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Volume 39, Issue 1

January 2019

Cover Image

Cover Image

A schematic of an influenza virion. In the latest issue of Bioscience Reports (volume 39, issue 1), York et al. review the key findings in influenza N-linked glycosylation research, covering its role in driving evolutionary dynamics, the impact of glycosylation on host immune responses, and the prospects of lectin-based therapies.

ISSN 0144-8463

EISSN 1573-4935

Perspective

Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery

Ser-Xian Phua; Kwok-Fong Chan; Chinh Tran-To Su; Jun-Jie Poh; Samuel Ken-En Gan

Biosci Rep (2019) 39 (1): BSR20181958.

Abstract

View Articletitled, Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery

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Review Articles

AMPK: a therapeutic target of heart failure—not only metabolism regulation

Xuan Li; Jia Liu; Qingguo Lu; Di Ren; Xiaodong Sun; Thomas Rousselle; Yi Tan; Ji Li

Biosci Rep (2019) 39 (1): BSR20181767.

Abstract

View Articletitled, AMPK: a therapeutic target of heart failure—not only metabolism regulation

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NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

Angel L. Pey; Clare F. Megarity; David J. Timson

Biosci Rep (2019) 39 (1): BSR20180459.

Abstract

View Articletitled, NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

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Influenza virus N-linked glycosylation and innate immunity

Ian A. York; James Stevens; Irina V. Alymova

Biosci Rep (2019) 39 (1): BSR20171505.

Abstract

View Articletitled, Influenza virus N-linked glycosylation and innate immunity

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Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

Chia-Hua Wu; Ya Wang; Murong Ma; Adam E. Mullick; Rosanne M. Crooke; Mark J. Graham; Alan Daugherty; Hong S. Lu

Biosci Rep (2019) 39 (1): BSR20180201.

Abstract

View Articletitled, Antisense oligonucleotides targeting angiotensinogen: insights from animal studies

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The state of art of neutrophil extracellular traps in protozoan and helminthic infections

César Díaz-Godínez; Julio C. Carrero

Biosci Rep (2019) 39 (1): BSR20180916.

Abstract

View Articletitled, The state of art of neutrophil extracellular traps in protozoan and helminthic infections

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Congo Red and amyloids: history and relationship

Elmira I. Yakupova; Liya G. Bobyleva; Ivan M. Vikhlyantsev; Alexander G. Bobylev

Biosci Rep (2019) 39 (1): BSR20181415.

Abstract

View Articletitled, Congo Red and amyloids: history and relationship

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Apoptosis and apoptotic body: disease message and therapeutic target potentials

Xuebo Xu; Yueyang Lai; Zi-Chun Hua

Biosci Rep (2019) 39 (1): BSR20180992.

Abstract

View Articletitled, Apoptosis and apoptotic body: disease message and therapeutic target potentials

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Altered expression of long non-coding RNA GAS5 in digestive tumors

Shounan Lu; Zhilei Su; Wen Fu; Zhankun Cui; Xingming Jiang; Sheng Tai

Biosci Rep (2019) 39 (1): BSR20180789.

Abstract

View Articletitled, Altered expression of long non-coding RNA GAS5 in digestive tumors

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Mesenchymal stem cells for inflammatory airway disorders: promises and challenges

Xing-Liang Fan; Zhao Zhang; Chui Yan Ma; Qing-Ling Fu

Biosci Rep (2019) 39 (1): BSR20182160.

Abstract

View Articletitled, Mesenchymal stem cells for inflammatory airway disorders: promises and challenges

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The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders

Yang Du; Yan Cheng; Guanfang Su

Biosci Rep (2019) 39 (1): BSR20180773.

Abstract

View Articletitled, The essential role of tumor suppressor gene ING4 in various human cancers and non-neoplastic disorders

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The molecular basis of transient heme-protein interactions: analysis, concept and implementation

Amelie Wißbrock; Ajay Abisheck Paul George; Hans Henning Brewitz; Toni Kühl; Diana Imhof

Biosci Rep (2019) 39 (1): BSR20181940.

Abstract

View Articletitled, The molecular basis of transient heme-protein interactions: analysis, concept and implementation

Supplementary data

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Commentaries

Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering

Laura M. Machesky

Biosci Rep (2019) 39 (1): BSR20182219.

Abstract

View Articletitled, Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering

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Research Articles

Apoptosis of cardiomyocytes in diabetic cardiomyopathy involves overexpression of glycogen synthase kinase-3β

Wei Wu; Xingxing Liu; Longfei Han

Biosci Rep (2019) 39 (1): BSR20171307.

