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Keywords: vascular endothelial growth factor (VEGF)
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1576–1583.
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago and the hypothesis that tumours release growth factors...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
... or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the activity of these agents is not as widespread...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1616–1622.
Published: 17 November 2014
... muscle contraction shear stress skeletal muscle stretch vascular endothelial growth factor (VEGF) Skeletal muscle tissue is highly dependent on an adequate supply of oxygen for energy production. At rest, oxygen uptake by the muscle is approximately 1 ml of oxygen/min per 100 g of tissue...
Articles
SRPK1 inhibition in vivo : modulation of VEGF splicing and potential treatment for multiple diseases
Sebastian Oltean, Melissa Gammons, Richard Hulse, Maryam Hamdollah-Zadeh, Athina Mavrou, Lucy Donaldson, Andrew H. Salmon, Steve J. Harper, Michael R. Ladomery, David O. Bates
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 831–835.
Published: 20 July 2012
... serine–arginine protein kinase 1 (SRPK1) serine/arginine-rich splicing factor 1 (SRSF1) vascular endothelial growth factor (VEGF) SRPK1 was first described in 1994 following the isolation of proteins that bind phosphorylated SR splicing factors in mitotic HeLa cells extracts [ 1 ]. SR proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
..., Germany (email Sina.Koch@mpi-dortmund.mpg.de ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) A vessel wall is composed of an endothelial cells monolayer (intima), lining the lumen of the artery and directly in contact with the circulating blood cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Published: 21 November 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 Delta-like ligand 4 (Dll4) intussusception Notch sprouting vascular endothelial growth factor (VEGF) VEGF (vascular endothelial growth factor-A) is the master regulator of angiogenesis both in physiological...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1576–1582.
Published: 21 November 2011
...). Functional domains shown on full-length RNA. Light-coloured boxes indicate predicted mRNA species (not yet described). placental growth factor (PlGF) pre-eclampsia vascular endothelial growth factor (VEGF) Pre-eclampsia [or PET (pre-eclamptic toxaemia)] occurs in 3–5%] of first...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... to either author (email s.egginton@bham.ac.uk or r.bicknell@bham.ac.uk ). 30 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis pre-eclampsia signalling tissue remodelling vascular endothelial growth factor (VEGF) The plenary lecture...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1654–1658.
Published: 21 November 2011
... (email abanfi@uhbs.ch ). 14 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF) vascular maturation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... platelet-derived growth factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide ligand: class 3 semaphorins, a subtype of a large family of secreted polypeptides...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
... and reproduction in any medium, provided the original work is properly cited. cytokine inflammation pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase receptor-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is an important cause of maternal and perinatal...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... endothelial growth factor (VEGF) The discussion to this point has focused on the way in which VEGF is involved in the angiogenic responses to exercise. Current studies suggest that VEGF may also play a role in the acute blood flow response to exercise. Preliminary data show that when VEGF is knocked out...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
... combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth factor (VEGF) Figure 2 Inhibition of angiogenesis and increase of tumour cell invasion in glioma cells where IRE1 is inhibited ( a and c ) Control. ( b , d , e , f and g ) IRE1 dominant...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... email c.a.staton@shef.ac.uk 6 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) Minimal evidence of the expression and role of Sema3 in physiological...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... vascular endothelial growth factor (VEGF) The major pro-angiogenic VEGFR is VEGFR2 (Flk-1/KDR) [ 5 ]. Much is known of the signalling pathways controlled by VEGFR2; however, it is only relatively recently that the intracellular trafficking of this receptor has been studied in any detail...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1237–1242.
Published: 19 November 2009
... to bind to the cell surface, no signal is initiated. carbon monoxide haem oxygenase-1 (HO-1) pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF) No definitive biomarker exists with the potential for risk...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
... during embryogenesis and in adults. The present review summarizes the current status of therapeutic angiogenesis using VEGF, with special reference to preclinical studies. angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1161–1166.
Published: 19 November 2009
... of VEGF-E, the Orf viral genome is likely to have maintained this gene for a long period of time. angiogenic therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1) Blood vessels...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... To whom correspondence should be addressed (email s.ponnambalam@leeds.ac.uk ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) Studies reviewed in the present paper indicate that the function of Notch signalling is ligand and context dependent. For example, Notch1 signalling activated by Dll4 ligand is essential to determine the fate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1228–1232.
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
... endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) Figure 1 Neovascularization in asthma The pathophysiology of asthma is related to allergy, and/or infections with respiratory viruses. Inhalational exposures with allergens, or virus infections...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 946–949.
Published: 19 September 2008
... email luigi.gnudi@kcl.ac.uk 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 albuminuria blood pressure diabetes kidney disease proteinuria transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) Hypertension...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 701–703.
Published: 20 July 2007
... cathepsin K prostate cancer secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone microenvironment and requires processes such as proteolytic degradation and osteoclastic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
... and their receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1171–1177.
Published: 01 December 2003
... of Essex, Colchester, 2–4 July 2003 10 June 2003 © 2003 Biochemical Society 2003 angiogenesis Flt1 kinase-insert-domain-containing receptor (KDR) mitogen-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) Abbreviations used: eNOS...