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Keywords: vascular endothelial growth factor (VEGF)
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Articles

VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning

Yi Jin, David Kaluza, Lars Jakobsson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1576–1583.
DOI: https://doi.org/10.1042/BST20140231
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
View article titled, VEGF, Notch and TGFβ/BMPs in regulation of sprouting angiogenesis and vascular patterning
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Articles

Exploring the role of endothelium in the tumour response to anti-angiogenic therapy

Yi-Chao He, Michael M. Halford, Marc G. Achen, Steven A. Stacker
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1569–1575.
DOI: https://doi.org/10.1042/BST20140173
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) A high level of vascularization was observed in human tumours more than a century ago and the hypothesis that tumours release growth factors...
View article titled, Exploring the role of endothelium in the tumour response to anti-angiogenic therapy
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Articles

Mechanisms that influence tumour response to VEGF-pathway inhibitors

Neil R. Smith, Stephen R. Wedge, Aurelien Pommier, Simon T. Barry
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1601–1607.
DOI: https://doi.org/10.1042/BST20140261
Published: 17 November 2014
... or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the activity of these agents is not as widespread...
View article titled, Mechanisms that influence tumour response to VEGF-pathway inhibitors
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Articles

Capillary growth in human skeletal muscle: physiological factors and the balance between pro-angiogenic and angiostatic factors

Ylva Hellsten, Birgitte Hoier
Journal: Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1616–1622.
DOI: https://doi.org/10.1042/BST20140197
Published: 17 November 2014
... muscle contraction shear stress skeletal muscle stretch vascular endothelial growth factor (VEGF) Skeletal muscle tissue is highly dependent on an adequate supply of oxygen for energy production. At rest, oxygen uptake by the muscle is approximately 1 ml of oxygen/min per 100 g of tissue...
View article titled, Capillary growth in human skeletal muscle: physiological factors and the balance between pro-angiogenic and angiostatic factors
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Articles

SRPK1 inhibition in vivo : modulation of VEGF splicing and potential treatment for multiple diseases

Sebastian Oltean, Melissa Gammons, Richard Hulse, Maryam Hamdollah-Zadeh, Athina Mavrou, Lucy Donaldson, Andrew H. Salmon, Steve J. Harper, Michael R. Ladomery, David O. Bates
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 831–835.
DOI: https://doi.org/10.1042/BST20120051
Published: 20 July 2012
... serine–arginine protein kinase 1 (SRPK1) serine/arginine-rich splicing factor 1 (SRSF1) vascular endothelial growth factor (VEGF) SRPK1 was first described in 1994 following the isolation of proteins that bind phosphorylated SR splicing factors in mitotic HeLa cells extracts [ 1 ]. SR proteins...
View article titled, SRPK1 inhibition in vivo : modulation of VEGF splicing and potential treatment for multiple diseases
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Articles

Neuropilin signalling in angiogenesis

Sina Koch
Journal: Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 20–25.
DOI: https://doi.org/10.1042/BST20110689
Published: 19 January 2012
..., Germany (email Sina.Koch@mpi-dortmund.mpg.de ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF...
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Articles

Angiogenic properties of the chemokine RANTES/CCL5

Nadine Suffee, Benjamin Richard, Hanna Hlawaty, Olivier Oudar, Nathalie Charnaux, Angela Sutton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
DOI: https://doi.org/10.1042/BST20110651
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) A vessel wall is composed of an endothelial cells monolayer (intima), lining the lumen of the artery and directly in contact with the circulating blood cells...
View article titled, Angiogenic properties of the chemokine RANTES/CCL5
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Articles

To sprout or to split? VEGF, Notch and vascular morphogenesis

Roberto Gianni-Barrera, Marianna Trani, Silvia Reginato, Andrea Banfi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1644–1648.
DOI: https://doi.org/10.1042/BST20110650
Published: 21 November 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 Delta-like ligand 4 (Dll4) intussusception Notch sprouting vascular endothelial growth factor (VEGF) VEGF (vascular endothelial growth factor-A) is the master regulator of angiogenesis both in physiological...
View article titled, To sprout or to split? VEGF, Notch and vascular morphogenesis
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Articles

