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Keywords: variant surface glycoprotein
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Articles

Maintaining the protective variant surface glycoprotein coat of African trypanosomes

G. Rudenko
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 981–982.
DOI: https://doi.org/10.1042/BST0330981
Published: 26 October 2005
...G. Rudenko The African trypanosome Trypanosoma brucei has a precarious existence as an extracellular parasite of the mammalian bloodstream, where it is faced with continuous immune attack. Key to survival is a dense VSG (variant surface glycoprotein) coat, which is repeatedly switched during...
View article titled, Maintaining the protective <span class="search-highlight">variant</span> <span class="search-highlight">surface</span> <span class="search-highlight">glycoprotein</span> coat of African trypanosomes
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Articles

What the genome sequence is revealing about trypanosome antigenic variation

J.D. Barry, L. Marcello, L.J. Morrison, A.F. Read, K. Lythgoe, N. Jones, M. Carrington, G. Blandin, U. Böhme, E. Caler, C. Hertz-Fowler, H. Renauld, N. El-Sayed, M. Berriman
Journal: Biochemical Society Transactions
Biochem Soc Trans (2005) 33 (5): 986–989.
DOI: https://doi.org/10.1042/BST0330986
Published: 26 October 2005
... their VSG (variant surface glycoprotein) coat. Switching proceeds by duplication of silent VSG genes into a transcriptionally active locus. The genome project has revealed that most of the silent archive consists of hundreds of subtelomeric VSG tandem arrays, and that most of these are not functional genes...
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Articles

The N-glycan glucosidase system in Trypanosoma brucei

D. Jones, A. Mehlert, M.A.J. Ferguson
Journal: Biochemical Society Transactions
Biochem Soc Trans (2004) 32 (5): 766–768.
DOI: https://doi.org/10.1042/BST0320766
Published: 26 October 2004
... to characterize three novel N-glycan structures on the variant surface glycoprotein of the null mutant. On the basis of our results, we propose that two N-glycan precursors are available for transfer to variant surface glycoprotein (variant 221) in the ER of T. brucei ; only one of these precursors...
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