...Kazuaki Yoshioka Phosphatidylinositol 3-kinases (PI3Ks) are critical regulators of many cellular processes including cell survival, proliferation, migration, cytoskeletal reorganization, and intracellular vesicular trafficking. They are a family of lipid kinases that phosphorylate membrane...

... relevant kinase substrates is essential. LRRK2 has been consistently shown to impair various intracellular vesicular trafficking events, and recent studies have shown that LRRK2 can phosphorylate a subset of proteins that are intricately implicated in those processes. In light of these findings, we here...

...) guanine-nucleotide-exchange factor (GEF) Rab Rab membrane receptor vesicular trafficking The Rab family of small Ras-like G-proteins, consisting of 11 members in yeast and more than 60 in humans, are key regulators of intracellular vesicular trafficking in eukaryotic cells (for a recent review...

.... In contrast, an involvement of NCS-1 in the expression and regulation of voltage-gated Ca 2+ channels and K + channels has also been proposed, which may be attributed, at least in part, to the effects of NCS-1 on vesicular trafficking pathways. The present review describes current knowledge about the cellular...