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Keywords: vascular endothelial growth factor (VEGF)
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Articles
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) The mechanisms by which anti-angiogenic agents exert their anti-tumour effects still remain largely elusive [ 36 , 37 ]. These inhibitors were...
Articles
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
... or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the activity of these agents is not as widespread...
Articles
Biochem Soc Trans (2014) 42 (6): 1576–1583.
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
Articles
Biochem Soc Trans (2014) 42 (6): 1616–1622.
Published: 17 November 2014
... vascular endothelial growth factor (VEGF) Skeletal muscle tissue is highly dependent on an adequate supply of oxygen for energy production. At rest, oxygen uptake by the muscle is approximately 1 ml of oxygen/min per 100 g of tissue, whereas during intense contraction, oxygen uptake can increase 30...
Articles
Biochem Soc Trans (2012) 40 (4): 831–835.
Published: 20 July 2012
... macular degeneration N. Engl. J. Med. 2004 351 2805 2816 19 Schrijvers B.F. Flyvbjerg A. De Vriese A.S. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology Kidney Int. 2004 65 2003 2017 20 Marrelli A. Cipriani P. Liakouli V...
Articles
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
..., Germany (email Sina.Koch@mpi-dortmund.mpg.de ). 4 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis anti-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF...
Articles
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) The lesions of atherosclerosis mostly occur in large or medium-sized elastic and muscular arteries. Many studies have demonstrated that atherosclerosis...
Articles
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Published: 21 November 2011
.... Kloner R.A. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat: angiogenesis and angioma formation J. Am. Coll. Cardiol. 2000 35 1323 1330 9 Gupta R. Tongers J. Losordo...
Articles
Biochem Soc Trans (2011) 39 (6): 1576–1582.
Published: 21 November 2011
.... Thadhani R. Sachs B.P. Epstein F.H. Circulating angiogenic factors and the risk of preeclampsia N. Engl. J. Med. 2004 350 672 683 9 Chung J.Y. Song Y. Wang Y. Magness R.R. Zheng J. Differential expression of vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... angiogenesis pre-eclampsia signalling tissue remodelling vascular endothelial growth factor (VEGF) The PPARs belong to the nuclear receptor superfamily of ligand-activated transcription factors. The article by David Bishop-Bailey [ 8 ] focuses on the emerging roles of the PPARs in angiogenesis...
Articles
Biochem Soc Trans (2011) 39 (6): 1654–1658.
Published: 21 November 2011
... correspondence should be addressed (email abanfi@uhbs.ch ). 14 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... platelet-derived growth factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide ligand: class 3 semaphorins, a subtype of a large family of secreted polypeptides...
Articles
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
.... Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria J. Biol. Chem. 2003 278 12605 12608 110 Saito S. Shiozaki A. Nakashima A. Sakai M. Sasaki Y. The role of the immune system...
Articles
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
...-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1 ] reported the discovery of a new molecule they called VPF (vascular permeability factor). It was later renamed VEGF (vascular endothelial growth factor) [ 2 ]. This molecule became the subject...
Articles
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
... correspondence should be addressed (email a.bikfalvi@angio.u-bordeaux1.fr ). 12 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis chemokine combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth...
Articles
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... email c.a.staton@shef.ac.uk 6 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) There are eight different classes of semaphorins, of which five classes...
Articles
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Biochem Soc Trans (2009) 37 (6): 1228–1232.
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
Articles
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
... Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF) Therapeutic angiogenesis involves stimulation of angiogenesis, arteriogenesis and lymphangiogenesis [ 1 ]. Angiogenesis...
Articles
Biochem Soc Trans (2009) 37 (6): 1237–1242.
Published: 19 November 2009
... © 2009 Biochemical Society 2009 carbon monoxide haem oxygenase-1 (HO-1) pre-eclampsia soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is a pregnancy-specific multi-organ syndrome characterized...
Articles
Biochem Soc Trans (2009) 37 (6): 1161–1166.
Published: 19 November 2009
... email shibuya@ims.u-tokyo.ac.jp 28 6 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenic therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1...
Articles
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... to sense a key cytokine in vascular tissues. angiogenesis endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF) The vascular endothelium employs two cell-surface RTKs (receptor tyrosine kinases), VEGFR [VEGF (vascular endothelial growth factor...
Articles
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... growth factor (VEGF) The consequences of these three facts are shown in Figure 2 (B) and are as follows. (i) The short-term stimulation of angiogenesis and arteriogenesis in diabetes mellitus is reduced based on a poor response to VEGF, namely VEGF resistance. This is especially true...
Articles
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... © 2009 Biochemical Society 2009 hypoxia ischaemic disease Notch intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth factor (VEGF) ADAM a disintegrin and metalloproteinase Dll1 Delta-like 1 Flt4 Fms-like tyrosine kinase 4...
Articles
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
... atrium [ 1 ]. angioplasticity asthma endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) © The Authors Journal compilation © 2009 Biochemical Society 2009 17 2 2009 1 Correspondence may be addressed to either author (email...
Articles
Biochem Soc Trans (2008) 36 (5): 946–949.
Published: 19 September 2008
.... Mechanical and metabolic coupling could represent an important mechanism of injury in the diabetic kidney. albuminuria blood pressure diabetes kidney disease proteinuria transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) 1 email luigi.gnudi@kcl.ac.uk 30...
Articles
Biochem Soc Trans (2007) 35 (4): 701–703.
Published: 20 July 2007
... compilation © 2007 Biochemical Society 2007 adiponectin bone metastasis cathepsin K prostate cancer secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone...
Articles
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
... and their receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
Articles
Biochem Soc Trans (2003) 31 (6): 1171–1177.
Published: 01 December 2003
... of Essex, Colchester, 2–4 July 2003 10 June 2003 © 2003 Biochemical Society 2003 angiogenesis Flt1 kinase-insert-domain-containing receptor (KDR) mitogen-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) Abbreviations used: eNOS...