Abstract

View Articletitled, Apoptosis of cardiomyocytes in diabetic cardiomyopathy involves overexpression of glycogen synthase kinase-3β

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Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410

Wei-Li Sun; Tian Kang; Yuan-Yu Wang; Jian-Ping Sun; Chen Li; Hong-Jiang Liu; Yue Yang; Bao-Hua Jiao

Biosci Rep (2019) 39 (1): BSR20180395.

Abstract

View Articletitled, Long noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410

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Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway

Ping Sun; Jun-Bo Yin; Li-Hua Liu; Jian Guo; Sheng-Hai Wang; Chun-Hui Qu; Chun-Xia Wang

Biosci Rep (2019) 39 (1): BSR20180902.

Abstract

View Articletitled, Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway

Supplementary data

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Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge

Zhenhua Zhang; Yong Wang; Wei Zhang; Junyan Li; Weiliang Liu; Wenming Lu

Biosci Rep (2019) 39 (1): BSR20180941.

Abstract

View Articletitled, Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge

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Prognostic values of F-box members in breast cancer: an online database analysis and literature review

Xiaochen Wang; Tao Zhang; Shizhen Zhang; Jinlan Shan

Biosci Rep (2019) 39 (1): BSR20180949.

Abstract

View Articletitled, Prognostic values of F-box members in breast cancer: an online database analysis and literature review

Supplementary data

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Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor

Ruben Adrian Grosso; Paula Virginia Subirada Caldarone; María Cecilia Sánchez; Gustavo Alberto Chiabrando; María Isabel Colombo; Claudio Marcelo Fader

Biosci Rep (2019) 39 (1): BSR20181156.

Abstract

View Articletitled, Hemin induces autophagy in a leukemic erythroblast cell line through the LRP1 receptor

Supplementary data

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QRREM method for the isolation of high-quality RNA from the complex matrices of coconut

Amjad Iqbal; Yaodong Yang; Rashad Qadri; Yi Wu; Jing Li; Farooq Shah; Muhammad Hamayun; Anwar Hussain

Biosci Rep (2019) 39 (1): BSR20181163.

Abstract

View Articletitled, QRREM method for the isolation of high-quality RNA from the complex matrices of coconut

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Effects of OPRM1 and ABCB1 gene polymorphisms on the analgesic effect and dose of sufentanil after thoracoscopic-assisted radical resection of lung cancer

Zhonghai Zhao; Bin Lv; Xiaodong Zhao; Yunlong Zhang

Biosci Rep (2019) 39 (1): BSR20181211.

Abstract

View Articletitled, Effects of OPRM1 and ABCB1 gene polymorphisms on the analgesic effect and dose of sufentanil after thoracoscopic-assisted radical resection of lung cancer

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Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma

Chengtao Sun; Xianfeng Cheng; Chaoyu Wang; Xi Wang; Bing Xia; Yizhuo Zhang

Biosci Rep (2019) 39 (1): BSR20181293.

Abstract

View Articletitled, Gene expression profiles analysis identifies a novel two-gene signature to predict overall survival in diffuse large B-cell lymphoma

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Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome

Roberta da Silva Filha; Sérgio Veloso Brant Pinheiro; Thiago Macedo e Cordeiro; Victor Feracin; Érica Leandro Marciano Vieira; Aline Silva Miranda; Ana Cristina Simões e Silva

Biosci Rep (2019) 39 (1): BSR20181361.

Abstract

View Articletitled, Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome

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Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway

Yanyuan Zhou; Liang Lv; Qinghua Liu; Jiale Song

Biosci Rep (2019) 39 (1): BSR20181380.

Abstract

View Articletitled, Total flavonoids extracted from Nervilia Fordii function in polycystic ovary syndrome through IL-6 mediated JAK2/STAT3 signaling pathway

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The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration

Junmou Hong; Zhipeng Hu; Qi Wu; Chaoliang Tang; Junxia Hu; Ruoshi Chen; Bowen Li; Zhiwei Wang

Biosci Rep (2019) 39 (1): BSR20181504.

Abstract

View Articletitled, The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration

Supplementary data

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The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease

Jing Zhang; Xiu-ling Liu; Qiao-wei Jia; Chen-hui Zhao; Jie-yin Liu; Feng-hui An; Li-hua Li; Zhao-hong Chen; Lian-sheng Wang; Wen-zhu Ma; Zhi-jian Yang; En-zhi Jia

Biosci Rep (2019) 39 (1): BSR20181510.

