... in trypanosomes, including expression of the PAD (proteins associated with differentiation) surface proteins and transcriptional down-regulation of the VSG (variant surface glycoprotein) gene. TOR4 kinase forms a structurally and functionally distinct complex named TORC4. TOR4 associates with LST8 (lethal...

...Christine Clayton; Angela Schwede; Mhairi Stewart; Ana Robles; Corinna Benz; June Po; Martin Wurst; Rafael Quieroz; Stuart Archer Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both...

... in all plant and other trypanosome CYP51s, dramatically increases the ability of the enzyme to metabolize O , converting it into a more plant-like sterol 14α-demethylase. A more than 100-fold increase in binding and turnover is observed for the 24-desmethyl analogue of O [ N (norlanosterol)], which...

...P.T. Englund; E.E.C. Agbo; M.E. Lindsay; B. Liu; Y. Liu; S.A. Motyka; G. Yildirir; Z. Zhao African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has...

...J.D. Barry; L. Marcello; L.J. Morrison; A.F. Read; K. Lythgoe; N. Jones; M. Carrington; G. Blandin; U. Böhme; E. Caler; C. Hertz-Fowler; H. Renauld; N. El-Sayed; M. Berriman African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding...

... such as Trypanosomes and Dictyostelium . There appear to be a few exceptions including the primitive protozoa Giardia and, perhaps surprisingly, the fission yeast Schizosaccharomyces pombe . Nonetheless, Arl1 is one of the best-conserved Arls, presumably reflecting a fundamental role in eukaryotic cells [ 4 , 11...

... 2005 chloroplast c -type cytochrome haem post-translational modification trypanosome c -type cytochromes are widespread proteins characterized by covalent attachment of haem to the polypeptide through thioether bonds formed between the vinyl groups of the haem and the thiols...

...E. Hendriks; F. J. van Deursen; J. Wilson; M. Sarkar; M. Timms; K. R. Matthews Differentiation between bloodstream and tsetse midgut procyclic forms during the life cycle of the African trypanosome is an attractive model for the analysis of stage-regulated events. In particular, this transformation...