Translational control is one of primary regulation mechanisms of gene expression. Eukaryotic translational control mainly occurs at the initiation step, the speed-limiting step, which involves more than ten translation initiation factors [eIFs (eukaryotic initiation factors)]. Changing the level or function of these eIFs results in abnormal translation of specific mRNAs and consequently abnormal growth of cells that leads to human diseases, including cancer. Accumulating evidence from recent studies showed that the expression of many eIFs was associated with malignant transformation, cancer prognosis, as well as gene expression regulation. In the present paper, we perform a critical review of recent advances in understanding the role and mechanism of eIF action in translational control and cancer as well as the possibility of targeting eIFs for therapeutic development.
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Review Article|
October 04 2010
Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments
Ji-Ye Yin;
Ji-Ye Yin
*Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
†Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, People's Republic of China
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Zizheng Dong;
Zizheng Dong
*Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
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Zhao-Qian Liu;
Zhao-Qian Liu
†Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, People's Republic of China
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Jian-Ting Zhang
Jian-Ting Zhang
1
*Department of Pharmacology and Toxicology and IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, U.S.A.
1To whom correspondence should be addressed (email jianzhan@iupui.edu).
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Publisher: Portland Press Ltd
Received:
July 13 2010
Accepted:
August 03 2010
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biosci Rep (2011) 31 (1): 1–15.
Article history
Received:
July 13 2010
Accepted:
August 03 2010
Citation
Ji-Ye Yin, Zizheng Dong, Zhao-Qian Liu, Jian-Ting Zhang; Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments. Biosci Rep 1 February 2011; 31 (1): 1–15. doi: https://doi.org/10.1042/BSR20100077
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