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Biochem Soc Trans (2021) 49 (2): 629–644.
Published: 17 March 2021
...Indrajit Sahu; Michael H. Glickman Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S proteasome. Additionally, a disordered segment on the substrate — either intrinsic or induced — is critical for proteasome engagement. The proteasome is geared to interact...
Biochem Soc Trans (2019) 47 (6): 1857–1866.
Published: 17 December 2019
...Thomas Hermanns; Kay Hofmann Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-κB activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles...
Biochem Soc Trans (2019) 47 (6): 1949–1962.
Published: 12 December 2019
...EH Radley; J Long; KC Gough; R Layfield Ubiquitin modifications of target proteins act to localise, direct and specify a diverse range of cellular processes, many of which are biomedically relevant. To allow this diversity, ubiquitin modifications exhibit remarkable complexity, determined...
Biochem Soc Trans (2017) 45 (5): 1137–1148.
Published: 22 September 2017
...Rachel E. Heap; Megan S. Gant; Frederic Lamoliatte; Julien Peltier; Matthias Trost Post-translational control of proteins through covalent attachment of ubiquitin plays important roles in all eukaryotic cell functions. The ubiquitin system in humans consists of 2 E1, 35 E2 and >600 E3 ubiquitin...
Biochem Soc Trans (2017) 45 (5): 1125–1136.
Published: 12 September 2017
... 100 deubiquitylase enzymes (DUBs) are assigned to six subfamilies and many of these DUBs can remove ubiquitin from proteins to reverse signals. Roles for individual DUBs have been delineated within specific cellular processes, including many that are dysregulated in diseases, particularly cancer...
Biochem Soc Trans (2016) 44 (3): 796–801.
Published: 09 June 2016
...-associated athanogene 6 (BAG6), which appear to play a decisive role in enforcing quality control over hydrophobic precursor proteins that have mislocalized to the cytosol, directing them to either productive membrane insertion or selective ubiquitination and proteasomal degradation. 1 To whom...