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Keywords: tumour
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Articles
Biochem Soc Trans (2015) 43 (3): 328–332.
Published: 01 June 2015
... protein synthesis synaptic plasticity tumour Eukaryotic elongation factor 2 kinase (eEF2K) is an atypical calcium/calmodulin (Ca/CaM)-dependent protein kinase which phosphorylates and inactivates eEF2 [ 1 ]. eEF2 is required for the movement of ribosomes along mRNAs during translation elongation...
Articles
Biochem Soc Trans (2014) 42 (6): 1601–1607.
Published: 17 November 2014
...Neil R. Smith; Stephen R. Wedge; Aurelien Pommier; Simon T. Barry There has been significant investment in developing novel therapies to target solid tumour vasculature. Different technical approaches have been utilized with the aim of inhibiting tumour angiogenesis or compromising the function...
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Biochem Soc Trans (2014) 42 (6): 1647–1652.
Published: 17 November 2014
... of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment. VEGF is the most prominent pro-angiogenic factor and is a crucial regulator of developmental blood...
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Biochem Soc Trans (2014) 42 (6): 1590–1595.
Published: 17 November 2014
... affects tumour angiogenesis and cancer progression. Revisiting the fundamental biology behind how this integrin regulates tumour growth and angiogenesis, we believe, is the key not only to understanding how angiogenesis is normally co-ordinated, but also in success with drugs directed against it. 2...
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Biochem Soc Trans (2014) 42 (6): 1563–1568.
Published: 17 November 2014
...Thaned Kangsamaksin; Ian W. Tattersall; Jan Kitajewski The Notch signalling pathway is a key regulator of developmental and tumour angiogenesis. Inhibition of Delta-like 4 (Dll4)-mediated Notch signalling results in hyper-sprouting, demonstrating that Notch regulates tip-stalk cell identity...
Articles
Biochem Soc Trans (2014) 42 (2): 500–503.
Published: 20 March 2014
... copy number increase in the human population appears to be approximately 2% and may be linked to a risk of obesity, diabetes and aging. Increased GLO1 copy number has been found in human tumour cell lines and primary human tumours. The minimum common copy number increase region was approximately 1 Mb...
Articles
Biochem Soc Trans (2013) 41 (2): 664–669.
Published: 21 March 2013
... ). 14 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 blastocyst embryo glycolysis pyruvate kinase M2 tumour The idea that glycolysis increases in cancers and embryos solely to provide ATP may be misguided since glycolytic conversion of glucose...
Articles
Biochem Soc Trans (2013) 41 (1): 268–272.
Published: 29 January 2013
...Monika Baj-Krzyworzeka; Jarosław Baran; Rafał Szatanek; Bożenna Mytar; Maciej Siedlar; Marek Zembala The tumour microenvironment represents a dynamic complex milieu, which includes tumour cells, cells of the immune system and other (cellular and non-cellular) components. The role...
Articles
Biochem Soc Trans (2012) 40 (4): 821–825.
Published: 20 July 2012
... of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance. 1 email r.m.drayton@sheffield.ac.uk 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cisplatin microRNA (miRNA) protein expression tumour...
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Articles
Biochem Soc Trans (2011) 39 (1): 378–382.
Published: 19 January 2011
...-glycosylation and tumorigenesis, as changes in tumour environment and cell adhesion are hallmarks of cancer progression. 1 To whom correspondence should be addressed (email Kelly.Tenhagen@nih.gov ). 31 8 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer...
Articles
Biochem Soc Trans (2008) 36 (4): 708–711.
Published: 22 July 2008
... in determining the level of ERβ protein expression. We have also shown that these alternative ERβ 5′-UTRs have a tissue-specific distribution and are differentially expressed between various normal and tumour tissues. Our results also suggest that alternative 5′-UTRs can influence downstream splicing events...
Articles
Biochem Soc Trans (2007) 35 (5): 1018–1020.
Published: 25 October 2007
... various tumour conditions in mice. As predicted, we were able to identify various PKC isoforms to be either up- or down-regulated during the development and progression of certain tumours, implying that these isoforms are substantially linked to the biology of these tumours. In order to prove...
Articles
Biochem Soc Trans (2007) 35 (5): 1377–1378.
Published: 25 October 2007
...W.-B. Wu; H.-S. Chiang; J.-Y. Fang; C.-F. Hung Tumours are complex tissues composed of both matrix proteins and stromal cells such as fibroblasts and inflammatory cells. Tumour progression is often the result of dynamic interactions between the tumour cells and their surroundings. Lycopene...
Articles
Biochem Soc Trans (2007) 35 (4): 816–820.
Published: 20 July 2007
... transactivator of transcription (Tat) tumour Over the last decade, CPPs, including Tatp (transactivator of transcription peptide) and various oligoarginines, have been widely exploited for the intracellular delivery of differently sized cargo in a range of cell types, both in vitro and in vivo...
Articles
Biochem Soc Trans (2007) 35 (2): 340–342.
Published: 20 March 2007
... or tumour growth. Since the intestine has the highest metabolic activity of all the internal organs, a tumour will initially compete with the gut for nutrients and energy-providing molecules. The polyamines represent a class of molecules where the demand in the body increases during tumour growth. A tumour...
Articles
Biochem Soc Trans (2006) 34 (5): 722–726.
Published: 25 October 2006
... resistance. 1 To whom correspondence should be addressed (email eric.lam@imperial.ac.uk ). 30 6 2006 © 2006 The Biochemical Society 2006 cell fate forkhead box O (FOXO) phosphoinositide 3-kinase (PI3K) phosphorylation tumour Bcl-6 B-cell lymphocytic-leukaemia proto...
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Biochem Soc Trans (2005) 33 (6): 1531–1533.
Published: 26 October 2005
... correspondence should be addressed (email dominique.bonnet@cancer.org.uk ). 17 6 2005 © 2005 The Biochemical Society 2005 cancer stem cell (CSC) haematopoietic stem cell (HSC) leukaemic stem cell (LSC) self-renewal tumour xenotransplantation model The hallmark properties of HSCs...
Articles
Biochem Soc Trans (2004) 32 (6): 916–917.
Published: 26 October 2004
...J.M. Teodoridis; G. Strathdee; J.A. Plumb; R. Brown Aberrant methylation of CpG islands (CpG-rich regions of DNA associated with the promoters of many genes) is associated with transcriptional inactivation of genes involved in tumour development. Genes involved in key DNA damage response pathways...
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Biochem Soc Trans (2002) 30 (2): 201–207.
Published: 01 April 2002
... Xa and thrombin. These proteases act via protease-activated receptors and tissue factor to alter gene expression, thereby modulating tumour cell growth, invasion, metastasis and angiogenesis. 1 To whom correspondence should be addressed (e-mail mtsampson_uk@hotmail.com ). 26 11 2001...
Articles
Biochem Soc Trans (2002) 30 (2): 173–177.
Published: 01 April 2002
...M. E. Maragoudakis; N. E. Tsopanoglou; P. Andriopoulou Clinical, laboratory, histopathological and pharmacological evidence support the notion that a systemic activation of blood coagulation is often present in cancer patients. Additionally, thrombin was shown to promote tumour progression...