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Keywords: transcription factor
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Articles
Biochem Soc Trans (2021) 49 (2): 579–590.
Published: 05 March 2021
... cells to alternative identities have advanced dramatically. Cellular identity is determined by the transcriptional profile which comprises the subset of mRNAs, and therefore proteins, being expressed by a cell at a given point in time. A better understanding of the levers governing transcription factor...
Articles
Biochem Soc Trans (2018) 46 (4): 945–956.
Published: 31 July 2018
...Maxime Woringer; Xavier Darzacq Understanding how transcription factors (TFs) regulate mammalian gene expression in space and time is a central topic in biology. To activate a gene, a TF has first to diffuse in the available space of the nucleus until it reaches a target DNA sequence or protein...
Articles
Biochem Soc Trans (2014) 42 (4): 747–751.
Published: 11 August 2014
... in the clinic many drug-resistant forms of blood cancers. In the present article, we uncover the relationship that exists in human leukaemia life/death switching between the anti-apoptotic pro-inflammatory transcription factor NF-κB (nuclear factor κB) and the cytoprotective antioxidant-responsive transcription...
Articles
Biochem Soc Trans (2013) 41 (6): 1696–1700.
Published: 20 November 2013
...Gordon Chua Mapping transcriptional-regulatory networks requires the identification of target genes, binding specificities and signalling pathways of transcription factors. However, the characterization of each transcription factor sufficiently for deciphering such networks remains laborious...
Articles
Biochem Soc Trans (2013) 41 (1): 368–373.
Published: 29 January 2013
.... As these events play out on the nanometre scale, new biophysical approaches have been employed to monitor conformational changes in this regime at the single-molecule level. Focusing on transcription factor action on promoter DNA, we discuss how current biophysical techniques are able to quantitatively describe...
Articles
Biochem Soc Trans (2011) 39 (1): 294–298.
Published: 19 January 2011
... transcription factors. These regulators are involved in many different pathways and distinct activation mechanism seems to be operative in several cases. Recent results indicate that DNR is a haem protein capable of discriminating between NO and CO (carbon monoxide). On the basis of the available structural...
Articles
Biochem Soc Trans (2010) 38 (6): 1593–1597.
Published: 24 November 2010
... involving Ig gene rearrangements. Classic mechanisms for B-cell oncogenesis are dependent upon deregulation of gene expression, with many translocated proto-oncogenes being transcription factors. More recently, and particularly since the discovery of miRNAs (microRNAs), it has become clear that deregulation...
Articles
Biochem Soc Trans (2010) 38 (2): 613–616.
Published: 22 March 2010
... 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 developmental timing floral meristem histone modification stem cell transcription factor In Arabidopsis reproductive development, SAMs (shoot apical meristems) produce inflorescences bearing flowers...
Articles
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
... Society 2009 brain gene expression neuronal disease RNA transcription factor translation This papers in this issue of Biochemical Society Transactions arise from our meeting Gene Expression in Neuronal Disease held on 16–18 July 2009 in Cardiff. We were interested in following...
Articles
Biochem Soc Trans (2009) 37 (6): 1263–1269.
Published: 19 November 2009
... an unusual monogenic disorder, characterized by problems with articulating speech along with deficits in expressive and receptive language. FOXP2 encodes a regulatory protein, belonging to the forkhead box family of transcription factors, known to play important roles in modulating gene expression...
Articles
Biochem Soc Trans (2008) 36 (4): 637–639.
Published: 22 July 2008
... To whom correspondence should be addressed (email A.J.Sinclair@Sussex.ac.uk ). 1 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 basic leucine zipper (bZIP) DNA binding epigenetics methylation transcription factor virus Infection with EBV...
Articles
Biochem Soc Trans (2008) 36 (4): 758–765.
Published: 22 July 2008
... to understand the organization of regulatory interactions in an organism. I will then describe methods to predict transcription factors and cis -regulatory elements using information such as sequence, structure and evolutionary conservation. Finally, I will discuss approaches to infer genome-scale...
Articles
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
... ). 19 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing Arabidopsis precursor mRNA splicing factor transcription factor Pre-mRNA (precursor mRNA) splicing is the excision of intron sequences from pre-mRNAs mediated...
Articles
Biochem Soc Trans (2007) 35 (5): 890–894.
Published: 25 October 2007
... mitogen-activated protein kinase NF-κB nuclear factor κB REST repressor element 1-silencing transcription factor TRP transient receptor potential TRPC TRP canonical TRPV TRP vanilloid VSMC vascular smooth-muscle cell This study was funded by the British Heart...
Articles
Biochem Soc Trans (2007) 35 (5): 942–945.
Published: 25 October 2007
...J. Terzic; I. Marinovic-Terzic; F. Ikeda; I. Dikic The NF-κB (nuclear factor κB) transcription factors control cell survival, proliferation and innate and adaptive immune response. Post-translational modifications of key components of the NF-κB pathway provide the molecular basis for signal...
Articles
Biochem Soc Trans (2006) 34 (5): 696–700.
Published: 25 October 2006
... of the genes involved in exocytosis is urgently needed. Recent studies have led to the identification of transcription factors and other regulatory molecules such as microRNAs that modulate the cellular level of key controllers of the exocytotic process. These findings furnish a new perspective...
Articles
Biochem Soc Trans (2006) 34 (5): 791–793.
Published: 25 October 2006
...R. An; G. da Silva Xavier; H.-X. Hao; F. Semplici; J. Rutter; G.A. Rutter The transcription factor PDX-1 ( p ancreatic d uodenal homeobo x -1) is required for normal pancreatic development and for the function of insulin-producing islet β-cells in mammals. We have shown previously that glucose...
Articles
Biochem Soc Trans (2005) 33 (6): 1423–1426.
Published: 26 October 2005
... to elucidate transcription factor dynamics in Saccharomyces cerevisiae cell-cycle regulation, detect cross-talks in Escherichia coli two-component signalling pathways, and characterize E. coli carbon source transition. An ultimate test of system-wide understanding is the ability to design and construct novel...
Articles
Biochem Soc Trans (2005) 33 (6): 1502–1506.
Published: 26 October 2005
... plant domestication ramosa1 transcription factor Plants, through their ability to harvest light energy and convert it into chemical energy, are the primary producers on which life on earth depends. Not surprisingly then, humans have domesticated plants by cultivation and selection...
Articles
Biochem Soc Trans (2005) 33 (1): 272–275.
Published: 01 February 2005
...) type transcription factor AtbZIP11 / ATB2 . This sucrose-induced repression of translation (SIRT) depends on translation of a highly conserved upstream open reading frame (uORF) in the 5′ UTR of the gene. This conserved uORF is exclusively encoded in 5′ UTRs of several plant S-class bZIP transcription...
Articles
Biochem Soc Trans (2004) 32 (1): 88–91.
Published: 01 February 2004
... and the formation of foam cells, and that AP-1 (activator protein 1)/ets were necessary transcriptional factors for Scr induction in HMCs (human kidney mesangial cells). Most cells are protected from excessive native LDL (low-density lipoprotein) accumulation by tight feedback regulation of the LDLr (LDL receptor...
Articles
Biochem Soc Trans (2003) 31 (6): 1125–1129.
Published: 01 December 2003
...-activated receptor re-esterification thiazolidinedione transcription factor Abbreviations used: COUP-TF, chicken ovalbumin upstream promoter–transcription factor; DR1, direct repeat 1; G3P, glycerol 3-phosphate; FA, fatty acid; PEPCK-C, cytosolic phosphoenolpyruvate carboxykinase (GTP); PPAR...
Articles
Biochem Soc Trans (2003) 31 (1): 224–227.
Published: 01 February 2003
... and regulates proteins involved in gene transcription. There are now several examples of transcription factors, cofactors and components of the transcriptional core machinery that are directly phosphorylated and regulated by AMPK. Here I review these examples and discuss the significance of AMPK activity...
Articles
Biochem Soc Trans (2003) 31 (1): 56–59.
Published: 01 February 2003
... pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation. activation function 2 ligand binding steroid receptor transcription factor Abbreviations used: AF1, activation function 1; AF2...
Articles
Biochem Soc Trans (2002) 30 (6): 1091–1095.
Published: 01 November 2002
...J. D. Horton Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP iso-forms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids...
Articles
Biochem Soc Trans (2000) 28 (4): 396–400.
Published: 01 August 2000
... transcription factor AF1, activation function I AF2, activation function 2 ER, oestrogen receptor E2, 17-β-oestradiol LBD, ligand-binding domain NR, nuclear receptor RAL, raloxifene Biochemical Society Transactions (2000) Volume 28, part 4 6 Chen, J. D., Umesono, K. and Evans, R M. ( I 996) Proc...