...R. Schindl; C. Romanin The large family of mammalian TRP (transient receptor potential) ion channels encompasses diverse sensory functions. TRP proteins consist of six transmembrane domains, with a pore–loop motif between the fifth and sixth domains and cytosolic N- and C-termini. The intracellular...

... that the channel lining domain of such receptors is formed by the α-helical M2 domain (second transmembrane domain) contributed by each of five subunits present within the receptor complex. Specific amino acid residues within the M2 domain have accordingly been demonstrated to influence both single-channel...

..., the two proteins associated into homodimers and homotrimers respectively. Moreover, studies using the TOXCAT assay system confirmed that the αIIb and β3 transmembrane domains can self-associate in biological cell membranes. Transmembrane domain-mediated homo-oligomerization provides a plausible structural...

... reticulum membrane protein insertion protein targeting protein translocation Sec61 translocon transmembrane domain Abbreviations used: MOM, mitochondrial outer membrane; ER, endoplasmic reticulum; SNARE, soluble N -ethylmaleimide-sensitive factor attachment protein receptor; TA, C-tail...

... correspondence should be addressed (e-mail Stephen.High@man.ac.uk ). 9 June 2003 © 2003 Biochemical Society 2003 assembly endoplasmic reticulum translocon (ER translocon) integration transmembrane domain Abbreviations used: BiP, immunoglobulin-binding protein; ER, endoplasmic...

.... endoplasmic reticulum glycosylphosphatidylinositol-anchor addition (GPI-anchor addition) protein translocation signal sequence stop transfer sequence transmembrane domain Abbreviations used: GPI, glycosylphosphatidylinositol; ER, endoplasmic reticulum. 1 To whom correspondence should...