Abstract

View Articletitled, The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease

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Functional and structural studies of tolloid-like 1 mutants associated with atrial-septal defect 6

Lukasz Sieron; Marta Lesiak; Izabela Schisler; Zofia Drzazga; Andrzej Fertala; Aleksander L. Sieron

Biosci Rep (2019) 39 (1): BSR20180270.

Abstract

View Articletitled, Functional and structural studies of tolloid-like 1 mutants associated with atrial-septal defect 6

Supplementary data

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A20 rescues hepatocytes from apoptosis through the NF-κB signaling pathway in rats with acute liver failure

Ke-Zhi Li; Zhi-Yi Liao; Yu-Xuan Li; Zhi-Yong Ming; Jian-Hong Zhong; Guo-Bin Wu; Shan Huang; Yin-Ning Zhao

Biosci Rep (2019) 39 (1): BSR20180316.

Abstract

View Articletitled, A20 rescues hepatocytes from apoptosis through the NF-κB signaling pathway in rats with acute liver failure

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Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system

Chiman Song; Namkyoung Kim; Miri Park; Jiyeon Lee; Ki-Bong Oh; Taebo Sim

Biosci Rep (2019) 39 (1): BSR20180793.

Abstract

View Articletitled, Procaspase activating compound 1 controls tetracycline repressor-regulated gene expression system

Supplementary data

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Synthetic bovine lactoferrin peptide Lfampin kills Entamoeba histolytica trophozoites by necrosis and resolves amoebic intracecal infection in mice

César Díaz-Godínez; Ximena González-Galindo; Thuluz Meza-Menchaca; Raúl J. Bobes; Mireya de la Garza; Nidia León-Sicairos; Juan P. Laclette; Julio C. Carrero

Biosci Rep (2019) 39 (1): BSR20180850.

Abstract

View Articletitled, Synthetic bovine lactoferrin peptide Lfampin kills Entamoeba histolytica trophozoites by necrosis and resolves amoebic intracecal infection in mice

Supplementary data

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miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

Kai Liu; Yingang Zhang; Liang Liu; Qiling Yuan

Biosci Rep (2019) 39 (1): BSR20180890.

Abstract

View Articletitled, miR-125 regulates PI3K/Akt/mTOR signaling pathway in rheumatoid arthritis rats via PARP2

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FEZF1-AS1 is a key regulator of cell cycle, epithelial–mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

Yunzhou Cheng

Biosci Rep (2019) 39 (1): BSR20180906.

Abstract

View Articletitled, FEZF1-AS1 is a key regulator of cell cycle, epithelial–mesenchymal transition and Wnt/β-catenin signaling in nasopharyngeal carcinoma cells

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Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice

Cheng Cheng; Huimei Wu; Muzi Wang; Lixia Wang; Hongyun Zou; Shuai Li; Rongyu Liu

Biosci Rep (2019) 39 (1): BSR20181117.

Abstract

View Articletitled, Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice

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LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition

Wei Li; Yubo Zhou

Biosci Rep (2019) 39 (1): BSR20181165.

Abstract

View Articletitled, LRIG1 acts as a critical regulator of melanoma cell invasion, migration, and vasculogenic mimicry upon hypoxia by regulating EGFR/ERK-triggered epithelial–mesenchymal transition

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Metabolomics analysis of gut barrier dysfunction in a trauma-hemorrhagic shock rat model

Zhongqi Li; Jian Li; Shouwei Zhang; Gang Chen; Shaohua Chi; Xugang Li; Fei Guo; Jianbo Zhu; Baoxi Sun

Biosci Rep (2019) 39 (1): BSR20181215.

Abstract

View Articletitled, Metabolomics analysis of gut barrier dysfunction in a trauma-hemorrhagic shock rat model

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MiRNA-575 suppresses angiogenesis by targeting Rab5-MEK-ERK pathway in endothelial cells

Xin Zhao; Yaping Yi; Chao Meng; Ningyuan Fang

Biosci Rep (2019) 39 (1): BSR20181218.

Abstract

View Articletitled, MiRNA-575 suppresses angiogenesis by targeting Rab5-MEK-ERK pathway in endothelial cells

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Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2

Huan-Hong Ji; Lin-Lin Yao; Chang Liu; Xiang-dong Li

Biosci Rep (2019) 39 (1): BSR20181252.

Abstract

View Articletitled, Regulation of Myosin-5b by Rab11a and the Rab11 family interacting protein 2

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TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/β-catenin signaling

Tangzhao Liang; Wenling Gao; Lei Zhu; Jianhua Ren; Hui Yao; Kun Wang; Dehai Shi

Biosci Rep (2019) 39 (1): BSR20181290.

