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Keywords: transcriptional regulation
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Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... unilateral ureteral obstructive YY1 Ying Yang 1 biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how the eukaryotic genomic code is arranged, regulated and transcribed. Simply...
Articles
Biochem Soc Trans (2015) 43 (4): 595–601.
Published: 03 August 2015
... expression and activity is essential. This regulation is exerted at multiple levels, including transcriptional regulation and proteasomal degradation. Recent studies revealed important roles of miRNAs (miRs) in the control of NRF2 activity through direct targeting of the NRF2 mRNA and of mRNAs encoding...
Articles
Biochem Soc Trans (2013) 41 (6): 1634–1639.
Published: 20 November 2013
.../licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. chromatin fission yeast heterochromatin nuclear organization transcriptional regulation Before the advent of high-throughput molecular biology...
Articles
Biochem Soc Trans (2011) 39 (1): 99–103.
Published: 19 January 2011
... Society 2011 activator archaeon transcriptional regulation transcription factor B-recognition element (BRE) transcription factor B recruitment (TFB recruitment) upstream activator sequence (UAS) The archaeal transcriptional machinery represents a simplified version of the eukaryal...
Articles
Biochem Soc Trans (2010) 38 (1): 263–267.
Published: 19 January 2010
... The Authors Journal compilation © 2010 Biochemical Society 2010 gene positioning genome organization lamin protein nuclear matrix (NM) transcription factory transcriptional regulation Over the past decade, much progress has been made in order to elucidate the nuclear organization...
Articles
Biochem Soc Trans (2008) 36 (6): 1252–1257.
Published: 19 November 2008
...://www.biochemsoctrans.org/bst/036/bst0361252add.htm . genomics metal-regulatory transcription factor 1 (MTF1) small interfering RNA (siRNA) transcriptional regulation zinc MTF1 (metal-regulatory transcription factor 1) was identified as the protein that bound the previously discovered MREs (metal...
Includes: Supplementary data
Articles
Biochem Soc Trans (2008) 36 (4): 609–612.
Published: 22 July 2008
... in transcriptional regulation. In the present paper, we shall review the literature demonstrating the action of p68 and, where data are available, p72 as transcriptional co-regulators for a range of transcription factors, namely ERα (oestrogen receptor α), the tumour suppressor p53, the myogenic regulator MyoD...
Articles
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
... specific histone modifications and chromatin-modifying enzymes. 1 To whom correspondence should be addressed (email i.c.wood@leeds.ac.uk ). 19 3 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 chromatin switching ion channel oncogene transcriptional...
Articles
Biochem Soc Trans (2008) 36 (4): 613–618.
Published: 22 July 2008
... and clinical settings. Transcriptional regulation, the ability to turn genes on and off, lies at the heart of these processes of lineage commitment and specification. We have focused on fully understanding how these decisions are made at a single mammalian gene locus, the α-globin genes, which become up...
Articles
Biochem Soc Trans (2008) 36 (4): 758–765.
Published: 22 July 2008
..., the challenge to understand how the individual genes are regulated within the cell remains. Here, I provide an overview of current computational methods to investigate transcriptional regulation. I will first discuss how representing protein–DNA interactions as a network provides us with a conceptual framework...
Articles
Biochem Soc Trans (2008) 36 (1): 83–88.
Published: 22 January 2008
...-binding protein nucleotide analogue σ 54 transcriptional regulation bEBPs (bacterial enhancer-binding proteins) are AAA+ (ATPase associated with various cellular activities) family members involved in regulating bacterial gene expression. Regulated transcription in bacteria requires...
Articles
Biochem Soc Trans (2008) 36 (1): 89–93.
Published: 22 January 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 ATPase associated with various cellular activites (AAA+) enhancer-binding protein σ 54 small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) transcriptional regulation Bacteria must adapt to environmental changes...
Articles
Biochem Soc Trans (2007) 35 (6): 1427–1429.
