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Keywords: vascular endothelial growth factor (VEGF)
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
... or stability of pre-existing tumour blood vessels. The vascular endothelial growth factor (VEGF) signalling axis remains the most widely studied, with biological and small-molecule therapeutics now registered for clinical use. However, despite these successes, the activity of these agents is not as widespread...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1569–1575.
Published: 17 November 2014
... compilation © 2014 Biochemical Society 2014 angiogenesis bevacizumab endothelial cell (EC) resistance vascular endothelial growth factor (VEGF) Bevacizumab (Avastin®; Genentech/Roche) is a humanized monoclonal antibody that neutralizes all isoforms of VEGF-A with high specificity, thereby...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1576–1583.
Published: 17 November 2014
... cells and, hence, suitable for targeting of the vasculature. Both genetic and drug targeting experiments have demonstrated the requirement for the vascular endothelial growth factor (VEGF) system, the Delta-like–Notch system and the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (6): 1616–1622.
Published: 17 November 2014
... contraction shear stress skeletal muscle stretch vascular endothelial growth factor (VEGF) MMPs induce proteolytic degradation of the extracellular matrix, which is an essential step in sprouting angiogenesis that allows the endothelial sprout to protrude from the existing capillary. Accordingly...
Articles
SRPK1 inhibition in vivo : modulation of VEGF splicing and potential treatment for multiple diseases
Sebastian Oltean, Melissa Gammons, Richard Hulse, Maryam Hamdollah-Zadeh, Athina Mavrou, Lucy Donaldson, Andrew H. Salmon, Steve J. Harper, Michael R. Ladomery, David O. Bates
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 831–835.
Published: 20 July 2012
... macular degeneration N. Engl. J. Med. 2004 351 2805 2816 19 Schrijvers B.F. Flyvbjerg A. De Vriese A.S. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology Kidney Int. 2004 65 2003 2017 20 Marrelli A. Cipriani P. Liakouli V...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 20–25.
Published: 19 January 2012
...-VEGF therapy biomarker neuropilin receptor tyrosine kinase (RTK) vascular endothelial growth factor (VEGF) The mammalian VEGF (vascular endothelial growth factor) family consists of five homodimeric polypeptides of 40 kDa: VEGF-A, -B, -C and -D and PlGF (placental growth factor). VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1649–1653.
Published: 21 November 2011
... chemokine endothelial cell regulated upon activation normal T-cell expressed and secreted (RANTES) vascular endothelial growth factor (VEGF) It was demonstrated that inhibition of expression of a pro-angiogenic factor, VEGF, decreased the progression of atherosclerosis [ 11 ]. Other studies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1644–1648.
Published: 21 November 2011
... sprouting vascular endothelial growth factor (VEGF) VEGF (vascular endothelial growth factor-A) is the master regulator of angiogenesis both in physiological development and in disease [ 1 ] and is capable of starting the complex cascade of events leading to endothelial cell activation, assembly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1576–1582.
Published: 21 November 2011
... to the VEGF (vascular endothelial growth factor) family of proteins and their receptors, in particular sVEGFR1 [soluble VEGFR (VEGF receptor) 1], PlGF (placental growth factor) and VEGF-A [ 8 – 10 ] placental growth factor (PlGF) pre-eclampsia vascular endothelial growth factor (VEGF) VEGFs bind...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1556–1559.
Published: 21 November 2011
... and Edited by Stuart Egginton and Roy Bicknell (Birmingham, U.K.). 8 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 exercise hypoxia hypoxia-inducible factor (HIF) inflammation vascular endothelial growth factor (VEGF) In 1979, Dvorak et al. [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1560–1564.
Published: 21 November 2011
... should be addressed (email a.bikfalvi@angio.u-bordeaux1.fr ). 12 9 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis chemokine combinatorial therapy resistance to anti-angiogenesis therapy stress response vascular endothelial growth factor (VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1565–1570.
Published: 21 November 2011
... email c.a.staton@shef.ac.uk 6 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 angiogenesis class 3 semaphorin neuropilin plexin vascular endothelial growth factor (VEGF) There are eight different classes of semaphorins, of which five classes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1551–1555.
Published: 21 November 2011
... growth factor (VEGF) The plenary lecture was delivered by Peter Wagner [ 1 ] on the critical role of arguably the most well-known and significant player in angiogenesis, VEGF (vascular endothelial growth factor). This emphasizes the need to be aware of the different demands...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1654–1658.
Published: 21 November 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 angiopoietin neuropilin-1 platelet-derived growth factor BB (PDGF-BB) transforming growth factor β (TGFβ) vascular endothelial growth factor (VEGF) vascular maturation Vascular maturation, which involves...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1583–1591.
