... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Chemoresistance Human glioma MicroRNA-302c P-pg Temozolomide...

... commonly used anthracycline chemotherapy agent. However, TNBC has a high recurrence rate after chemotherapy, and the mechanisms of chemoresistance and recurrence are not entirely understood. To study the chemoresistance mechanisms, we first screened compounds on a pirarubicin-resistant cell line (MDA-MB...

...Shuai Wu; Jian Xie; Hao Shi; Zi-wei Wang Objective: Metastasis and chemoresistance indicate treatment fail and progresses in gastric cancer (GC) patients. However, the molecular mechanisms of chemoresistance and metastasis remain unclear in GC. Thus, identifying the biological indicators...

...YiHan Wu; Yuan Yao; YongLi Yun; MeiLing Wang; RunXiu Zhu Increasing evidence indicates that microRNAs (miRNAs) participate in the regulation of chemoresistance in a variety of cancers including glioma. However, the molecular mechanism underlying the development of chemoresistance in glioma...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Breast cancer Chemoresistance Doxorubicin miR-222 Breast cancer is considered as the most common malignant tumor among women worldwide [ 1 ]. Chemotherapy is a crucial option for those patients in late stage...

... function in regulating chemoresistance has not been considered in CRC cells. This study investigated whether the down-regulation of miR-543 expression enhanced 5-fluorouracil (5-FU)-induced apoptosis in HCT8/FU colon cancer cells. In our study, qRT-PCR revealed that miR-543 expression was up-regulated...

... of ANRIL on chemoresistance remains still unknown in colorectal cancer (CRC). Here, we investigated ANRIL expression in 63 cases of colorectal cancer specimens and matched normal tissues. Results revealed that ANRIL was up-regulated in tumor tissues samples from patients with CRC and CRC cell lines...

...Wei-xian Chen; Ling-yun Xu; Qi Qian; Xiao He; Wen-ting Peng; Yu-lan Zhu; Lin Cheng A major cause of failure in chemotherapy is drug resistance of cancer cells. Exosomes have been introduced to spread chemoresistance through delivering miRNAs. However, a systematic evaluation of the exosomal miRNA...

...), and circular RNA (circRNA) have been well-documented to participate in cancer occurrence and progression. Recently, multiple studies have highlighted the key roles of ncRNAs in chemoresistance of HCC. In addition, accumulating evidence has demonstrated that they can serve as biomarkers in diagnosis, treatment...

..., exosomes were characterized by morphology and size distribution. We reinforced the significant role of D/exo in spreading chemoresistance from MCF-7/Doc to recipient sensitive cells after absorption and internalization. DRβ-H could reduce the formation and release of D/exo. Next, we demonstrated that DRβ-H...

... biogenesis conferred resistance to and reduced oxidative stress levels [ 89 ]. Mechanistically, this was proposed to be due to the protection of PUFAs from peroxidation by sequestering these toxic lipid by-products into LDs. cell stress cancer progression chemoresistance lipid droplets Lipids...

...Hanqing Hu; Meng Wang; Xu Guan; Ziming Yuan; Zheng Liu; Chaoxia Zou; Guiyu Wang; Xu Gao; Xishan Wang The adenosine triphosphate-binding cassette (ABC) is a large group of proteins involved in material transportation, cellular homeostasis, and closely associated with chemoresistance. ATP-binding...

... of non-coding RNAs (lncRNAs and miRNAs) in tumor biology, including the chemoresistance of cancers. However, little is known about the role and regulation mechanisms of lncRNA cancer X-inactive specific transcripts (XIST) in glioma tumorigenesis and chemotherapy resistance. In the present study, higher...

... and overall survival (OS) of cervical cancer patients. KIF14 expression levels were significantly increased in cervical cancer tissues compared with matched non-cancerous tissues and it was higher in tissues of patients who are chemoresistant compared with those who are chemosensitive. KIF14 expression...

... and 95% ethanol respectively and stored at −20°C until use. chemoresistance hepatocellular carcinoma (HCC) uncoupling protein 2 (UCP2) gemcitabine The uncoupling protein (UCP) family is a sub-category of mitochondrial anion-carrier proteins super-family and can be found in both animal...

.... cancer chemoresistance chemosensitivity clinical prognosis signal transduction tumour suppressor gene (TSG) Cancer is one of the leading causes of human death worldwide, accounting for 7.6 million deaths each year (World Health Organization, 2008). Various therapies have been developed...