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Keywords: AMPK
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Articles
Biosci Rep (2022) BSR20212549.
Published: 23 May 2022
... expression of adiponectin receptor and cellular uptake of glucose and fatty acids. In addition, adiponectin activated the 5′ adenosine monophosphate activated protein kinase (AMPK) signaling pathway. The above results suggested that adiponectin reduced intracellular lipid content, mainly by binding...
Articles
Biosci Rep (2021) 41 (6): BSR20203639.
Published: 21 June 2021
...) and inactivation of AMP-activated protein kinase (AMPK) pathway, HPA-s were obtained and divided into three groups: Control group: cells were cultured under normal conditions; CIH group: cells were cultured in a three-gas incubator (10% O 2 ); Butyric acid group: 10 mmol/l butyric acid added into cell culture...
Includes: Supplementary data
Articles
Biosci Rep (2021) 41 (4): BSR-20190819_RET.
Published: 22 April 2021
... previously published by Portland Press. AMPK Capsaicin cell invasion cell migration ESCC © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . ...
Articles
Biosci Rep (2020) 40 (11): BSR20200661.
Published: 19 November 2020
... that Sop significantly mitigated TAC-induced heart dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis. Mechanistically, Sop treatment induced a remarkable activation of AMPK/mTORC1-autophagy cascade following sustained hypertrophic stimulation. Importantly, the protective effect of Sop was largely...
Includes: Supplementary data
Articles
Biosci Rep (2020) 40 (7): BSR-20190819_EOC.
Published: 02 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . AMPK Capsaicin cell invasion cell migration ESCC The Editorial...
Articles
Biosci Rep (2020) 40 (1): BSR20192774.
Published: 14 January 2020
... mechanism is poorly understood. Herein, we investigate how EPS1-1 induces apoptosis of CRC cells in vitro and in vivo . Our results show that, in vitro , EPS1-1 suppressed cell growth and facilitated apoptosis in a dose- and time-dependent manner by activating the AMP-activated protein kinase (AMPK) pathway...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (12): BSR20192504.
Published: 13 December 2019
...Xiang-zi Zhang; Mo-han Zhang; Xue-sen Fang; Xiang-shu Cui; Zheng Jin To observe changes in AMP-activated protein kinase (AMPK) activity and phosphorylation changes in AMPK signaling pathway in gastric smooth muscle cells of rats with diabetic gastroparesis (DGP), investigate the effect of AMPK...
Articles
Biosci Rep (2019) 39 (12): BSR20191860.
Published: 04 December 2019
... banding. Four weeks post-surgery, CRA-treated mice developed blunted cardiac hypertrophy, fibrosis, and dysfunction, and showed increased LC3 II and p-AMPK expression. In line with the in vivo studies, CRA also inhibited the hypertrophic response induced by PE stimulation accompanying with increased LC3...
Includes: Supplementary data
Articles
Biosci Rep (2019) 39 (9): BSR20181994.
Published: 03 September 2019
... also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy...
Articles
Biosci Rep (2019) 39 (8): BSR20190819.
Published: 05 August 2019
..., phosphorylated AMPK levels were significantly up-regulated, and this effect was eliminated by the AMPK inhibitor Compound C treatment. In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-κB (NF-κB) through deacetylation, and activate AMPK inducing...
Articles
Biosci Rep (2019) 39 (5): BSR20182378.
Published: 14 May 2019
... molecular mechanisms were also explored in SHSY5Y neuroblastoma cells, ultimately providing clues for novel VD and PD treatments. AMPK Emodin ER-stress senile dementia Zinc Cell viability was assessed as previously described [ 16 ]. Dissociated SH-SY5Y cells were distributed into 96-well...
Articles
Biosci Rep (2019) 39 (4): BSR20181286.
Published: 05 April 2019
...-regulated levels of phosphorylated adenosine 5′-monophoshate-activated protein kinase (p-AMPK), and stimulated expression and translocation of glucose transporter 4 (GLUT4). JTW-medicated serum induced significantly greater up-regulation of p-AMPK and GLUT4 than either RC or cinnamon-medicated serum. JTW...
Articles
Biosci Rep (2019) 39 (2): BSR20181995.
Published: 15 February 2019
... is crucial in addition to hypoglycemic effect before clinical prescription. Adenosine 5′-monophosphate-activated protein kinase (AMPK) is an important cell energy sensor, which plays an important role in regulating myocardial energy metabolism, reducing ischemia and ischemia/reperfusion (I/R) injury...
Articles
Biosci Rep (2019) 39 (1): BSR20181767.
Published: 03 January 2019
... processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ATP production...
Articles
Biosci Rep (2019) 39 (1): BSR20180902.
Published: 03 January 2019
...Ping Sun; Jun-Bo Yin; Li-Hua Liu; Jian Guo; Sheng-Hai Wang; Chun-Hui Qu; Chun-Xia Wang The aim of the present study was to understand the possible role of the Dihydromyricetin (DHM) in Alzheimer’s disease (AD) rat model through regulation of the AMPK/SIRT1 signaling pathway. Rats were divided...
Includes: Supplementary data
Articles
Biosci Rep (2018) 38 (4): BSR20170982.
Published: 18 July 2018
...Yanhui Li; Yan Wang; Man Zou; Cong Chen; Yili Chen; Ruicong Xue; Yugang Dong; Chen Liu AMP-activated protein kinase (AMPK), a serine/threonine protein kinase, has been shown to exert a protective effect against cardiac hypertrophy and heart failure. Our previous reports have demonstrated that AMPK...
Articles
Biosci Rep (2018) 38 (3): BSR20180242.
Published: 08 May 2018
...Audrey E. Brown; Beth Dibnah; Emily Fisher; Julia L. Newton; Mark Walker Skeletal muscle fatigue and post-exertional malaise are key symptoms of myalgic encephalomyelitis (ME)/chronic fatigue syndrome (ME/CFS). We have previously shown that AMP-activated protein kinase (AMPK) activation and glucose...
Includes: Supplementary data
Articles
Biosci Rep (2016) 36 (3): e00346.
Published: 17 June 2016
... phosphorylation of mTOR and decreased phosphorylation of AMPK ( P <0.05). Branched-chain amino transferase 2 (BCAT2) mRNA level was not influenced by DEX ( P >0.05) but was increased by leucine supplementation at a dose of 5 mmol/l ( P <0.05). 1 These authors contributed equally to the study...
Articles
Biosci Rep (2014) 34 (2): e00105.
Published: 15 April 2014
... (circulating tumour cells) are metabolic and genetically heterogeneous. There is now special interest in unravelling the mechanisms that allow the reminiscence of dormant tumour lesions that might be related to late disease progression and increased risk of recurrence. AMPK (AMP-activated protein kinase...