Abstract

View Articletitled, TIMP-1 inhibits proliferation and osteogenic differentiation of hBMSCs through Wnt/β-catenin signaling

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The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer

Yan Jia; Lian-Mei Zhao; Han-Yu Bai; Cong Zhang; Su-Li Dai; Hui-lai Lv; Bao-En Shan

Biosci Rep (2019) 39 (1): BSR20181556.

Abstract

View Articletitled, The tumor-suppressive function of miR-1296-5p by targeting EGFR and CDK6 in gastric cancer

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TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases

Tan Li; Jingjing Jing; Liping Sun; Bo Jiang; Shijie Xin; Jun Yang; Yuan Yuan

Biosci Rep (2019) 39 (1): BSR20181591.

Abstract

View Articletitled, TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases

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LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway

Chunfeng Liu; Lei Ren; Jun Deng; Songping Wang

Biosci Rep (2019) 39 (1): BSR20180999.

Abstract

View Articletitled, LncRNA TP73-AS1 promoted the progression of lung adenocarcinoma via PI3K/AKT pathway

Supplementary data

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Rapid and high efficiency transformation of Chlamydomonas reinhardtii by square-wave electroporation

Liang Wang; Lijing Yang; Xin Wen; Zhuoya Chen; Qiaoying Liang; Jialing Li; Wen Wang

Biosci Rep (2019) 39 (1): BSR20181210.

Abstract

View Articletitled, Rapid and high efficiency transformation of Chlamydomonas reinhardtii by square-wave electroporation

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Rare copy number variants in the genome of Chinese female children and adolescents with Turner syndrome

Li Li; Qingfeng Li; Qiong Wang; Li Liu; Ru Li; Huishu Liu; Yaojuan He; Gendie E. Lash

Biosci Rep (2019) 39 (1): BSR20181305.

Abstract

View Articletitled, Rare copy number variants in the genome of Chinese female children and adolescents with Turner syndrome

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LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis

NingHeng Chen; DeTao Yin; Bing Lun; XueLi Guo

Biosci Rep (2019) 39 (1): BSR20181440.

Abstract

View Articletitled, LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis

Supplementary data

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LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGF-β1

Feng Miao; Ji Chen; Meng Shi; Yang Song; Zhiming Chen; Liewen Pang

Biosci Rep (2019) 39 (1): BSR20181525.

Abstract

View Articletitled, LncRNA HAND2-AS1 inhibits non-small cell lung cancer migration, invasion and maintains cell stemness through the interactions with TGF-β1

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The effect of Euphorbia szovitsii Fisch. & C.A.Mey extract on the viability and the proliferation of MDA-MB-231 cell line

Majid Asadi-Samani; Mahmoud Rafieian-Kopaei; Zahra Lorigooini; Hedayatollah Shirzad

Biosci Rep (2019) 39 (1): BSR20181538.

Abstract

View Articletitled, The effect of Euphorbia szovitsii Fisch. & C.A.Mey extract on the viability and the proliferation of MDA-MB-231 cell line

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Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice

Xing Wang; Jie Chen; Hailou Zhang; Zhiheng Huang; Zhilu Zou; Yin Chen; Lei Sheng; Wenda Xue; Juanjuan Tang; Haoxin Wu; Hongquan Liu; Gang Chen

Biosci Rep (2019) 39 (1): BSR20181539.

Abstract

View Articletitled, Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice

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Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice

Wei Gao; Xianfeng Yu; Jindong Hao; Ling Wang; Minghui Qi; Liang Han; Chao Lin; Dongxu Wang

Biosci Rep (2019) 39 (1): BSR20181730.

Abstract

View Articletitled, Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice

Supplementary data

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Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis

Xue Huang; Shanyu Qin; Yongru Liu; Lin Tao; Haixing Jiang

Biosci Rep (2019) 39 (1): BSR20181750.

Abstract

View Articletitled, Associations of tumor necrosis factor-α polymorphisms with the risk of colorectal cancer: a meta-analysis

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The relationship between tooth loss and mortality from all causes, cardiovascular diseases, and coronary heart disease in the general population: systematic review and dose–response meta-analysis of prospective cohort studies

Juxiang Peng; Jukun Song; Jing Han; Zhu Chen; Xinhai Yin; Jianguo Zhu; Jinlin Song

Biosci Rep (2019) 39 (1): BSR20181773.

Abstract

View Articletitled, The relationship between tooth loss and mortality from all causes, cardiovascular diseases, and coronary heart disease in the general population: systematic review and dose–response meta-analysis of prospective cohort studies

Supplementary data

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Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation

Yun-yun Shao; Zhuang-peng Chang; Yao Cheng; Xin-chun Wang; Jing-ping Zhang; Xiao-juan Feng; Yi-ting Guo; Jun-jin Liu; Rui-gang Hou

Biosci Rep (2019) 39 (1): BSR20181877.

