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Keywords: trypanosome
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Articles
Biochem Soc Trans (2013) 41 (4): 934–938.
Published: 18 July 2013
... in trypanosomes, including expression of the PAD (proteins associated with differentiation) surface proteins and transcriptional down-regulation of the VSG (variant surface glycoprotein) gene. TOR4 kinase forms a structurally and functionally distinct complex named TORC4. TOR4 associates with LST8 (lethal...
Articles
Biochem Soc Trans (2008) 36 (3): 520–521.
Published: 21 May 2008
...Christine Clayton; Angela Schwede; Mhairi Stewart; Ana Robles; Corinna Benz; June Po; Martin Wurst; Rafael Quieroz; Stuart Archer Control of gene expression in trypanosomes relies almost exclusively on post-transcriptional mechanisms. Trypanosomes have the normal enzymes for mRNA decay: both...
Articles
Biochem Soc Trans (2006) 34 (6): 1161–1164.
Published: 25 October 2006
... in all plant and other trypanosome CYP51s, dramatically increases the ability of the enzyme to metabolize O , converting it into a more plant-like sterol 14α-demethylase. A more than 100-fold increase in binding and turnover is observed for the 24-desmethyl analogue of O [ N (norlanosterol)], which...
Articles
Biochem Soc Trans (2005) 33 (6): 1409–1412.
Published: 26 October 2005
...P.T. Englund; E.E.C. Agbo; M.E. Lindsay; B. Liu; Y. Liu; S.A. Motyka; G. Yildirir; Z. Zhao African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has...
Articles
Biochem Soc Trans (2005) 33 (5): 986–989.
Published: 26 October 2005
...J.D. Barry; L. Marcello; L.J. Morrison; A.F. Read; K. Lythgoe; N. Jones; M. Carrington; G. Blandin; U. Böhme; E. Caler; C. Hertz-Fowler; H. Renauld; N. El-Sayed; M. Berriman African trypanosomes evade humoral immunity through antigenic variation, whereby they switch expression of the gene encoding...
Articles
Biochem Soc Trans (2005) 33 (4): 601–605.
Published: 01 August 2005
... 1 email sean@mrc-lmb.cam.ac.uk 20 4 2005 Arf Arl1 Golgi GRIP domain GTPase trypanosome The Arf family of GTPases was originally described as a cytosolic cofactor activity required for cholera toxin to ADP-ribosylate the α-subunit of the G s heterotrimeric G-protein...
Articles
Biochem Soc Trans (2005) 33 (1): 145–146.
Published: 01 February 2005
... trypanosome c -type cytochromes are widespread proteins characterized by covalent attachment of haem to the polypeptide through thioether bonds formed between the vinyl groups of the haem and the thiols of, normally, two cysteine residues in a CXXCH motif. The histidine is an axial ligand to the haem...
Articles
Biochem Soc Trans (2000) 28 (5): 531–536.
Published: 01 October 2000
...E. Hendriks; F. J. van Deursen; J. Wilson; M. Sarkar; M. Timms; K. R. Matthews Differentiation between bloodstream and tsetse midgut procyclic forms during the life cycle of the African trypanosome is an attractive model for the analysis of stage-regulated events. In particular, this transformation...