...Ayesha Aftab; Ranjha Khan; Wasim Shah; Muhammad Azhar; Ahsanullah Unar; Hafiz Muhammad Jafar Hussain; Ahmed Waqas CCND1 encodes for Cyclin D1 protein and single-nucleotide polymorphisms (SNPs) can modulate its activity. In the present study, the impact of CCND1 SNPs on structure and/or function...

.... Mechanistically, we examined that miR-33a can inhibit the transcription of IGF1, follistatin (FST) and cyclin D1 (CCND1) by targeting their 3′UTR region in both HEK293T cells and duck myoblasts. Moreover, up-regulation of miR-33a decreased and its down-regulation increased the mRNA expression of PI3K, Akt, mTOR...

...Anum Zehra Naqvi; Ishrat Mahjabeen; Saima Ameen; Malik Waqar Ahmed; Asad Ullah Khan; Zertashia Akram; Mahmood Akhtar Kayani The present study was designed to determine the association between the genetic polymorphisms/expression variations of RB1 and CCND1 genes and brain tumor risk...

... increased the metastatic potential and colony forming ability. Cyclin D1 ( CCND1 ), Ajuba LIM Protein ( AJUBA ), and heart development protein with EGF like domains 1 ( HEG1 ) were identified as common target genes of miR-193b-3p and -5p. A reporter assay and an Ago2-RIP experiment showed that both miRNAs...

...Nisha Thakur; Suchitra Kumari; Ravi Mehrotra Introduction: Association between Cyclin D1 (CCND1) single nucleotide polymorphism (SNP) rs9344 and cancer risk is paradoxical. Thus, we performed a meta-analysis to explore the association between CCND1 variant and overall cancer risk in Indian...