... in trypanosomes, including expression of the PAD (proteins associated with differentiation) surface proteins and transcriptional down-regulation of the VSG (variant surface glycoprotein) gene. TOR4 kinase forms a structurally and functionally distinct complex named TORC4. TOR4 associates with LST8 (lethal...

...Christine Clayton; Angela Schwede; Mhairi Stewart; Ana Robles; Corinna Benz; June Po; Martin Wurst; Rafael Quieroz; Stuart Archer Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both...

... in all plant and other trypanosome CYP51s, dramatically increases the ability of the enzyme to metabolize O , converting it into a more plant-like sterol 14α-demethylase. A more than 100-fold increase in binding and turnover is observed for the 24-desmethyl analogue of O [ N (norlanosterol)], which...

...P.T. Englund; E.E.C. Agbo; M.E. Lindsay; B. Liu; Y. Liu; S.A. Motyka; G. Yildirir; Z. Zhao African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has...

...J.D. Barry; L. Marcello; L.J. Morrison; A.F. Read; K. Lythgoe; N. Jones; M. Carrington; G. Blandin; U. Böhme; E. Caler; C. Hertz-Fowler; H. Renauld; N. El-Sayed; M. Berriman African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding...

... of this complex is not dependent on Arl1 [ 38 ]. © 2005 The Biochemical Society 2005 Arf Arl1 Golgi GRIP domain GTPase trypanosome The Arf family of GTPases was originally described as a cytosolic cofactor activity required for cholera toxin to ADP-ribosylate the α-subunit of the G s...

...-translational modification trypanosome c -type cytochromes are widespread proteins characterized by covalent attachment of haem to the polypeptide through thioether bonds formed between the vinyl groups of the haem and the thiols of, normally, two cysteine residues in a CXXCH motif. The histidine...

...E. Hendriks; F. J. van Deursen; J. Wilson; M. Sarkar; M. Timms; K. R. Matthews Differentiation between bloodstream and tsetse midgut procyclic forms during the life cycle of the African trypanosome is an attractive model for the analysis of stage-regulated events. In particular, this transformation...