C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and many cellular functions in adult tissues. C3G participates in regulating functions that require cytoskeletal remodelling such as adhesion, migration, maintenance of cell junctions, neurite growth and vesicle traffic. C3G is spatially and temporally regulated to act on Ras family GTPases Rap1, Rap2, R-Ras, TC21 and Rho family member TC10. Increased C3G protein levels are associated with differentiation of various cell types, indicating an important role for C3G in cellular differentiation. In signalling pathways, C3G serves functions dependent on catalytic activity as well as protein interaction and can therefore integrate signals necessary for the execution of more than one cellular function. This review summarizes our current knowledge of the biology of C3G with emphasis on its role as a transducer of signals to the actin cytoskeleton. Deregulated C3G may also contribute to pathogenesis of human disorders and therefore could be a potential therapeutic target.
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Review Article|
March 02 2011
Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor
Vegesna Radha;
Vegesna Radha
1
1Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500 007, India
1To whom correspondence should be addressed (e-mail: vradha@ccmb.res.in)
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Aninda Mitra;
Aninda Mitra
1Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500 007, India
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Kunal Dayma;
Kunal Dayma
1Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500 007, India
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Kotagiri Sasikumar
Kotagiri Sasikumar
1Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500 007, India
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Publisher: Portland Press Ltd
Received:
August 17 2010
Revision Received:
October 11 2010
Accepted:
October 13 2010
Online ISSN: 1573-4935
Print ISSN: 0144-8463
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biosci Rep (2011) 31 (4): 231–244.
Article history
Received:
August 17 2010
Revision Received:
October 11 2010
Accepted:
October 13 2010
Citation
Vegesna Radha, Aninda Mitra, Kunal Dayma, Kotagiri Sasikumar; Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor. Biosci Rep 1 August 2011; 31 (4): 231–244. doi: https://doi.org/10.1042/BSR20100094
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