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Keywords: transcriptional regulation
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Articles
Biochem Soc Trans (2017) 45 (4): 953–962.
Published: 07 July 2017
... : rheumatoid arthritis; PACER : several cancers including osteosarcoma. biomarkers disease gene expression inflammation lncRNA transcriptional regulation The ‘noncoding revolution’ [ 1 ] has reformed our understanding of how the eukaryotic genomic code is arranged, regulated...
Articles
Biochem Soc Trans (2015) 43 (4): 595–601.
Published: 03 August 2015
... expression and activity is essential. This regulation is exerted at multiple levels, including transcriptional regulation and proteasomal degradation. Recent studies revealed important roles of miRNAs (miRs) in the control of NRF2 activity through direct targeting of the NRF2 mRNA and of mRNAs encoding...
Articles
Biochem Soc Trans (2013) 41 (6): 1634–1639.
Published: 20 November 2013
... from one nuclear compartment to another, nuclear structures might not only be relevant as a reference point, but also indicate a biological function [ 2 , 3 ]. chromatin fission yeast heterochromatin nuclear organization transcriptional regulation Before the advent of high-throughput...
Articles
Biochem Soc Trans (2011) 39 (1): 99–103.
Published: 19 January 2011
... (email qunxin@bio.ku.dk ). 16 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 activator archaeon transcriptional regulation transcription factor B-recognition element (BRE) transcription factor B recruitment (TFB recruitment) upstream activator sequence...
Articles
Biochem Soc Trans (2010) 38 (1): 263–267.
Published: 19 January 2010
... genome organization lamin protein nuclear matrix (NM) transcription factory transcriptional regulation The NM or nucleoskeleton is proposed to be a permanent network of core filaments, underlying thicker fibres, present regardless of transcriptional activity. It is found to be both RNA...
Articles
Biochem Soc Trans (2008) 36 (6): 1252–1257.
Published: 19 November 2008
... responses. A simple example is provided by those experiments that have associated zinc-responsive genes with MTF1 regulation using single time-point data. This approach, although informative in relation to zinc, makes the following assumptions: (i) no secondary zinc-mediated transcriptional regulators...
Includes: Supplementary data
Articles
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
... enzymes regulate transcription would provide insight into the functional interactions between specific histone modifications and chromatin-modifying enzymes. chromatin switching ion channel oncogene transcriptional regulation tumour suppressor vascular disease © The Authors Journal...
Articles
Biochem Soc Trans (2008) 36 (4): 609–612.
Published: 22 July 2008
... in transcriptional regulation. In the present paper, we shall review the literature demonstrating the action of p68 and, where data are available, p72 as transcriptional co-regulators for a range of transcription factors, namely ERα (oestrogen receptor α), the tumour suppressor p53, the myogenic regulator MyoD...
Articles
Biochem Soc Trans (2008) 36 (4): 758–765.
Published: 22 July 2008
..., the challenge to understand how the individual genes are regulated within the cell remains. Here, I provide an overview of current computational methods to investigate transcriptional regulation. I will first discuss how representing protein–DNA interactions as a network provides us with a conceptual framework...
Articles
Biochem Soc Trans (2008) 36 (4): 613–618.
Published: 22 July 2008
... and clinical settings. Transcriptional regulation, the ability to turn genes on and off, lies at the heart of these processes of lineage commitment and specification. We have focused on fully understanding how these decisions are made at a single mammalian gene locus, the α-globin genes, which become up...
Articles
Biochem Soc Trans (2008) 36 (1): 83–88.
Published: 22 January 2008
...-binding protein nucleotide analogue σ 54 transcriptional regulation bEBPs (bacterial enhancer-binding proteins) are AAA+ (ATPase associated with various cellular activities) family members involved in regulating bacterial gene expression. Regulated transcription in bacteria requires...
Articles
Biochem Soc Trans (2008) 36 (1): 89–93.
Published: 22 January 2008
... The Authors Journal compilation © 2008 Biochemical Society 2008 ATPase associated with various cellular activites (AAA+) enhancer-binding protein σ 54 small-angle X-ray scattering/wide-angle X-ray scattering (SAXS/WAXS) transcriptional regulation Bacteria must adapt to environmental changes...
Articles
Biochem Soc Trans (2007) 35 (6): 1427–1429.