Published: 23 November 2007
...F.V. Fuller-Pace; A.-M.F. Jacobs; S.M. Nicol SUMO (small ubiquitin-related modifier) modification is known to have diverse effects on the activity of transcriptional regulators, often through alterations in their localization or interactions with other factors, and in most of the cases...
Articles
Biochem Soc Trans (2006) 34 (5): 783–785.
Published: 25 October 2006
... (email Peter.Piper@sheffield.ac.uk ). 15 6 2006 © 2006 The Biochemical Society 2006 heat-shock protein 90 (Hsp90) heat-shock transcription factor (HSF) mitogen-activated protein kinase signalling (MAPK signalling) Slt2(Mpk1)p transcriptional regulation yeast cell integrity...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... cholesterol liver X receptor (LXR) macrophage peroxisome-proliferator-activated receptor α (PPARα) trafficking transcriptional regulation Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes. Pharmacological modulation...
Articles
Biochem Soc Trans (2006) 34 (1): 185–187.
Published: 20 January 2006
...S. Rinaldo; G. Giardina; M. Brunori; F. Cutruzzolà All denitrifiers can keep the steady-state concentrations of nitrite and nitric oxide (NO) below cytotoxic levels by controlling the expression of denitrification gene clusters by redox signalling through transcriptional regulators belonging...
Articles
Biochem Soc Trans (2005) 33 (6): 1537–1540.
Published: 26 October 2005
.... 1 To whom correspondence should be addressed (email a.bird@ed.ac.uk ). 20 6 2005 © 2005 The Biochemical Society 2005 DNA methylation epigenetic mechanism histone deacetylase methyl-CpG-binding domain protein transcriptional regulation tumorigenesis Another finding...
Articles
Biochem Soc Trans (2005) 33 (6): 1423–1426.
Published: 26 October 2005
... ). 21 6 2005 © 2005 The Biochemical Society 2005 chromatin immunoprecipitation–DNA microarray (ChIP-chip) gene circuit metabolism network component analysis (NCA) transcriptional regulation transcription factor The design was implemented experimentally within E. coli central...
Articles
Biochem Soc Trans (2005) 33 (1): 184–186.
Published: 01 February 2005
... anaerobiosis denitrification nitric oxide Pseudomonas aeruginosa sensor transcriptional regulation In denitrifying bacteria, the concentration of extracellular NO is maintained low (nanomolar) by a tight control of the expression and activity of nitrite and NO reductases. Regulation involves...
Articles
Biochem Soc Trans (2005) 33 (1): 28–32.
Published: 01 February 2005
... to a site close to the −35 promoter recognition site and to a site overlapping the integration host factor DNA-binding site (5′-TCACACACCATTG, centred at −87 nt) and acts as a repressor. H 2 sensor HupUV HupT/HupR integration host factor (IHF) RegA Rhodobacter capsulatus transcriptional...
Articles
Biochem Soc Trans (2005) 33 (1): 195–197.
Published: 01 February 2005
..., and by transcription regulators NarL and NarP in response to nitrite and nitrate. Strains used during this study were E. coli RK 4353 (Δ lacU169 araD139 rpsLgyrA ) [ 5 ], JCB 302 (Δ a chl + RV ) [ 6 ], JCB 3893 (JCB302 narL ), JCB 3894 (JCB302 narL narP ) and JCB 3875 (Δ nir Δ lac narP ). E. coli...
Articles
Biochem Soc Trans (2004) 32 (6): 1008–1010.
Published: 26 October 2004
... transcription factor. 1 To whom correspondence should be addressed (email chb@soton.ac.uk ). 22 7 2004 © 2004 The Biochemical Society 2004 Nramp1 oxidant stress specificity protein 1 (Sp1) transcriptional regulation Nramp1 (murine natural resistance-associated...
Articles
Biochem Soc Trans (2004) 32 (6): 1084–1086.
Published: 26 October 2004
...) [ 13 , 14 ] and, in the case of TGF-β-dependent induction of the p15 INK4B promoter, via the formation of a Smad complex that interacts with Sp1 and is rendered transcriptionally inactive following c-Myc binding. initiator element Miz-1 Nramp1 transcriptional regulation A single gene...