In an attempt to understand the hyper-responsiveness to glucocorticoids that is characteristic of genetically obese fa/fa rats, we have measured the levels of free corticosterone in serum from lean and obese rats as well as the number of “cytosolic” and “nuclear” binding sites in livers of these rats. Both the lean and obese rats had similar amounts of free corticosterone available for biological activity at 4 weeks and 10 weeks of age. Measurement of glucocorticoid binding to hepatic glucocorticoid receptors failed to show any differences between genotypes leading to the suggestion that the abnormal glucocorticoid response in obese rats may be due either to post-receptor defects or to a permissive action of the steroid in the expression of the fa/fa genotype.
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Rapid Communication|
November 01 1987
Normal levels of serum corticosterone and hepatic glucocorticoid receptors in obese (fa/fa) rats
Narinder Singh Shargill;
Narinder Singh Shargill
1Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 3TU, UK
1Section of Diabetes and Clinical Nutrition, School of Medicine, University of Southern California, 2025 Zonal Avenue, Los Angeles, CA 90033
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Ibtisam Al-Baker;
Ibtisam Al-Baker
1Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 3TU, UK
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David A. York
David A. York
1Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 3TU, UK
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Publisher: Portland Press Ltd
Received:
October 29 1987
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1987 Plenum Publishing Corporation
1987
Biosci Rep (1987) 7 (11): 843–851.
Article history
Received:
October 29 1987
Citation
Narinder Singh Shargill, Ibtisam Al-Baker, David A. York; Normal levels of serum corticosterone and hepatic glucocorticoid receptors in obese (fa/fa) rats. Biosci Rep 1 November 1987; 7 (11): 843–851. doi: https://doi.org/10.1007/BF01119475
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