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Biochem Soc Trans (2020) 48 (4): 1463–1472.
Published: 14 July 2020
...Jani R. Bolla The unique architecture of the mycobacterial cell envelope plays an important role in Mycobacterium tuberculosis ( Mtb ) pathogenesis. A critical protein in cell envelope biogenesis in mycobacteria, required for transport of precursors, trehalose monomycolates (TMMs...
Biochem Soc Trans (2020) 48 (2): 693–707.
Published: 20 April 2020
... ) or Davide M. Ferraris ( firstname.lastname@example.org ) 16 12 2019 10 3 2020 16 3 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cancer drug discovery and design malaria NAD biology NAD dehydrogenases tuberculosis...
Biochem Soc Trans (2012) 40 (3): 573–579.
Published: 22 May 2012
...Sean A. Hudson; Kirsty J. McLean; Andrew W. Munro; Chris Abell TB (tuberculosis) disease remains responsible for the death of over 1.5 million people each year. The alarming emergence of drug-resistant TB has sparked a critical need for new front-line TB drugs with a novel mode of action...
Biochem Soc Trans (2012) 40 (3): 587–593.
Published: 22 May 2012
... P450s also have important roles that impinge directly on human cholesterol synthesis and oxidation. Recent data reveal that Mycobacterium tuberculosis (which infects more than one-third of the world's human population) uses P450s to initiate breakdown of host cholesterol as an energy source. Microbial...
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
...Dany J.V. Beste; Johnjoe McFadden Despite decades of research, many aspects of the biology of Mycobacterium tuberculosis remain unclear, and this is reflected in the antiquated tools available to treat and prevent tuberculosis and consequently this disease remains a serious public health problem...
Biochem Soc Trans (2009) 37 (2): 419–423.
Published: 20 March 2009
... ] for which sensitive assays have been developed for a number of infectious diseases prevalent in the developing world [ 10 – 15 ]. Thus developments of such a platform could significantly improve disease diagnosis for a number of diseases at once. The current LAMP approach to M. tuberculosis DNA detection...
Biochem Soc Trans (2007) 35 (5): 1317–1320.
Published: 25 October 2007
...S.H. Gillespie Tuberculosis remains a global public health threat: the causative organism, Mycobacterium tuberculosis , was once thought to show little genetic variation, but research in the last 10 years has demonstrated an ability to change in a series of different time frames. Related species...
Biochem Soc Trans (2005) 33 (4): 785–791.
Published: 01 August 2005
... tuberculosis and Helicobacter pylori . The pathway is also essential in the malaria vector Plasmodium falciparum . During the last few years, the genes, enzymes, intermediates and mechanisms of the biosynthetic route have been elucidated by a combination of comparative genomics, enzymology, advanced NMR...
Biochem Soc Trans (2004) 32 (4): 626–628.
Published: 01 August 2004
...C.A.L.S. Colaco; C.R. Bailey; J. Keeble; K.B. Walker The need for an effective TB (tuberculosis) vaccine remains acute, with tuberculosis still one of the major killers worldwide and 3 million new infections annually. We report here on the immune responses elicited by HspCs (heat-shock protein...
Biochem Soc Trans (2004) 32 (3): 496–498.
Published: 01 June 2004
...I.P. Fairbairn Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis . A greater understanding of these observations will lead to new...
A.W. Munro, K.J. McLean, K.R. Marshall, A.J. Warman, G. Lewis, O. Roitel, M.J. Sutcliffe, C.A. Kemp, S. Modi, N.S. Scrutton, D. Leys
Biochem Soc Trans (2003) 31 (3): 625–630.
Published: 01 June 2003
...A.W. Munro; K.J. McLean; K.R. Marshall; A.J. Warman; G. Lewis; O. Roitel; M.J. Sutcliffe; C.A. Kemp; S. Modi; N.S. Scrutton; D. Leys Novel drug strategies are desperately needed to combat the global threat posed by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb). The genome sequence...