Published: 21 November 2011
... factor (PDGF) receptor tyrosine kinase vascular endothelial growth factor (VEGF) NRP (neuropilin) 1 and the related molecule NRP2 are receptors for two unrelated types of polypeptide ligand: class 3 semaphorins, a subtype of a large family of secreted polypeptides essential mainly for targeting...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1619–1627.
Published: 21 November 2011
... (sEng) soluble Fms-like tyrosine kinase receptor-1 (sFlt-1) vascular endothelial growth factor (VEGF) Pre-eclampsia is an important cause of maternal and perinatal mortality affecting 5–7% of pregnant women [ 1 ]. Clinically, it is defined as the de novo onset of hypertension (systolic blood...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1184–1188.
Published: 19 November 2009
... pathways to cellular events. 1 To whom correspondence should be addressed (email h.mellor@bristol.ac.uk ). 28 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis intracellular trafficking vascular endothelial growth factor (VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1198–1200.
Published: 19 November 2009
... angiogenesis arteriogenesis gene therapy ischaemia lymphangiogenesis vascular endothelial growth factor (VEGF) References 1 Ylä-Herttuala S. Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth Nat. Med. 2003 9 694 701 2 Alitalo K. Tammela T...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1228–1232.
Published: 19 November 2009
... diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF 165 (VEGF 164 in mice). In vitro , SEMA3A competes with VEGF 164 for binding to NRP1 to modulate the migration of endothelial cells and neuronal progenitors. It was therefore...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1171–1178.
Published: 19 November 2009
... partners. 1 To whom correspondence should be addressed (email i.zachary@ucl.ac.uk ). 25 8 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis cancer neuron semaphorin vascular endothelial growth factor (VEGF) NRP1 (neuropilin-1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1237–1242.
Published: 19 November 2009
... soluble endoglin (sEng) soluble Fms-like tyrosine kinase-1 (sFlt-1) vascular endothelial growth factor (VEGF) The use of antioxidant supplements, as shown by the VIP (Vitamins In Preeclampsia) trial, is insufficient to regulate the oxidative status of the placenta and to prevent pre-eclampsia...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1161–1166.
Published: 19 November 2009
... therapy oedema vascular endothelial growth factor (VEGF) vascular endothelial growth factor E (VEGF-E) vascular endothelial growth factor receptor 1 (VEGFR-1) Blood vessels supply nutrients and oxygen to tissues in the body. Their formation involves two major processes: (i) vasculogenesis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1193–1197.
Published: 19 November 2009
... To whom correspondence should be addressed (email s.ponnambalam@leeds.ac.uk ). 6 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis endocytosis proteolysis receptor tyrosine kinase signalling vascular endothelial growth factor (VEGF...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1167–1170.
Published: 19 November 2009
... basis of VEGF resistance in diabetes mellitus. 1 email j.waltenberger@mumc.nl 7 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 angiogenesis arteriogenesis diabetes mellitus endothelial dysfunction signal transduction vascular endothelial growth...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1221–1227.
Published: 19 November 2009
... and skeletal myocyte regeneration. Further characterization of Notch interaction with other signalling pathways might help identify novel targets for therapeutic angiogenesis. hypoxia ischaemic disease Notch intracellular domain Notch signalling therapeutic angiogenesis vascular endothelial growth...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 805–810.
Published: 22 July 2009
.... Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography ©2009. All Rights Reserved. angioplasticity asthma endothelial progenitor cell (EPC) inflammation lung vascular endothelial growth factor (VEGF) The human lung circulation consists of two blood...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 946–949.
Published: 19 September 2008
... transforming growth factor-β1 (TGF-β1) vascular endothelial growth factor (VEGF) Hypertension is an important contributor to diabetic renal disease, and the interplay between hypertension and renal disease is complex [ 1 , 2 ]: renal impairment contributes to the development and severity...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (4): 701–703.
Published: 20 July 2007
... K prostate cancer secreted protein acidic and rich in cysteine (SPARC) vascular endothelial growth factor (VEGF) Skeletal metastasis is the result of interaction of the tumour cells with the bone microenvironment and requires processes such as proteolytic degradation and osteoclastic bone...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (3): 451–453.
Published: 22 May 2006
... and their receptors, extracellular matrix molecules and enzymes bind to specific sites on the HS sugar chain. For example, HS proteoglycans have profound effects on the bioactivity of the key angiogenic factor VEGF (vascular endothelial growth factor) (VEGF 165 ), affecting its diffusion, half-life and interaction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2003) 31 (6): 1171–1177.
Published: 01 December 2003
...-activated protein kinase (MAPK) survival vascular endothelial growth factor (VEGF) M itogenic and M igratory Signals from G PCRs and Tyrosine Kinases Integration of Mitogenic and Migratory Signals from G-Protein-Coupled Receptors and Tyrosine Kinases Hormone Group Colloquium Edited by T. Palmer...
