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Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 108–113.
Published: 23 January 2014
...Opher Gileadi Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery...