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Keywords: transcription factor
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Articles
Biochem Soc Trans (2023) 51 (6): 2085–2092.
Published: 14 December 2023
... of California in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with UC. HDX-MS inflammation single molecule fret transcription factor The nuclear factor-κB (NF-κB) signaling system involves a family of NF-κB...
Articles
Articles
Biochem Soc Trans (2018) 46 (4): 945–956.
Published: 31 July 2018
...Maxime Woringer; Xavier Darzacq Understanding how transcription factors (TFs) regulate mammalian gene expression in space and time is a central topic in biology. To activate a gene, a TF has first to diffuse in the available space of the nucleus until it reaches a target DNA sequence or protein...
Articles
Biochem Soc Trans (2014) 42 (4): 747–751.
Published: 11 August 2014
... in the clinic many drug-resistant forms of blood cancers. In the present article, we uncover the relationship that exists in human leukaemia life/death switching between the anti-apoptotic pro-inflammatory transcription factor NF-κB (nuclear factor κB) and the cytoprotective antioxidant-responsive transcription...
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Articles
Biochem Soc Trans (2013) 41 (1): 368–373.
Published: 29 January 2013
.... As these events play out on the nanometre scale, new biophysical approaches have been employed to monitor conformational changes in this regime at the single-molecule level. Focusing on transcription factor action on promoter DNA, we discuss how current biophysical techniques are able to quantitatively describe...
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Articles
Biochem Soc Trans (2010) 38 (6): 1593–1597.
Published: 24 November 2010
... ribosomal entry segment (IRES) microRNA (miRNA) transcription factor Lymphomas are a disparate group of neoplastic disorders of lymphoid tissues. In the West, lymphomas have an incidence of one case per 5000 people, and, of these, 95% are of B-cell origin. Within B-cell lymphomas, distinction...
Articles
Biochem Soc Trans (2010) 38 (2): 613–616.
Published: 22 March 2010
... compilation © 2010 Biochemical Society 2010 developmental timing floral meristem histone modification stem cell transcription factor In Arabidopsis reproductive development, SAMs (shoot apical meristems) produce inflorescences bearing flowers. Initiated from the flanks of the inflorescence...
Articles
Biochem Soc Trans (2009) 37 (6): 1261–1262.
Published: 19 November 2009
... To whom correspondence should be addressed (email jonesl1@Cardiff.ac.uk ). 5 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 brain gene expression neuronal disease RNA transcription factor translation This papers in this issue of Biochemical Society...
Articles
Biochem Soc Trans (2009) 37 (6): 1263–1269.
Published: 19 November 2009
... an unusual monogenic disorder, characterized by problems with articulating speech along with deficits in expressive and receptive language. FOXP2 encodes a regulatory protein, belonging to the forkhead box family of transcription factors, known to play important roles in modulating gene expression...
Articles
Biochem Soc Trans (2008) 36 (4): 758–765.
Published: 22 July 2008
... to understand the organization of regulatory interactions in an organism. I will then describe methods to predict transcription factors and cis -regulatory elements using information such as sequence, structure and evolutionary conservation. Finally, I will discuss approaches to infer genome-scale...
Articles
Biochem Soc Trans (2008) 36 (4): 637–639.
Published: 22 July 2008
.... Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter Genes Dev. 1988 2 1136 1143 17 Sinclair A.J. Unexpected structure of Epstein–Barr virus lytic cycle activator Zta Trends Microbiol...
Articles
Biochem Soc Trans (2008) 36 (3): 508–510.
Published: 21 May 2008
... ). 19 2 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 alternative splicing Arabidopsis precursor mRNA splicing factor transcription factor We acknowledge funding for this research from the European Alternative Splicing Network of Excellence (EURASNET...
Articles
Biochem Soc Trans (2007) 35 (5): 942–945.
Published: 25 October 2007
...J. Terzic; I. Marinovic-Terzic; F. Ikeda; I. Dikic The NF-κB (nuclear factor κB) transcription factors control cell survival, proliferation and innate and adaptive immune response. Post-translational modifications of key components of the NF-κB pathway provide the molecular basis for signal...
