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Keywords: type 2 diabetes
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Articles
Biochem Soc Trans (2023) 51 (1): 287–301.
Published: 06 January 2023
... by Portland Press Limited on behalf of the Biochemical Society 2023 bioenergetics central nervous system insulin resistance metabolism neuromodulation type 2 diabetes Insulin is a peptide best known by being produced by β-cells of the pancreatic islets in response to elevated blood glucose...
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Biochem Soc Trans (2019) 47 (2): 571–590.
Published: 01 April 2019
...@anu.edu.au ) 23 11 2018 24 2 2019 25 2 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 amino acid metabolism amino acid transporters fibroblast growth factor 21 insulin secretion insulin signalling type 2 diabetes...
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Biochem Soc Trans (2016) 44 (2): 638–644.
Published: 11 April 2016
... of LC and direct infusion forms of MS it is now possible to profile the individual TAGs in blood plasma or tissue extracts. This mini review surveys the information that is obtainable from the lipidomic profiling of TAGs in following metabolic diseases such as type 2 diabetes (T2DM), cardiovascular...
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Biochem Soc Trans (2015) 43 (5): 1108–1111.
Published: 09 October 2015
...Sabrina Prudente; Vincenzo Trischitta Insulin resistance is pathogenic for many prevalent disorders including type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), polycystic ovary syndrome, non-alcoholic fatty liver disease, Alzheimer's and Parkinson's diseases and several cancers...
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Biochem Soc Trans (2011) 39 (1): 1–13.
Published: 19 January 2011
... eukaryotes, it is critically involved in the responses to starvation for a carbon source. Because of its ability to switch cellular metabolism from anabolic to catabolic mode, AMPK has become a key drug target to combat metabolic disorders associated with overnutrition such as Type 2 diabetes, and some...
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Biochem Soc Trans (2010) 38 (6): 1565–1570.
Published: 24 November 2010
...David Ferland-McCollough; Susan E. Ozanne; Kenneth Siddle; Anne E. Willis; Martin Bushell T2D (Type 2 diabetes mellitus) is a major health issue that has reached epidemic status worldwide. T2D is a progressive metabolic disorder characterized by reduced insulin sensitivity, insulin resistance...
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Biochem Soc Trans (2008) 36 (5): 905–908.
Published: 19 September 2008
... of Type 2 diabetes in humans. However, when incubated in vitro , β-cells respond differentially to long-chain saturated and mono-unsaturated fatty acids, suggesting that these molecules may regulate cell functionality by different mechanisms. In particular, it is clear that, whereas saturated fatty acids...
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Biochem Soc Trans (2008) 36 (5): 916–919.
Published: 19 September 2008
..., as well as regulation of secretion in response to glucose and muscarinic receptor agonists. Recently, the nPKC isoform, PKCϵ, has also been implicated in the loss of insulin secretory responsiveness that underpins the development of Type 2 diabetes. 1 To whom correspondence should be addressed...
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Biochem Soc Trans (2008) 36 (3): 306–311.
Published: 21 May 2008
... study of the mutational mechanisms for a number of these has provided important insights into glucokinase regulation. Increased understanding of post-translational regulatory mechanisms holds the promise of novel pharmacotherapeutic options for the treatment of T2DM (Type 2 diabetes mellitus...
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Biochem Soc Trans (2007) 35 (4): 713–716.
Published: 20 July 2007
...) glucagon-like peptide receptor 1 (GLP1-R) G-protein-coupled receptor (GPCR) peptide binding Type 2 diabetes In order to better understand how GLP-1 [glucagon-like peptide-1-(7–36)-amide] and its analogues bind and activate the GLP-1R (GLP-1 receptor), our group have spent several years...
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Biochem Soc Trans (2007) 35 (1): 33–36.
Published: 22 January 2007
..., multigenic forms of the disease. Ultimately, this is a potential route to treatment of both disease types. This approach is discussed in relation to Type 2 diabetes, arising from both insufficient insulin production and insulin resistance. 1 email so104@medschl.cam.ac.uk 31 8 2006 ©...
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Biochem Soc Trans (2006) 34 (5): 802–805.
Published: 25 October 2006
.... These results support a role for UCP2 as a gene contributing to the pathogenesis of Type 2 diabetes. Working from the premise that increased UCP2 expression or activity (alone, or in concert with other regulators) in diabetes can suppress insulin secretion sufficiently to cause hyperglycaemia, then strategies...
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Biochem Soc Trans (2006) 34 (5): 806–810.
Published: 25 October 2006
... are impaired. β-cell glucose metabolism nicotinamide nucleotide transhydrogenase (Nnt) oxidative stress reactive oxygen species Type 2 diabetes © 2006 The Biochemical Society 2006 1 To whom correspondence should be addressed (email frances.ashcroft@physiol.ox.ac.uk ). 24 7 2006...
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Biochem Soc Trans (2006) 34 (5): 779–782.
Published: 25 October 2006
... The Biochemical Society 2006 birth weight developmental programming epigenetic modification fetal growth maternal nutrition Type 2 diabetes Although fetal growth and development are driven by the programme encoded in its genome, the genetic regulation of fetal growth is influenced by the intra...