Published: 23 November 2007
...F.V. Fuller-Pace; A.-M.F. Jacobs; S.M. Nicol SUMO (small ubiquitin-related modifier) modification is known to have diverse effects on the activity of transcriptional regulators, often through alterations in their localization or interactions with other factors, and in most of the cases...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... transcriptional regulation Altered macrophage functions contribute to the pathogenesis of many infectious, immunological and inflammatory disease processes. Pharmacological modulation of macrophage gene expression therefore represents an important strategy for the prevention and treatment of inflammation...
Articles
Biochem Soc Trans (2006) 34 (5): 783–785.
Published: 25 October 2006
... be addressed (email Peter.Piper@sheffield.ac.uk ). 15 6 2006 © 2006 The Biochemical Society 2006 heat-shock protein 90 (Hsp90) heat-shock transcription factor (HSF) mitogen-activated protein kinase signalling (MAPK signalling) Slt2(Mpk1)p transcriptional regulation yeast cell integrity...
Articles
Biochem Soc Trans (2006) 34 (1): 185–187.
Published: 20 January 2006
...S. Rinaldo; G. Giardina; M. Brunori; F. Cutruzzolà All denitrifiers can keep the steady-state concentrations of nitrite and nitric oxide (NO) below cytotoxic levels by controlling the expression of denitrification gene clusters by redox signalling through transcriptional regulators belonging...
Articles
Biochem Soc Trans (2005) 33 (6): 1423–1426.
Published: 26 October 2005
... ). 21 6 2005 © 2005 The Biochemical Society 2005 chromatin immunoprecipitation–DNA microarray (ChIP-chip) gene circuit metabolism network component analysis (NCA) transcriptional regulation transcription factor Large-Scale Screening: A Focus Topic at BioScience2005, held...
Articles
Biochem Soc Trans (2005) 33 (6): 1537–1540.
Published: 26 October 2005
.... 1 To whom correspondence should be addressed (email a.bird@ed.ac.uk ). 20 6 2005 © 2005 The Biochemical Society 2005 DNA methylation epigenetic mechanism histone deacetylase methyl-CpG-binding domain protein transcriptional regulation tumorigenesis Another finding...
Articles
Biochem Soc Trans (2005) 33 (1): 184–186.
Published: 01 February 2005
... francesca.cutruzzola@uniroma1.it ). 5 9 2004 © 2005 The Biochemical Society 2005 anaerobiosis denitrification nitric oxide Pseudomonas aeruginosa sensor transcriptional regulation where I is the observed fluorescence intensity, K is the dissociation constant for a dye–site complex...
Articles
Biochem Soc Trans (2005) 33 (1): 28–32.
Published: 01 February 2005
... The Biochemical Society 2005 H 2 sensor HupUV HupT/HupR integration host factor (IHF) RegA Rhodobacter capsulatus transcriptional regulation In the photosynthetic bacterium Rhodobacter capsulatus , the ability to use H 2 as an electron donor is conferred by a membrane-bound [NiFe...
Articles
Biochem Soc Trans (2005) 33 (1): 195–197.
Published: 01 February 2005
... for physiological studies. 1 To whom correspondence should be addressed (email NXF122@bham.ac.uk ). 25 9 2004 © 2005 The Biochemical Society 2005 anaerobiosis hybrid-cluster protein iron–sulphur–oxygen cluster nitrogen cycle transcription start mapping transcriptional regulation...
Articles
Biochem Soc Trans (2004) 32 (6): 1084–1086.
Published: 26 October 2004
... S.C. Biochem. J. 2003 370 291 298 13 Feng X.H. Lin X. Derynck R. EMBO J. 2000 19 5178 5193 14 Feng X.H. Liang Y.Y. Liang M. Zhai W. Lin X. Mol. Cell 2002 9 133 143 initiator element Miz-1 Nramp1 transcriptional...
Articles
Biochem Soc Trans (2004) 32 (6): 1008–1010.
Published: 26 October 2004
.... Kubilis J. Ferrante R.J. Ross B.D. Neve R. Ratan R.R. J. Neurosci. 2003 23 3597 3606 © 2004 The Biochemical Society 2004 Nramp1 oxidant stress specificity protein 1 (Sp1) transcriptional regulation Nramp1 (murine natural resistance-associated...