...Hesso Farhan Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. While most attention has been devoted to tyrosine kinases signaling at the plasma membrane and the cytosol, very...

... cancer growth factor microRNA (miRNA) network tyrosine kinase The advancement of high-throughput genomic screens, along with the development of software able to predict targets of miRNAs, will eventually yield high granularity maps combining signal transduction pathways, transcriptional...

...), but as a result of genomic instability, it progresses over time to accelerated phase and then to BC (blast crisis), becoming increasingly resistant to therapy. bcr-abl is a constitutively active tyrosine kinase that has been targeted by TKIs (tyrosine kinase inhibitors), including IM (imatinib mesylate...

... of tyrosine phosphatases resulted in a negative shift in the voltage dependence of inactivation. Thus the effects of this phosphatase counteract those of tyrosine kinases on the rat brain sodium channel. Regulation of sodium channels by serine/threonine and tyrosine kinases provides a potent means...

... phosphatidylinositol 3-kinase RAFTs T lymphocytes tyrosine kinase PH, pleckstrin homology PI-3K, phosphoinositide-3 kinase SH, Src homology, TCR, T-cell receptor 5 6 7 8 9 10 I I I2 Adams. J. A,, McGlone. M. L.. Gibson, R and Taylor, 5. S. ( 1995) Biochemistry 34, 2447-2454 Yonemoto. W.. McGlone. M. L...

...-mail ks14@mole.bio.cam.ac.uk ) 12 4 2001 © 2001 Biochemical Society 2001 chimaeric receptors domain structure glucose transport hybrid receptors tyrosine kinase IR, insulin receptor IGF, insulin-like growth factor IGFR, type I IGF receptor TK, tyrosine kinase IRR, IR-related...