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Biochem Soc Trans (2023) 51 (3): 1213–1224.
Published: 09 June 2023
... stressors remain under investigation. In this review, we highlight the zebrafish, Danio rerio , as a potent model of intestinal epithelial development and function. We describe epithelial composition and key regulators of epithelial renewal to promote the zebrafish as an investigative tool to study...
Biochem Soc Trans (2022) 50 (2): 703–712.
Published: 14 March 2022
... level of active SMAD2/3 induced by TGFβ ligands in HE since the trigger can by limited to a small window of time during HE specification and EHT. Functional studies with morpholino mediated knock down of TgfβRII, TGFβ1a or TGFβ1b or using genetic tgfb1b mutants during zebrafish haematopoiesis...
In CollectionEmbryonic development
Biochem Soc Trans (2019) 47 (2): 713–724.
Published: 05 April 2019
... of developmental genes. Zebrafish, perhaps better known for their strength as a model of embryology and organogenesis during development, are coming to the fore as a powerful model for interpreting the role played by chromatin in gene expression. Several recent advances have shown that zebrafish exhibit both...
Biochem Soc Trans (2015) 43 (4): 537–542.
Published: 03 August 2015
... 11195 zebrafish Based on diverse discoveries that have implicated the dysfunction of mitochondria with disease progression, small-molecule modifiers of mitochondrial function have gained increasing interest as research tools and therapeutics [ 1 ]. Different modalities of mitochondrial biology...
Biochem Soc Trans (2009) 37 (4): 830–837.
Published: 22 July 2009
... is seeking an understanding of the biochemical basis of inflammation resolution, using the zebrafish model system. Zebrafish larvae are transparent, allowing visualization of GFP (green fluorescent protein)-labelled leucocytes during inflammation in vivo , and they can be readily manipulated by a range...
Includes: Multimedia, Supplementary data
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
... with its tyrosine kinase receptors. A number of HS structural features that mediate the specific binding of VEGF 165 , including sulphation requirements, have been determined. In parallel, zebrafish embryos were used as a vertebrate model system to study the role in vascular development of the biosynthetic...
Biochem Soc Trans (2005) 33 (5): 962–966.
Published: 26 October 2005
... in zebrafish, mammalian cell lines and, more recently, mammalian tissues, this view has changed to one where clock organization is now seen as being highly decentralized. It is clear that clocks exist in the peripheral tissues of animals as diverse as Drosophila , zebrafish and mammals. In the case...
Biochem Soc Trans (2004) 32 (5): 797–798.
Published: 26 October 2004
.... Plakoglobin expression and localization were examined at the protein level during zebrafish embryonic development by Western blotting and confocal microscopy. Plakoglobin was expressed throughout embryo development at the protein level. Western blotting revealed that embryonic plakoglobin protein content...