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Cover ImageAPOE is one of the major risk factor genes for late-onset Alzheimer's disease. APOE encodes apolipoprotein E, a secreted protein that is highly expressed by astrocytes and microglia, whilst expression can be induced in neurons. In the study by Muñoz et al., CRISPR/Cas9 genome editing was used as 'molecular scissors' to target the APOE DNA sequence, in order to specifically knock down the expression of apolipoprotein E in neuronal cells. APOE knock down reduced expression of the gene encoding the enzyme that cleaves apolipoprotein E, HTRA1, suggesting a feedback loop between APOE and HTRA1 expression. Read their full article in Bioscience Reports (volume 41, issue 2).Close Modal
The role of EMT-related lncRNA in the process of triple-negative breast cancer metastasis
Biosci Rep (2021) 41 (2): BSR20203121.
Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers
Biosci Rep (2021) 41 (2): BSR20204092.
Development of next-generation antimicrobial hydrogel dressing to combat burn wound infection
Biosci Rep (2021) 41 (2): BSR20203404.
Hepatic endoplasmic reticulum calcium fluxes: effect of free fatty acids and KATP channel involvement
Biosci Rep (2021) 41 (2): BSR20202940.
The regulatory effect of 6-TG on lncRNA–miRNA–mRNA ceRNA network in triple-negative breast cancer cell line
Biosci Rep (2021) 41 (2): BSR20203890.
Predicted the P2RX7 rs3751143 polymorphism is associated with cancer risk: a meta-analysis and systematic review
Biosci Rep (2021) 41 (2): BSR20193877.
Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
Ana C.A. Casarotti; Daniela Teixeira; Ieda M. Longo-Maugeri; Mayari E. Ishimura; Maria E.R. Coste; Henrique T. Bianco; Flavio T. Moreira; Amanda F. Bacchin; Maria C. Izar; Iran Gonçalves, Jr; Adriano Caixeta; Gilberto Szarf; Ibraim M. Pinto; Francisco A. Fonseca
Biosci Rep (2021) 41 (2): BSR20203413.
Phosphatidylserine and phosphatidylethanolamine regulate the structure and function of FVIIa and its interaction with soluble tissue factor
Biosci Rep (2021) 41 (2): BSR20204077.
SNHG15 knockdown inhibits diabetic nephropathy progression in pediatric patients by regulating the miR-141/ICAM-1 axis in vitro
Biosci Rep (2021) 41 (2): BSR20204099.
Uncovering the mechanism of Ge-Gen-Qin-Lian decoction for treating ulcerative colitis based on network pharmacology and molecular docking verification
Biosci Rep (2021) 41 (2): BSR20203565.
Hyperglycemia at admission is a strong predictor of mortality and severe/critical complications in COVID-19 patients: a meta-analysis
Biosci Rep (2021) 41 (2): BSR20203584.
Identification of sulforaphane regulatory network in hepatocytes by microarray data analysis based on GEO database
Biosci Rep (2021) 41 (2): BSR20194464.
An updated meta-analysis showed smoking modify the association of GSTM1 null genotype on the risk of coronary heart disease
Yadong Song; Zhilei Shan; Xiaoli Liu; Xiaomin Chen; Cheng Luo; Liangkai Chen; Yimei Wang; Lin Gong; Liegang Liu; Jiansheng Liang
Biosci Rep (2021) 41 (2): BSR20200490.
Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation
Biosci Rep (2021) 41 (2): BSR20203955.
Exploring the mechanism of aidi injection for lung cancer by network pharmacology approach and molecular docking validation
Biosci Rep (2021) 41 (2): BSR20204062.
Functional expression and localisation of HOPS/TMUB1 in mouse lens
Daniela Bartoli; Danilo Piobbico; Marilena Castelli; Stefania Pieroni; Damiano Scopetti; Simona Ferracchiato; Nicola Di-Iacovo; Carlo Cagini; Giuseppe Servillo; Maria Agnese Della-Fazia
Biosci Rep (2021) 41 (2): BSR20203998.
Correlation of hepcidin and serum ferritin levels in thalassemia patients at Chiang Mai University Hospital
Adisak Tantiworawit; Sujaree Khemakapasiddhi; Thanawat Rattanathammethee; Sasinee Hantrakool; Chatree Chai-Adisaksopha; Ekarat Rattarittamrong; Lalita Norasetthada; Pimlak Charoenkwan; Somdet Srichairatanakool; Kanda Fanhchaksai
Biosci Rep (2021) 41 (2): BSR20203352.
Identification of potential biomarkers associated with immune infiltration in the esophageal carcinoma tumor microenvironment
Biosci Rep (2021) 41 (2): BSR20202439.
Association between microRNA-146a, -499a and -196a-2 SNPs and non-small cell lung cancer: a case–control study involving 2249 subjects
Biosci Rep (2021) 41 (2): BSR20201158.
HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose
Biosci Rep (2021) 41 (2): BSR20202924.
Correlations between glycolysis with clinical traits and immune function in bladder urothelial carcinoma
Biosci Rep (2021) 41 (2): BSR20203982.
Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: a novel cellular model relevant to Alzheimer’s disease research
Biosci Rep (2021) 41 (2): BSR20204243.
Development of a mutation hotspot detection kit for the phenylalanine hydroxylase gene by ARMS-PCR combined with fluorescent probe technology
Rong Qiang; Lin Wang; JinHua He; Wei Jie Xu; Wei Li; Na Cai; Xiao Bin Wang; RuiXue Zhang; Li Ping Zhang; Xiao Ping Ma; Chen Wei; ChengRong Song; WenWen Yu; Xiang Wang; Xu Li
Biosci Rep (2021) 41 (2): BSR20201660.
Integrated bioinformatics analysis identified MTHFD1L as a potential biomarker and correlated with immune infiltrates in hepatocellular carcinoma
Biosci Rep (2021) 41 (2): BSR20202063.
Auditory brainstem responses in aging dark agouti rats
Biosci Rep (2021) 41 (2): BSR20202724.
Assessment of risk factors for postoperative cognitive dysfunction after coronary artery bypass surgery: a single-center retrospective cohort study
Yongtao Sun; Hai Feng; Ting Zou; Ming Hou; Yanwu Jin; Changping Gu; Yuelan Wang; Juan Li; Mengjie Liu; Min Zhang; Yalei Gao
Biosci Rep (2021) 41 (2): BSR20190719.
Preventive role of probiotic bacteria against gastrointestinal diseases in mice caused by Giardia lamblia
Biosci Rep (2021) 41 (2): BSR20204114.
Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer
Biosci Rep (2021) 41 (2): BSR20204086.
Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia
Takuya Morikawa; Hiroaki Ohishi; Kengo Kosaka; Tomofumi Shimojo; Akihiro Nagano; Itsuki Taniguchi; Ryuta Fujioka; Kosei Moriyama; Motoko Unoki; Masatomo Takahashi; Motonao Nakao; Yoshihiro Izumi; Takeshi Bamba; Hiroyuki Sasaki; Shiroh Miura; Hiroki Shibata
Biosci Rep (2021) 41 (2): BSR20204171.
Comprehensive analysis of tumor mutation burden and immune microenvironment in gastric cancer
Jie Yu; QianYun Zhang; MengChuan Wang; SiJia Liang; HongYun Huang; Lang Xie; ChunHui Cui; JinLong Yu
Biosci Rep (2021) 41 (2): BSR20203336.
Prognostic value of miR-142 in solid tumors: a meta-analysis
Rongqiang Liu; Shiyang Zheng; Kang Yu; Yajie Yu; Chenyu Yu; Wenqing Shi; Qianmin Ge; Zhiwei Ye; Yi Shao
Biosci Rep (2021) 41 (2): BSR20204043.
Effects of storage time and temperature on highly multiparametric flow analysis of peripheral blood samples; implications for clinical trial samples
Amelia Jerram; Thomas V. Guy; Lucinda Beutler; Bavani Gunasegaran; Ronald Sluyter; Barbara Fazekas de St Groth; Helen M. McGuire
Biosci Rep (2021) 41 (2): BSR20203827.
Correction: Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6
Biosci Rep (2021) 41 (2): BSR-20202583_COR.
Retraction: LncRNA SRA1 is downregulated in HPV-negative cervical squamous cell carcinoma (CSCC) and regulates cancer cell behaviors
Biosci Rep (2021) 41 (2): BSR-20191226_RET.
ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases
Sarbashri Bank; Subrata Kumar De; Biswabandhu Bankura; Smarajit Maiti; Madhusudan Das; Gausal A Khan
Biosci Rep (2021) 41 (2): BSR20202014.
Expression of Concern
Expression of Concern: Up-regulated ENO1 promotes the bladder cancer cell growth and proliferation via regulating β-catenin
Biosci Rep (2021) 41 (2): BSR-20190503_EOC.
Expression of concern: Evaluation of METase-pemetrexed-loaded PEG-PLGA nanoparticles modified with anti-CD133-scFV for treatment of gastric carcinoma
Biosci Rep (2021) 41 (2): BSR-20171001_EOC.
Expression of Concern: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targeting miR-532-5p
Biosci Rep (2021) 41 (2): BSR-20180538_EOC.
Expression of Concern: Antioxidative and anti-photoaging activities of neferine upon UVA irradiation in human dermal fibroblasts
Biosci Rep (2021) 41 (2): BSR-20181414_EOC.
Expression of Concern: Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-β in insulin-resistant HepG2 cells
Biosci Rep (2021) 41 (2): BSR-20181716_EOC.