Hepatic endothelial lipase (HEL) activity is as high in the neonatal (1-day old) rat liver as in adults. Most of the HEL activity is located at the capillaries since 75% of the total activity is released by heparin or collagenase perfusion. The residual activity (non-releasable) is located in hepatocytes and not in hemopoietic cells, which are the major cell type in neonatal liver. Per mg of protein, the HEL activity is 50% higher in neonatal than in adult hepatocytes. We suggest that neonatal hepatocytes have an increased capacity to synthesize and secrete HEL activity, so maintaining a high activity in the whole organ. it might contribute to the hepatic uptake of cholesterol from circulating lipoproteins, in a period in which endogenous cholesterol synthesis is known to be inhibited in the liver.
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October 01 1989
Hepatic endothelial lipase activity in neonatal rat liver
Ferran Burgaya;
Ferran Burgaya
1Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071-Barcelona, Spain
1Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071-Barcelona, Spain
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Julia Peinado;
Julia Peinado
1Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071-Barcelona, Spain
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Miquel Llobera;
Miquel Llobera
1Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071-Barcelona, Spain
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Ignasi Ramirez
Ignasi Ramirez
1Unitat de Bioquímica i Biologia Molecular B, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08071-Barcelona, Spain
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Publisher: Portland Press Ltd
Received:
January 24 1989
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© 1989 Plenum Publishing Corporation
1989
Biosci Rep (1989) 9 (5): 559–564.
Article history
Received:
January 24 1989
Citation
Ferran Burgaya, Julia Peinado, Miquel Llobera, Ignasi Ramirez; Hepatic endothelial lipase activity in neonatal rat liver. Biosci Rep 1 October 1989; 9 (5): 559–564. doi: https://doi.org/10.1007/BF01119798
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