRC) patients. However, the mechanisms that lead to the development of chemoresistance and metastasis in CRC remain unclear. Materials and methods: We combined clinical and experimental studies...
Articles
Biosci Rep (2020) 40 (4): BSR20200355.
Published: 15 April 2020
...Lin Shen; Chao Li; Na Li; Liangfang Shen; Zhanzhan Li Previous studies from case–control studies failed to draw reliable conclusions regarding the relationship between bowel movement frequency and the risk of colorectal cancer. To further examine this relationship, we collect the data from cohort...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (3): BSR20191481.
Published: 27 March 2020
...Xianjuan Shen; Yajing Xue; Hui Cong; Xudong Wang; Zhiwei Fan; Xiaopeng Cui; Shaoqing Ju Studies have shown that long non-coding RNAs (lncRNAs) play vital roles in the development of cancer, including colorectal cancer (CRC). Our purpose is to validate the diagnostic value of serum differentiation...
Articles
Biosci Rep (2020) 40 (3): BSR20192429.
Published: 20 March 2020
...Rongbiao Ying; Zhiping Wei; Yuxian Mei; Shasha Chen; Liming Zhu Objective: To study the correlation between adenomatous polyposis coli ( APC ) gene 3′ untranslated region (UTR) single nucleotide polymorphisms (SNPs) and their interactions with environmental factors and the risk of colorectal cancer...
Articles
Biosci Rep (2020) 40 (3): BSR-20191139_COR.
Published: 06 March 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . colorectal cancer mRNA profiling lncRNA profiling target gene functional...
Articles
Biosci Rep (2020) 40 (2): BSR20191139.
Published: 14 February 2020
...Zhen-Xu Zhou; Xiao-Ming Chen; Yu-Qi Zhang; Liu Peng; Xiang-Yang Xue; Guo-Xin Li The present study investigated the role of abnormally expressed mRNA and long noncoding RNA (lncRNA) in the development of colorectal cancer (CRC). We used lncRNA sequencing to analyze the transcriptome (mRNA and lncRNA...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (1): BSR20191488.
Published: 17 January 2020
...Guosen Wang; Weiwei Sheng; Jingtong Tang; Xin Li; Jianping Zhou; Ming Dong Serine-arginine protein kinase 2 (SRPK2) is aberrantly expressed in human malignancies including colorectal cancer (CRC). However, little is known about the molecular mechanisms, and the role of SRPK2 in chemosensitivity...
Articles
Biosci Rep (2020) 40 (1): BSR20192774.
Published: 14 January 2020
...Yan Lu; Xiujuan Zhang; Jiayue Wang; Kaoshan Chen Colorectal cancer (CRC) is a leading cause of cancer-related human deaths. The exopolysaccharide (EPS1-1), isolated from Rhizopus nigricans , has been described as exhibiting anti-tumor and pro-apoptotic activity against CRC, although the underlying...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (12): BSR20190730.
Published: 13 December 2019
...Zheng Wang; Xiaoli Tang; Xiaoqing Wu; Meiyuan Yang; Daorong Wang Objectives Mismatch repair (MMR) and Microsatellite instability (MSI) are critical when considering immunotherapy and chemotherapeutic drugs an option for patients with colorectal cancer (CRC). We investigated the consistence of MMR...
Articles
Biosci Rep (2019) 39 (12): BSR20191087.
Published: 06 December 2019
... oncogenes and tumor suppressor genes. One such example, miR-27b-3p, has reportedly been involved in tumor progression in many types of cancer. The aim of the present study was to delve into the role and the underlying mechanism of miR-27b-3p in colorectal cancer (CRC) cells. Methods: In the present study...
Articles
Biosci Rep (2019) 39 (11): BSR20190013.
Published: 26 November 2019
...Haiyang Feng; Rongbiao Ying; Tengjiao Chai; Hailang Chen; Haixing Ju Interleukin (IL)-17 have been reported to be associated with the pathogenesis of colorectal cancer (CRC). Few studies investigated the association between IL-17 gene polymorphisms and risk of CRC with inconsistent findings. Thus...
Articles
Biosci Rep (2019) 39 (11): BSR20191453.
Published: 22 November 2019
...Wei Wang; Weihong Zheng; Lei Zhang; Ke Li Recent studies have discovered that long noncoding RNAs (lncRNAs) play an important role in malignant tumors. In this research, lncRNA ROR1-AS1 was selected to identify how it affects the development of colorectal cancer (CRC). ROR1-AS1 expression...
Articles
Biosci Rep (2019) 39 (11): BSR20191199.
Published: 13 November 2019
...Zhenhua Liu; Ning Wang; Feiqing Wang; Shuaimin Zhang; Jie Ding Long non-coding RNA (lncRNA) plays a key regulatory role in the pathogenesis of colorectal cancer (CRC). In the present study, the specific regulatory role of lncRNA ezrin antisense RNA 1 (EZR-AS1) on CRC was investigated...
Articles
Biosci Rep (2019) 39 (11): BSR20192636.
Published: 13 November 2019
..., rectal cancer; SD, Standard Deviation; SEER, Surveillance, Epidemiology and End Results; NR, not recorded. CEA colorectal cancer Nomogram overall survival Colorectal cancer (CRC) is the fourth most common cancer and ranks second in terms of mortality in the United States [ 1...
Articles
Biosci Rep (2019) 39 (8): BSR20190884.
Published: 13 August 2019
...Jingfeng Zhang; Sifeng Hu; Yansen Li Keratin 18 (KRT18) has been suggested to be overexpressed in most types of human tumor, but the expression pattern of KRT18 in colorectal cancer (CRC) remained unknown. In our research, KRT18 protein expression was markedly increased in CRC cancer tissues...
Articles
Biosci Rep (2019) 39 (8): BSR20180441.
Published: 09 August 2019
..., the biological function of miR-382 in colorectal cancer (CRC) is still largely unknown. Here, we found that miR-382 was down-regulated in human colorectal cancer tissues and cell lines associated with it. MiR-382 inhibited colorectal cancer cell proliferation, migration, invasion, and enhance chemosensitivity...
Articles
Biosci Rep (2019) 39 (7): BSR20181863.
Published: 19 July 2019
...Baochun Wang; Juntao Zeng; Yuren Liu Due to insufficient quantitative evaluation of the clinic-pathological features and prognosis of young colorectal cancer (CRC) with mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRC), the aim of our study was to develop a nomogram to identify...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20190708.
Published: 12 July 2019
...Ming-li Yang; Zhe Huang; Li-na Wu; Rong Wu; Han-xi Ding; Ben-gang Wang Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (7): BSR20190724.
Published: 05 July 2019
...Ying Meng; Feng Yu Although numerous differential long noncoding RNAs (IncRNAs) have been identified, the relationship between lncRNA and colorectal cancer (CRC) still remains largely unclear. In the present study, we investigated the function and provided a possible mechanism of lncRNA FAM3D-AS1...
Articles
Biosci Rep (2019) 39 (5): BSR20180268.
Published: 21 May 2019
... generation by YC-1 or BHA, respectively, decreased SLC34A2-induced EZH2 overexpression. Significantly, SLC34A2-induced EZH2 overexpression promoted the proliferation and chemo-resistance to apoptosis in colorectal cancer (CRC) cells in vitro and in vivo . Altogether, we conclude that the SLC34A2-ROS-HIF-1...
Includes: Supplementary data