An unexpected tail of VEGF and PlGF in pre-eclampsia

David O. Bates
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1576–1582.
DOI: https://doi.org/10.1042/BST20110671
Published: 21 November 2011
...). Functional domains shown on full-length RNA. Light-coloured boxes indicate predicted mRNA species (not yet described). placental growth factor (PlGF) pre-eclampsia vascular endothelial growth factor (VEGF) Pre-eclampsia [or PET (pre-eclamptic toxaemia)] occurs in 3–5%] of first...
View article titled, An unexpected tail of VEGF and PlGF in pre-eclampsia
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Articles

Advances in the Cellular and Molecular Biology of Angiogenesis

Stuart Egginton, Roy Bicknell
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1551–1555.
DOI: https://doi.org/10.1042/BST20110749
Published: 21 November 2011
... to either author (email s.egginton@bham.ac.uk or r.bicknell@bham.ac.uk ). 30 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis pre-eclampsia signalling tissue remodelling vascular endothelial growth factor (VEGF) The plenary lecture...
View article titled, Advances in the Cellular and Molecular Biology of Angiogenesis
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Articles

Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis

Silvia Reginato, Roberto Gianni-Barrera, Andrea Banfi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1654–1658.
DOI: https://doi.org/10.1042/BST20110652
Published: 21 November 2011
... (email abanfi@uhbs.ch ). 14 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF) vascular maturation...
View article titled, Taming of the wild vessel: promoting vessel stabilization for safe therapeutic angiogenesis
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Articles

How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns

Ian C. Zachary
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1583–1591.
DOI: https://doi.org/10.1042/BST20110697
Published: 21 November 2011
... platelet-derived growth factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide ligand: class 3 semaphorins, a subtype of a large family of secreted polypeptides...
View article titled, How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
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Articles

Is inflammation the cause of pre-eclampsia?

Wenda Ramma, Asif Ahmed
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1619–1627.
DOI: https://doi.org/10.1042/BST20110672
Published: 21 November 2011
... and reproduction in any medium, provided the original work is properly cited. cytokine inflammation pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase receptor-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is an important cause of maternal and perinatal...
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Articles

The critical role of VEGF in skeletal muscle angiogenesis and blood flow

Peter D. Wagner
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1556–1559.
DOI: https://doi.org/10.1042/BST20110646
Published: 21 November 2011
... endothelial growth factor (VEGF) The discussion to this point has focused on the way in which VEGF is involved in the angiogenic responses to exercise. Current studies suggest that VEGF may also play a role in the acute blood flow response to exercise. Preliminary data show that when VEGF is knocked out...
View article titled, The critical role of VEGF in skeletal muscle angiogenesis and blood flow
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Articles

Inhibition of angiogenesis and the angiogenesis/invasion shift

Andreas Bikfalvi, Michel Moenner, Sophie Javerzat, Sophie North, Martin Hagedorn
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1560–1564.
DOI: https://doi.org/10.1042/BST20110710
Published: 21 November 2011
... combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth factor (VEGF) Figure 2 Inhibition of angiogenesis and increase of tumour cell invasion in glioma cells where IRE1 is inhibited ( a and c ) Control. ( b , d , e , f and g ) IRE1 dominant...
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Articles

Class 3 semaphorins and their receptors in physiological and pathological angiogenesis

Carolyn A. Staton
Journal: Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1565–1570.
DOI: https://doi.org/10.1042/BST20110654
Published: 21 November 2011
... email c.a.staton@shef.ac.uk 6 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) Minimal evidence of the expression and role of Sema3 in physiological...
View article titled, Class 3 semaphorins and their receptors in physiological and pathological angiogenesis
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Articles

VEGF receptor trafficking in angiogenesis

Alice Scott, Harry Mellor
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1184–1188.
DOI: https://doi.org/10.1042/BST0371184
Published: 19 November 2009
... vascular endothelial growth factor (VEGF) The major pro-angiogenic VEGFR is VEGFR2 (Flk-1/KDR) [ 5 ]. Much is known of the signalling pathways controlled by VEGFR2; however, it is only relatively recently that the intracellular trafficking of this receptor has been studied in any detail...
View article titled, VEGF receptor trafficking in angiogenesis
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Articles

Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?

