... the haematopoietic fate. Understanding how to modulate the requirement for TGFβ signalling in HSC emergence may have critical implications for the generation of these cells in vitro for therapeutic use. BMP endothelial to haematopoietic transition haemogenic endothelium mouse models TGFβ zebrafish...

... of developmental genes. Zebrafish, perhaps better known for their strength as a model of embryology and organogenesis during development, are coming to the fore as a powerful model for interpreting the role played by chromatin in gene expression. Several recent advances have shown that zebrafish exhibit both...

... 11195 zebrafish Based on diverse discoveries that have implicated the dysfunction of mitochondria with disease progression, small-molecule modifiers of mitochondrial function have gained increasing interest as research tools and therapeutics [ 1 ]. Different modalities of mitochondrial biology...

... is seeking an understanding of the biochemical basis of inflammation resolution, using the zebrafish model system. Zebrafish larvae are transparent, allowing visualization of GFP (green fluorescent protein)-labelled leucocytes during inflammation in vivo , and they can be readily manipulated by a range...

... with its tyrosine kinase receptors. A number of HS structural features that mediate the specific binding of VEGF 165 , including sulphation requirements, have been determined. In parallel, zebrafish embryos were used as a vertebrate model system to study the role in vascular development of the biosynthetic...

... in zebrafish, mammalian cell lines and, more recently, mammalian tissues, this view has changed to one where clock organization is now seen as being highly decentralized. It is clear that clocks exist in the peripheral tissues of animals as diverse as Drosophila , zebrafish and mammals. In the case...

.... Plakoglobin expression and localization were examined at the protein level during zebrafish embryonic development by Western blotting and confocal microscopy. Plakoglobin was expressed throughout embryo development at the protein level. Western blotting revealed that embryonic plakoglobin protein content...