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Keywords: ubiquitin proteasome system
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Articles
Biochem Soc Trans (2024) 52 (2): 627–637.
Published: 04 April 2024
... 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 di-Gly peptides mass spectrometry proteomics ubiquitin landscape ubiquitin proteasome system Ubiquitination is a post-translational modification (PTM), defined as a covalent attachment...
Articles
Biochem Soc Trans (2021) 49 (2): 629–644.
Published: 17 March 2021
... Attribution License 4.0 (CC BY) . functional characterization molecular ultrastructure proteasomes ubiquitin proteasome system ubiquitin signalling ubiquitins Proteasomes are large protein complexes that carry out regulated intracellular proteolysis. All eukaryotic cells use proteasomes...
Articles
Biochem Soc Trans (2021) 49 (1): 365–377.
Published: 26 February 2021
... and defective proteins from the cell. The ubiquitin-proteasome system is a key pathway for the molecular control of misfolded cytosolic proteins, co-opting a cascade of ubiquitin ligases to direct terminally damaged proteins to the proteasome via modification with chains of the small protein, ubiquitin. Despite...
Articles
Biochem Soc Trans (2021) 49 (1): 519–529.
Published: 05 February 2021
...Yang Cao; Hang Zhou; Xiaoyu Chen; Yin Li; Junwen Hu; Guoyang Zhou; Lin Wang The ubiquitin proteasome system (UPS) serves as the major posttranslational modification system for the maintenance of protein homeostasis. The ubiquitin ligases (E3s) are responsible for the recognition and recruitment...
Articles
Biochem Soc Trans (2020) 48 (4): 1557–1567.
Published: 06 July 2020
...Richard T. Timms; Itay Koren Selective protein degradation by the ubiquitin-proteasome system (UPS) is thought to be governed primarily by the recognition of specific motifs — degrons — present in substrate proteins. The ends of proteins — the N- and C-termini – have unique properties...
Articles
Biochem Soc Trans (2019) 47 (6): 1867–1879.
Published: 17 December 2019
...) degradation [ 6 ]. In addition to highlighting findings on these major fields of USP8 research, we will discuss additional functions of USP8 that have emerged in recent years. Cushings disease DUBs isopeptidase ubiquitin proteasome system UBPy USP8 © 2019 The Author(s) 2019...