... 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 DNA binding domain glucocorticoid receptor ligand binding domain transactivation transrepression Glucocorticoid receptor (GR) is a member of nuclear receptor (NR) superfamily subgroup 3...

... shuttling of RelA-containing complexes. It has also been suggested that this region may contain a mini-leucine zipper (Leu 435 , Leu 443 and Leu 450 ), which, when removed, reduces transactivation [ 10 ]. Subsequently, it was found that mutation of Leu 443 alone was shown to curtail transactivation [ 18...

...@man.ac.uk ). 23 7 2004 © 2004 The Biochemical Society 2004 preinitiation complex promoter RNA polymerase II transcription factor IIB (TFIIB) transactivation transcription Accurate initiation of class II (protein encoding) gene transcription in eukaryotes requires the assembly...

...L. Ryabova; H.-S. Park; T. Hohn Translation of the polycistronic 35S RNA of CaMV (cauliflower mosaic virus) occurs via a reinitiation mechanism, which requires TAV (transactivator/viroplasmin). To allow translation reinitiation of the major open reading frames on the polycistronic RNA, TAV...

.... The molecular mechanisms of EGFR signal transactivation involve processing of transmembrane growth factor precursors by metalloproteases which have been recently identified as members of the ADAM ( a d isintegrin a nd m etalloprotease) family of zinc-dependent proteases. Subsequently, the EGFR transmits signals...

... shown to be important for transactivation and protein–protein interactions; however, little is known about the structure and folding of this region. Folding of the AR transactivation domain was observed in the presence of the helix-stabilizing solvent trifluorethanol and the natural osmolyte TMAO...

... with PDGF transactivated EDG-1 as determined by translocation of β-arrestin and phosphorylation of EDG-1. These findings reveal a new paradigm for receptor cross-communication in which activation of a GPCR by a receptor tyrosine kinase is critical for cell motility. Our observations might also clarify...