Abstract

View Articletitled, Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-κB activation

Supplementary data

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The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling

Nazima Bashir; Kalist Shagirtha; Vaikundam Manoharan; Selvaraj Miltonprabu

Biosci Rep (2019) 39 (1): BSR20180515.

Abstracts

View Articletitled, The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling

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Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer

David Timothy Gayed; Jayant Wodeyar; Zi-Xiang Wang; Xiang Wei; Yi-Yi Yao; Xiao-Xi Chen; Zhou Du; Ji-Cai Chen

Biosci Rep (2019) 39 (1): BSR20180617.

Abstract

View Articletitled, Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer

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Clinical utility of microRNA-451 as diagnostic biomarker for human cancers

Zhanzhan Li; Yanyan Li; Jun Fu; Na Li; Liangfang Shen

Biosci Rep (2019) 39 (1): BSR20180653.

Abstract

View Articletitled, Clinical utility of microRNA-451 as diagnostic biomarker for human cancers

Supplementary data

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Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidence

Saif Khan; Raju K. Mandal; Abdulbaset Mohamed Elasbali; Sajad A. Dar; Arshad Jawed; Mohd Wahid; Harishankar Mahto; Mohtashim Lohani; Bhartendu Nath Mishra; Naseem Akhter; Ali A. Rabaan; Shafiul Haque

Biosci Rep (2019) 39 (1): BSR20180845.

Abstract

View Articletitled, Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidence

Supplementary data

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Identification of novel pathogenic ABCA4 variants in a Han Chinese family with Stargardt disease

Qin Xiang; Yanna Cao; Hongbo Xu; Yi Guo; Zhijian Yang; Lu Xu; Lamei Yuan; Hao Deng

Biosci Rep (2019) 39 (1): BSR20180872.

Abstract

View Articletitled, Identification of novel pathogenic ABCA4 variants in a Han Chinese family with Stargardt disease

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A trial sequential meta-analysis of TNF-α –308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer

Raju K. Mandal; Munawwar Ali Khan; Arif Hussain; Naseem Akhter; Arshad Jawed; Sajad A. Dar; Mohd Wahid; Aditya K. Panda; Mohtashim Lohani; Bhartendu N. Mishra; Shafiul Haque

Biosci Rep (2019) 39 (1): BSR20181052.

Abstract

View Articletitled, A trial sequential meta-analysis of TNF-α –308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer

Supplementary data

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Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

Dexi Jin; Min Zhang; Hongjun Hua

Biosci Rep (2019) 39 (1): BSR20181074.

Abstract

View Articletitled, Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population

Supplementary data

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LncRNAs, MALAT1 and lnc-DC as potential biomarkers for multiple sclerosis diagnosis

Olfat G. Shaker; Rania H. Mahmoud; Omayma O. Abdelaleem; Enas G. Ibrahem; Abdelrahmaan A. Mohamed; Othman M. Zaki; Noha K. Abdelghaffar; Tarek I. Ahmed; Nada F. Hemeda; Naglaa A. Ahmed; Dina F. Mansour

Biosci Rep (2019) 39 (1): BSR20181335.

Abstract

View Articletitled, LncRNAs, MALAT1 and lnc-DC as potential biomarkers for multiple sclerosis diagnosis

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LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma

Xiao-ming Hou; Shu-qiao Yuan; Da Zhao; Xiao-jun Liu; Xin-an Wu

Biosci Rep (2019) 39 (1): BSR20181476.

Abstract

View Articletitled, LDH-A promotes malignant behavior via activation of epithelial-to-mesenchymal transition in lung adenocarcinoma

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Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

Si Shi; Shaoqing Lei; Chaoliang Tang; Kai Wang; Zhongyuan Xia

Biosci Rep (2019) 39 (1): BSR20181614.

Abstract

View Articletitled, Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

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The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells

Dawei Yang; Hao Zhang; Jianjun Wu; Ruishuang Ma; Zongyu Li; Kunzheng Wang; Fan Yang

Biosci Rep (2019) 39 (1): BSR20181707.

Abstract

View Articletitled, The role of chamaejasmine in cellular apoptosis and autophagy in MG-63 cells

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Methionine synthase A2756G polymorphism influences pediatric acute lymphoblastic leukemia risk: a meta-analysis

Li-Min Ma; Hai-Ping Yang; Xue-Wen Yang; Lin-Hai Ruan

Biosci Rep (2019) 39 (1): BSR20181770.