Articles
Biochem Soc Trans (2007) 35 (5): 890–894.
Published: 25 October 2007
... channel transcription factor vascular smooth-muscle cell (VSMC) VSMCs (vascular smooth-muscle cells) are best known as the contractile cells of arteries and veins, regulating vessel calibre and thus determining tissue perfusion and venous drainage throughout the body. Not only must the cells...
Articles
Biochem Soc Trans (2006) 34 (5): 696–700.
Published: 25 October 2006
... of the genes involved in exocytosis is urgently needed. Recent studies have led to the identification of transcription factors and other regulatory molecules such as microRNAs that modulate the cellular level of key controllers of the exocytotic process. These findings furnish a new perspective...
Articles
Biochem Soc Trans (2006) 34 (5): 791–793.
Published: 25 October 2006
...R. An; G. da Silva Xavier; H.-X. Hao; F. Semplici; J. Rutter; G.A. Rutter The transcription factor PDX-1 ( p ancreatic d uodenal homeobo x -1) is required for normal pancreatic development and for the function of insulin-producing islet β-cells in mammals. We have shown previously that glucose...
Articles
Biochem Soc Trans (2005) 33 (6): 1423–1426.
Published: 26 October 2005
... to elucidate transcription factor dynamics in Saccharomyces cerevisiae cell-cycle regulation, detect cross-talks in Escherichia coli two-component signalling pathways, and characterize E. coli carbon source transition. An ultimate test of system-wide understanding is the ability to design and construct novel...
Articles
Biochem Soc Trans (2005) 33 (6): 1502–1506.
Published: 26 October 2005
... the oldest [ 35 ]. Almost a century later, molecular analysis [ 47 ] reveals that ra1 encodes a transcription factor that regulates meristems to control the branching architecture of inflorescences ( Figure 3 ). At least one other classical mutant, ramosa2 , controls branching similarly, through the ra1...
Articles
Biochem Soc Trans (2005) 33 (1): 272–275.
Published: 01 February 2005
...) type transcription factor AtbZIP11 / ATB2 . This sucrose-induced repression of translation (SIRT) depends on translation of a highly conserved upstream open reading frame (uORF) in the 5′ UTR of the gene. This conserved uORF is exclusively encoded in 5′ UTRs of several plant S-class bZIP transcription...
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Articles
Biochem Soc Trans (2003) 31 (6): 1125–1129.
Published: 01 December 2003
... proliferator-activated receptor re-esterification thiazolidinedione transcription factor The Glucose/Fatty Acid Cycle 1963 2003 1125 Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase C. Forest*1, J. Tordjman*, M. Glorian*, E. Duplus*2, G. Chauvet*, J...
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Biochem Soc Trans (2003) 31 (1): 56–59.
Published: 01 February 2003
... held at University of Liverpool, Liverpool, 4–6 September 2002 7 October 2002 Copyright 2003 Biochemical Society 2003 activation function 2 ligand binding steroid receptor transcription factor Abbreviations used: AF1, activation function 1; AF2, activation function 2...
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Biochem Soc Trans (2003) 31 (1): 224–227.
Published: 01 February 2003
... and regulates proteins involved in gene transcription. There are now several examples of transcription factors, cofactors and components of the transcriptional core machinery that are directly phosphorylated and regulated by AMPK. Here I review these examples and discuss the significance of AMPK activity...
Articles
Biochem Soc Trans (2002) 30 (6): 1091–1095.
Published: 01 November 2002
...J. D. Horton Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP iso-forms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids...
Articles
Biochem Soc Trans (2000) 28 (4): 396–400.
Published: 01 August 2000
... transcription factor AF1, activation function I AF2, activation function 2 ER, oestrogen receptor E2, 17-β-oestradiol LBD, ligand-binding domain NR, nuclear receptor RAL, raloxifene Biochemical Society Transactions (2000) Volume 28, part 4 6 Chen, J. D., Umesono, K. and Evans, R M. ( I 996) Proc...