A C3H/10T1/2 cell line containing an inducible metallothionein-ras hybrid oncogene was conditionally and reversibly transformed upon exposure to zinc ions. Interestingly, although the cell line was fully malignant when expressing only low levels of ras, complete morphological transformation required much higher levels.

Keywords:
c-Ha-ras, metallothionein, oncogene, ras, transformation, tumorigenicity, zinc
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© 1987 Plenum Publishing Corporation
1987
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