Abstract

View Articletitled, Methionine synthase A2756G polymorphism influences pediatric acute lymphoblastic leukemia risk: a meta-analysis

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Anticancer effects and underlying mechanism of Colchicine on human gastric cancer cell lines in vitro and in vivo

Tao Zhang; Wei Chen; Xumian Jiang; Lei Liu; Kai Wei; Hansong Du; Hui Wang; Juan Li

Biosci Rep (2019) 39 (1): BSR20181802.

Abstract

View Articletitled, Anticancer effects and underlying mechanism of Colchicine on human gastric cancer cell lines in vitro and in vivo

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miR-221/222 promote tumor growth and suppress apoptosis by targeting lncRNA GAS5 in breast cancer

Yuanyuan Zong; Yazhou Zhang; Xichao Sun; Tao Xu; Xiankui Cheng; Yejun Qin

Biosci Rep (2019) 39 (1): BSR20181859.

Abstract

View Articletitled, miR-221/222 promote tumor growth and suppress apoptosis by targeting lncRNA GAS5 in breast cancer

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Revealing the alternative promoter usage of SAF/MAZ gene by bichromatic fluorescent reporter construct

Jianbo Ren; Dawei Guo; Xiaoyi Wang; Chao Zhang; Bo Wang; Zhe Gao

Biosci Rep (2019) 39 (1): BSR20171668.

Abstract

View Articletitled, Revealing the alternative promoter usage of SAF/MAZ gene by bichromatic fluorescent reporter construct

Supplementary data

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Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis

Xichen Wang; Kang Chen; Haipeng Liu; Zeping Huang; Xiao Chen; Lanning Yin

Biosci Rep (2019) 39 (1): BSR20180618.

Abstract

View Articletitled, Prognostic significance of NEK2 in human solid tumors: a systematic review and meta-analysis

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Genotoxicity and pharmacokinetic characterization of Cereus jamacaru ethanolic extract in rats

Iris Ucella de Medeiros; Rhoza Araújo de Medeiros; Raul Henandes Bortolin; Fernando Márlisson de Queiroz; Vivian Nogueira Silbiger; Stephan Pflugmacher; Aline Schwarz

Biosci Rep (2019) 39 (1): BSR20180672.

Abstract

View Articletitled, Genotoxicity and pharmacokinetic characterization of Cereus jamacaru ethanolic extract in rats

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Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB

Guo-Hua Zhou; Yi-Yu Lu; Jing-Lian Xie; Zi-Kun Gao; Xiao-Bo Wu; Wei-Shen Yao; Wei-Guang Gu

Biosci Rep (2019) 39 (1): BSR20180855.

Abstract

View Articletitled, Overexpression of miR-758 inhibited proliferation, migration, invasion, and promoted apoptosis of non-small cell lung cancer cells by negatively regulating HMGB

Supplementary data

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Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized controlled trial

Lijun Peng; Yan Zhong; Aiping Wang; Zhisheng Jiang

Biosci Rep (2019) 39 (1): BSR20180943.

Abstract

View Articletitled, Probiotics combined with aminosalicylic acid affiliates remission of ulcerative colitis: a meta-analysis of randomized controlled trial

Supplementary data

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Taenia solium glutathione transferase fraction activates macrophages and favors the development of Th1-type response

Vera Teresa Vega-Angeles; Luis I. Terrazas; Yadira Ledesma-Soto; Lucía Jiménez; Abraham Landa

Biosci Rep (2019) 39 (1): BSR20181132.

Abstract

View Articletitled, Taenia solium glutathione transferase fraction activates macrophages and favors the development of Th1-type response

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Increased freedom of movement in the nascent chain results in dynamic changes in the structure of the SecM arrest motif

Hazel A. Bracken; Cheryl A. Woolhead

Biosci Rep (2019) 39 (1): BSR20181246.

Abstract

View Articletitled, Increased freedom of movement in the nascent chain results in dynamic changes in the structure of the SecM arrest motif

Supplementary data

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TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma

Gang Chen; Weicheng Chen; Ming Ye; Weiqiang Tan; Bing Jia

Biosci Rep (2019) 39 (1): BSR20181277.

Abstract

View Articletitled, TRIM59 knockdown inhibits cell proliferation by down-regulating the Wnt/β-catenin signaling pathway in neuroblastoma

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Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6

Xiaohang Hua; Jiangang Chen; Lingli Wu

Biosci Rep (2019) 39 (1): BSR20181369.

