... reguation chromatin chromosome condensation tumorigenesis Figure 3. The relative expression level of RCC1 . With the exception of acute myeloid leukemia (LAML), testicular germ cell tumor (TGCT), and PCPG (pheochromocytoma and paraganglioma), the expression of RCC1 in tumors is increased...

... to cells, allowing for a selection process to occur and leading to tumorigenesis even in the case of reversible or unstable epigenetic states. This review seeks to highlight how the fundamental epigenetic shifts in cancer contribute to tumorigenesis, and how understanding an integrated view of cancer...

.... Hernando E. Diaz-Rodriguez E. Teruya-Feldstein J. Cordon-Cardo C. Lowe S.W. Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice Cancer Cell 2007 11 9 23 31 Zheng L. Lee W.H. Retinoblastoma tumor suppressor and genome stability Adv...

...E. Petermann; T. Helleday DNA lesions resulting from impaired progression of replication forks are implicated in genetic instability and tumorigenesis. Because the cellular response to these lesions poses an important tumorigenesis barrier, the responsible signalling and repair pathways are often...

... repressor. Previous work has demonstrated that decreased CpG island methylation in mice lacking the DNA methyltransferase DNMT1 is associated with impaired tumorigenesis when crossed on the tumour-susceptible Apc Min/+ background. Mbd2 deficiency also dramatically reduces adenoma burden and extends life...