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Keywords: vaccines
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Articles
Biochem Soc Trans (2023) 51 (6): 2017–2028.
Published: 30 November 2023
... cancer diagnoses. However, only a minority of patients derive durable benefit and progress with traditional approaches, such as cancer vaccines, remains unsatisfactory. A key to overcoming these barriers resides with a deeper understanding of tumor antigen presentation and the complex and dynamic...
Articles
Biochem Soc Trans (2021) 49 (6): 2627–2638.
Published: 23 November 2021
... such as G protein-coupled receptors (GPCRs), ion channels, and solute carrier (SLCs) proteins. Structural characterization of biologics, such as vaccines, viral vectors, and gene therapy agents, has also become significantly more tractable. As a result, cryo-EM has begun to make major impacts in bringing...
Articles
Biochem Soc Trans (2021) 49 (5): 2411–2429.
Published: 08 September 2021
...Magdalena E. Zasłona; A. Michael Downey; Peter H. Seeberger; Oren Moscovitz The importance of vaccine-induced protection was repeatedly demonstrated over the last three decades and emphasized during the recent COVID-19 pandemic as the safest and most effective way of preventing infectious diseases...
Articles
Biochem Soc Trans (2019) 47 (4): 1131–1141.
Published: 24 July 2019
..., and so would be ideal vaccine candidates, but unstable expression due to phase-variation may allow vaccine escape. This review will summarise our current understanding of phase-variable genes that switch expression by a variety of mechanisms, and describe their role in disease and pathobiology...