Abstract

View Articletitled, Identification of candidate biomarkers associated with apoptosis in melanosis coli: GNG5, LPAR3, MAPK8, and PSMC6

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Associations between polymorphisms of the PDLIM4 gene and susceptibility to osteoporotic fracture in an elderly population of Han Chinese

Jihang Chen; Zheping Hong; Chen Zhao; Qing Bi; Binsong Qiu

Biosci Rep (2019) 39 (1): BSR20181505.

Abstract

View Articletitled, Associations between polymorphisms of the PDLIM4 gene and susceptibility to osteoporotic fracture in an elderly population of Han Chinese

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Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

Wessal Massalha; Mark Markovits; Edward Pichinuk; Yael Feinstein-Rotkopf; Mark Tarshish; Kumudesh Mishra; Victoria Llado; Miguel Weil; Pablo V. Escriba; Or Kakhlon

Biosci Rep (2019) 39 (1): BSR20181661.

Abstract

View Articletitled, Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

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The influence of the stiffness of GelMA substrate on the outgrowth of PC12 cells

Yibing Wu; Yang Xiang; Jiehua Fang; Xiaokeng Li; Zunwen Lin; Guangli Dai; Jun Yin; Peng Wei; Deming Zhang

Biosci Rep (2019) 39 (1): BSR20181748.

Abstract

View Articletitled, The influence of the stiffness of GelMA substrate on the outgrowth of PC12 cells

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The Mycoplasma pneumoniae HapE alters the cytokine profile and growth of human bronchial epithelial cells

Shaoli Li; Guanhua Xue; Hanqing Zhao; Yanling Feng; Chao Yan; Jinghua Cui; Hongmei Sun

Biosci Rep (2019) 39 (1): BSR20182201.

Abstract

View Articletitled, The Mycoplasma pneumoniae HapE alters the cytokine profile and growth of human bronchial epithelial cells

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Protective effects of low-intensity pulsed ultrasound on aluminum overload-induced cerebral damage through epigenetic regulation of brain-derived neurotrophic factor expression

Juan Li; Dong-dong Zhang; Chao-qing Wang; Miao Shi; Liang-liang Wang

Biosci Rep (2019) 39 (1): BSR20181185.

Abstract

View Articletitled, Protective effects of low-intensity pulsed ultrasound on aluminum overload-induced cerebral damage through epigenetic regulation of brain-derived neurotrophic factor expression

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MicroRNA-625 inhibits cell invasion and epithelial–mesenchymal transition by targeting SOX4 in laryngeal squamous cell carcinoma

Yuan Li; Chenjuan Tao; Lili Dai; Caixia Cui; Chaohui Chen; Honglin Wu; Qingyu Wei; Xuehua Zhou

Biosci Rep (2019) 39 (1): BSR20181882.

Abstract

View Articletitled, MicroRNA-625 inhibits cell invasion and epithelial–mesenchymal transition by targeting SOX4 in laryngeal squamous cell carcinoma

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TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case–control study

Peng Liu; Zhenjian Zhuo; Wenya Li; Jiwen Cheng; Haixia Zhou; Jing He; Jiao Zhang; Jiaxiang Wang

Biosci Rep (2019) 39 (1): BSR20181891.

Abstract

View Articletitled, TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case–control study

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FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

Qian Jiang; Li Cheng; Daiyuan Ma; Yanli Zhao

Biosci Rep (2019) 39 (1): BSR20181804.

Abstract

View Articletitled, FBXL19-AS1 exerts oncogenic function by sponging miR-431-5p to regulate RAF1 expression in lung cancer

Supplementary data

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Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population

Wenpeng Hui; Zhong Cao; Xiao Wang; Junfeng Zhu

Biosci Rep (2019) 39 (1): BSR20182228.

Abstract

View Articletitled, Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population

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Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo

Fei Cao; Peng Liu; Xianbin Zhang; Yanfen Hu; Xin Dong; Haidong Bao; Lingkai Kong; Lei Wang; Peng Gong

Biosci Rep (2019) 39 (1): BSR20180787.

Abstract

View Articletitled, Shenqi Fuzheng Injection impairs bile duct ligation-induced cholestatic liver injury in vivo

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Association of the gene polymorphisms of BMPR2, ACVRL1, SMAD9 and their interactions with the risk of essential hypertension in the Chinese Han population

Yunpeng Chen; Chenxi Ye; Jingwen Chen; Dongming Lin; Hao Wang; Shen Wang

Biosci Rep (2019) 39 (1): BSR20181217.

Abstract

View Articletitled, Association of the gene polymorphisms of BMPR2, ACVRL1, SMAD9 and their interactions with the risk of essential hypertension in the Chinese Han population

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Glutathione S-transferase gene polymorphisms and risk of nasal or colorectal polyposis

Yonglan Zhang; Haichao Zhang; Peng Lin; Guimin Zhang

Biosci Rep (2019) 39 (1): BSR20181226.

