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Keywords: translesion synthesis
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Biochem Soc Trans (2010) 38 (1): 110–115.
Published: 19 January 2010
...Abel C.S. Chun; Dong-Yan Jin In response to DNA damage, TLS (translesion synthesis) allows replicative bypass of various DNA lesions, which stall normal replication. TLS is achieved by low-fidelity polymerases harbouring less stringent active sites. In humans, Y-family polymerases together...
Biochem Soc Trans (2007) 35 (5): 1334–1337.
Published: 25 October 2007
... mutagenesis translesion synthesis ubiquitin The stability of our genetic material is endangered both by DNA-damaging agents from the environment and by endogenous problems during DNA replication arising from spontaneous damage [ 1 ]. DNA repair pathways, the cell's first line of defence against many...