1-15 of 15
Keywords: tumour suppressor
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem Soc Trans (2017) 45 (3): 845–854.
Published: 15 June 2017
... downstream signalling and tumorigenesis. Since the E ndosomal S orting C omplexes R equired for T ransport (ESCRT) controls these processes, ESCRT components were proposed to act as tumour suppressor genes. However, the bona fide role of ESCRT components in tumorigenesis has not been clearly demonstrated...
Articles
Biochem Soc Trans (2016) 44 (3): 925–931.
Published: 09 June 2016
..., and the impact on the pathways in which that protein is involved. In this paper we examine the mutation patterns observed in oncogenes and tumour suppressors, and discuss different approaches that have been developed to identify driver mutations within cancers that contribute to the disease progress. We also...
Includes: Supplementary data
Articles
Biochem Soc Trans (2012) 40 (4): 826–830.
Published: 20 July 2012
... function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer. 1 To whom correspondence should be addressed...
Articles
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... development. We have recently described a novel regulatory pathway involving miR-29 and p53 tumour suppressor which has provided valuable information on the molecular components orchestrating the response to nuclear damage stress. Furthermore, by using progeroid mice deficient in ZMPSTE24 (zinc...
Articles
Biochem Soc Trans (2009) 37 (1): 137–142.
Published: 20 January 2009
.... 1 To whom correspondence should be addressed (email stenmark@ulrik.uio.no ). 17 7 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 apoptosis endosomal sorting complex required for transport (ESCRT) growth factor receptor Notch tumour suppressor...
Articles
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
...Lezanne Ooi; Ian C. Wood Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult...
Articles
Biochem Soc Trans (2008) 36 (3): 472–478.
Published: 21 May 2008
...Michelle J. Nyhan; Gerald C. O'Sullivan; Sharon L. McKenna The VHL (von Hippel–Lindau) tumour-suppressor gene is inactivated in VHL disease and in sporadic cases of CCRCC [clear-cell RCC (renal cell carcinoma)]. pVHL (VHL protein) functions as part of an E3 ubiquitin ligase complex that targets...
Articles
Biochem Soc Trans (2008) 36 (3): 464–468.
Published: 21 May 2008
...Joanne Elliott; Michelle B. Hookham; James A. Johnston Many studies have suggested that E3 ubiquitin ligases can behave as either oncogenes or tumour suppressor genes and, recently, it has become clear that the SOCS (suppressor of cytokine signalling) E3 ligases fit this mould. While most cancer...
Articles
Biochem Soc Trans (2007) 35 (6): 1574–1578.
Published: 23 November 2007
... a stabilized tetramer of the oligomerization domain of the human p53 tumour-suppressor protein by tandem dimerization. 1 email gpoon@uhnres.utoronto.ca . 22 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 covalent linkage oligomeric stability...
Articles
Biochem Soc Trans (2006) 34 (5): 633–645.
Published: 25 October 2006
... directions in this field. 1 email simon.boulton@cancer.org.uk 6 6 2006 © 2006 The Biochemical Society 2006 BRCA1 BRCA2 DNA repair DNA-damage sensing tumour suppressor One of the complicating issues with defining the cellular function of BRCA1 is that its loss in cells...
Articles
Biochem Soc Trans (2006) 34 (5): 746–748.
Published: 25 October 2006
...-dependent transcription of DNA synthesis genes. Additionally, gankyrin, by binding to Mdm2, increases the ubiquitylation and degradation of p53 and prevents apoptosis. Gankyrin controls the functions of two major tumour suppressors and, when overexpressed, causes hepatocellular carcinoma. 1 To whom...
Articles
Biochem Soc Trans (2005) 33 (4): 730–732.
Published: 01 August 2005
...C. Robbe; C. Paraskeva; J. Mollenhauer; J.C. Michalski; C. Sergi; A. Corfield The gene DMBT1 (deleted in malignant brain tumour-1) has been proposed to play a role in brain and epithelial cancer, but shows unusual features for a classical tumour-suppressor gene. On the one hand, DMBT1 has been...
Articles
Biochem Soc Trans (2005) 33 (1): 237–240.
Published: 01 February 2005
...V. Ganapathy; E. Gopal; S. Miyauchi; P.D. Prasad SLC5A8 is a candidate tumour suppressor gene that is silenced in colon cancer, gastric cancer and possibly other cancers in humans. This gene codes for a transporter belonging to the Na + /glucose co-transporter gene family ( SLC5 ). The cancer...
Articles
Biochem Soc Trans (2004) 32 (6): 1107–1109.
Published: 26 October 2004
... -Sponsored Research Colloquium. 1 7 2004 © 2004 The Biochemical Society 2004 actin cytoskeleton focal adhesion phospholipase C RhoGAP tumour suppressor vinculin p122RhoGAP (p122) (where GAP stands for GTPase-activating protein) is a dual functional molecule. It was cloned...
Articles
Biochem Soc Trans (2004) 32 (2): 343–347.
Published: 01 April 2004
...T. Maehama; F. Okahara; Y. Kanaho The tumour suppressor PTEN (phosphatase and tensin homologue deleted on chromosome 10) plays essential roles in regulating signalling pathways involved in cell growth and apoptosis, and is inactivated in a wide variety of tumours. The role of PTEN as a tumour...