Abstract

View Articletitled, Glutathione S-transferase gene polymorphisms and risk of nasal or colorectal polyposis

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LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1

Wei Li; Xingyu Wu; Wensheng She

Biosci Rep (2019) 39 (1): BSR20181632.

Abstract

View Articletitled, LncRNA POU3F3 promotes cancer cell migration and invasion in nasopharyngeal carcinoma by up-regulating TGF-β1

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Effects of dietary leucine and phenylalanine on gastrointestinal development and small intestinal enzyme activities in milk-fed holstein dairy calves

Yangchun Cao; Shimin Liu; Xinjian Yang; Long Guo; Chuanjiang Cai; Junhu Yao

Biosci Rep (2019) 39 (1): BSR20181733.

Abstract

View Articletitled, Effects of dietary leucine and phenylalanine on gastrointestinal development and small intestinal enzyme activities in milk-fed holstein dairy calves

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The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture

Zhenhan Deng; Wei Luo; Shanshan Gao; Zhan Liao; Yihe Hu; Hongbo He; Can Zhang; Kanghua Li

Biosci Rep (2019) 39 (1): BSR20181843.

Abstract

View Articletitled, The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture

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HOXD8/DIAPH2-AS1 epigenetically regulates PAX3 and impairs HTR-8/SVneo cell function under hypoxia

Yaling Feng; Jianxia Wang; Yue He; Heng Zhang; Minhui Jiang; Dandan Cao; Aiping Wang

Biosci Rep (2019) 39 (1): BSR20182022.

Abstract

View Articletitled, HOXD8/DIAPH2-AS1 epigenetically regulates PAX3 and impairs HTR-8/SVneo cell function under hypoxia

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Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes

Sheida R. Frolova; Vasili S. Gorbunov; Natalia S. Shubina; Alexander M. Perepukhov; Sandaara G. Romanova; Konstantin I. Agladze

Biosci Rep (2019) 39 (1): BSR20181849.

Abstract

View Articletitled, Stilbene derivative as a photosensitive compound to control the excitability of neonatal rat cardiomyocytes

Supplementary data

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Inhibited corneal neovascularization in rabbits following corneal alkali burn by double-target interference for VEGF and HIF-1α

Ying-Cong Fu; Zhi-Ming Xin

Biosci Rep (2019) 39 (1): BSR20180552.

Abstract

View Articletitled, Inhibited corneal neovascularization in rabbits following corneal alkali burn by double-target interference for VEGF and HIF-1α

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miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6

Shaogang Xu; Xuejian Wu

Biosci Rep (2019) 39 (1): BSR20180921.

Abstract

View Articletitled, miR-134 inhibits chondrogenic differentiation of bone marrow mesenchymal stem cells by targetting SMAD6

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False measurement of glycated hemoglobin in patients without hemoglobin A

Minghuan Suo; Dongmei Wen; Weijia Wang; Decai Zhang; Shengnan Xu; Xia Wang; Ting Hu

Biosci Rep (2019) 39 (1): BSR20180128.

Abstract

View Articletitled, False measurement of glycated hemoglobin in patients without hemoglobin A

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AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells

Larissa Leggieri Coa; Thiago Ferreira Abreu; Alexandre Keiji Tashima; Janaina Green; Renata Castiglioni Pascon; Marcelo Afonso Vallim; Joel Machado-Jr

Biosci Rep (2019) 39 (1): BSR20181312.

Abstract

View Articletitled, AKT/protein kinase B associates with β-actin in the nucleus of melanoma cells

Supplementary data

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Corrections

Correction: Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy

Ying Feng; Ming-yue Jin; Dong-wei Liu; Li Wei

Biosci Rep (2019) 39 (1): BSR-20180815_COR.

Extract

View Articletitled, Correction: Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy

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Correction: The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls

Zhiguo Sheng; Meini Kang; Hao Wang

Biosci Rep (2019) 39 (1): BSR-20180942_COR.

Extract

View Articletitled, Correction: The potential role of MGMT rs12917 polymorphism in cancer risk: an updated pooling analysis with 21010 cases and 34018 controls

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Correction: Fangjing decoction relieves febrile seizure-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway

Biosci Rep (2019) 39 (1): 20181206_COR.

Extract

View Articletitled, Correction: Fangjing decoction relieves febrile seizure-induced hippocampal neuron apoptosis in rats via regulating the Akt/mTOR pathway

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