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Biochem Soc Trans (2022) 50 (1): 83–93.
Published: 22 February 2022
... Press Limited on behalf of the Biochemical Society 2022 cell cycle reguation chromatin chromosome condensation tumorigenesis RCC1 (regulator of chromosome condensation 1), a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor (GEF) of Ran...
Biochem Soc Trans (2020) 48 (4): 1609–1621.
Published: 14 August 2020
... to cells, allowing for a selection process to occur and leading to tumorigenesis even in the case of reversible or unstable epigenetic states. This review seeks to highlight how the fundamental epigenetic shifts in cancer contribute to tumorigenesis, and how understanding an integrated view of cancer...
Biochem Soc Trans (2008) 36 (3): 464–468.
Published: 21 May 2008
... overexpression promotes aneuploidy and tumorigenesis in mice Cancer Cell 2007 11 9 23 31 Zheng L. Lee W.H. Retinoblastoma tumor suppressor and genome stability Adv. Cancer Res. 2002 85 13 50 32 Mazoyer S. Genomic rearrangements in the BRCA1 and BRCA2 genes Hum. Mutat...
Biochem Soc Trans (2007) 35 (5): 1352–1354.
Published: 25 October 2007
...E. Petermann; T. Helleday DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often...
Biochem Soc Trans (2005) 33 (6): 1537–1540.
Published: 26 October 2005
... repressor. Previous work has demonstrated that decreased CpG island methylation in mice lacking the DNA methyltransferase DNMT1 is associated with impaired tumorigenesis when crossed on the tumour-susceptible Apc Min/+ background. Mbd2 deficiency also dramatically reduces adenoma burden and extends life...