Asif Ahmed, Melissa J. Cudmore
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1237–1242.
DOI: https://doi.org/10.1042/BST0371237
Published: 19 November 2009
... to bind to the cell surface, no signal is initiated. carbon monoxide haem oxygenase-1 (HO-1) pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF) No definitive biomarker exists with the potential for risk...
View article titled, Can the biology of VEGF and haem oxygenases help solve pre-eclampsia?
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Articles

Gene therapy with vascular endothelial growth factors

Seppo Ylä-Herttuala
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1198–1200.
DOI: https://doi.org/10.1042/BST0371198
Published: 19 November 2009
... during embryogenesis and in adults. The present review summarizes the current status of therapeutic angiogenesis using VEGF, with special reference to preclinical studies. angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF...
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Articles

The role of neuropilins in cell signalling

Ian C. Zachary, Paul Frankel, Ian M. Evans, Caroline Pellet-Many
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1171–1178.
DOI: https://doi.org/10.1042/BST0371171
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
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Articles

Unique signal transduction of the VEGF family members VEGF-A and VEGF-E

Masabumi Shibuya
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1161–1166.
DOI: https://doi.org/10.1042/BST0371161
Published: 19 November 2009
... of VEGF-E, the Orf viral genome is likely to have maintained this gene for a long period of time. angiogenic therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1) Blood vessels...
View article titled, Unique signal transduction of the VEGF family members VEGF-A and VEGF-E
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Articles

VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis

Alexander F. Bruns, Leyuan Bao, John H. Walker, Sreenivasan Ponnambalam
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1193–1197.
DOI: https://doi.org/10.1042/BST0371193
Published: 19 November 2009
... To whom correspondence should be addressed (email s.ponnambalam@leeds.ac.uk ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF...
View article titled, VEGF-A-stimulated signalling in endothelial cells via a dual receptor tyrosine kinase system is dependent on co-ordinated trafficking and proteolysis
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Articles

VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus

Johannes Waltenberger
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1167–1170.
DOI: https://doi.org/10.1042/BST0371167
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...
View article titled, VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
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Articles

Notch signalling in ischaemia-induced angiogenesis

Ayman Al Haj Zen, Paolo Madeddu
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1221–1227.
DOI: https://doi.org/10.1042/BST0371221
Published: 19 November 2009
... signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) Studies reviewed in the present paper indicate that the function of Notch signalling is ligand and context dependent. For example, Notch1 signalling activated by Dll4 ligand is essential to determine the fate...
View article titled, Notch signalling in ischaemia-induced angiogenesis
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Articles

Neuropilin ligands in vascular and neuronal patterning

Alessandro Fantin, Charlotte H. Maden, Christiana Ruhrberg
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1228–1232.
DOI: https://doi.org/10.1042/BST0371228
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
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Articles

Angioplasticity in asthma

Kewal Asosingh, Serpil C. Erzurum
Journal: Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 805–810.
DOI: https://doi.org/10.1042/BST0370805
Published: 22 July 2009
... endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) Figure 1 Neovascularization in asthma The pathophysiology of asthma is related to allergy, and/or infections with respiratory viruses. Inhalational exposures with allergens, or virus infections...
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Articles

Molecular mechanisms of proteinuria in diabetes

Luigi Gnudi
Journal: Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 946–949.
DOI: https://doi.org/10.1042/BST0360946
Published: 19 September 2008
... email luigi.gnudi@kcl.ac.uk 30 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 albuminuria blood pressure diabetes kidney disease proteinuria transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) Hypertension...
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Articles

Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?

I. Podgorski, B.E. Linebaugh, B.F. Sloane
Journal: Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 701–703.
DOI: https://doi.org/10.1042/BST0350701
Published: 20 July 2007
... cathepsin K prostate cancer secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone microenvironment and requires processes such as proteolytic degradation and osteoclastic...
View article titled, Cathepsin K in the bone microenvironment: link between obesity and prostate cancer?
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Articles

The role of heparan sulphate proteoglycans in angiogenesis

S.E. Stringer
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 451–453.
DOI: https://doi.org/10.1042/BST0340451
Published: 22 May 2006
... and their receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
View article titled, The role of heparan sulphate proteoglycans in angiogenesis
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Articles

VEGF signalling: integration and multi-tasking in endothelial cell biology

I. Zachary
Journal: Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1171–1177.
DOI: https://doi.org/10.1042/bst0311171
Published: 01 December 2003
... of Essex, Colchester, 2–4 July 2003 10 June 2003 © 2003 Biochemical Society 2003 angiogenesis Flt1 kinase-insert-domain-containing receptor (KDR) mitogen-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) Abbreviations used: eNOS...
View article titled, VEGF signalling: integration and multi-tasking in endothelial cell biology
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