... glycation methylglyoxal proteome transcriptome Glo1 (glyoxalase I) is a protein in the cell cytosol. Glo2 (glyoxalase II) is a protein found in two isoforms, cytosolic and mitochondrial, in cells [ 1 , 2 ]. The molecular characteristics of Glo1 and Glo2 are now well-established and research...

... and mechanisms of action of Tra2β. At a transcriptome-wide level, Tra2β protein binds a matrix of AGAA-rich sequences mapping frequently to exons. Particular tissue-specific alternatively spliced exons contain high concentrations of high scoring Tra2β-binding sites and bind Tra2β strongly in vitro . These top...

... at unprecedented scale and speed. These next-generation technologies make it feasible to sequence not only static genomes, but also entire transcriptomes expressed under different conditions. These and other powerful applications of next-generation sequencing are rapidly revolutionizing the way genomic studies...