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Keywords: trafficking
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Articles
Biochem Soc Trans (2024) 52 (2): 505–515.
Published: 17 April 2024
...Edward J. Chocano-Coralla; Luis Vidali In eukaryotic cells, organelle and vesicle transport, positioning, and interactions play crucial roles in cytoplasmic organization and function. These processes are governed by intracellular trafficking mechanisms. At the core of that trafficking...
Articles
Biochem Soc Trans (2024) 52 (1): 41–53.
Published: 22 February 2024
... in cardiomyocytes have begun to unveil essential functions for these enzymes in regulating cardiac development, homeostasis, and pathogenesis. Palmitoylation co-ordinates cardiac electrophysiology through direct modulation of ion channels and transporters to impact their trafficking or gating properties as well...
Articles
Biochem Soc Trans (2023) 51 (4): 1621–1633.
Published: 03 August 2023
... 2023 GTPases inflammasome innate immunity interferons trafficking virus replication The innate immune system is the primary line of defence against infection. In vertebrates, specialized pattern recognition receptors (PRRs) sense the pathogen associated molecular patterns (PAMPs...
Articles
Biochem Soc Trans (2023) 51 (3): 971–981.
Published: 19 June 2023
... of Cleveland Clinic in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with Individual. endoplasmic reticulum glycoproteins golgi apparatus LMAN1–MCFD2 SURF4 trafficking Compared with single-cell eukaryotes like...
Articles
Biochem Soc Trans (2023) 51 (3): 1057–1069.
Published: 30 May 2023
... converges on multiple trafficking processes to deliver the glucose transporter GLUT4 to the cell surface. Impaired insulin-stimulated GLUT4 translocation in these tissues underlies insulin resistance, which is a major risk factor for type 2 diabetes and other metabolic diseases. Despite this, the precise...
Articles
Biochem Soc Trans (2023) 51 (2): 579–585.
Published: 09 March 2023
... of macropinocytosis as described in the text. actin dynamics cell migration endocytosis macropinocytosis trafficking Actin-based protrusions at the plasma membrane allow the cell to explore space in all directions and to make new contacts with or even engulf samples of extracellular substances...
Articles
Biochem Soc Trans (2023) 51 (1): 331–342.
Published: 23 February 2023
... of new functions that include lipogenesis and Golgi vesicle trafficking. Here, we review recent insights into the role of CaMKK2 in membrane trafficking mechanisms and discuss the functional implications in a cellular context and for disease. Correspondence: Emma Evergren ( E.Evergren@qub.ac.uk...
Articles
Biochem Soc Trans (2023) 51 (1): 315–330.
Published: 11 January 2023
... scaling. The different AMPA receptor subunits (GluA1–GluA4) share a common modular structure and membrane topology, and their intracellular C-terminus tail is responsible for the interaction with intracellular proteins important in receptor trafficking. The latter sequence differs between subunits...
Articles
Biochem Soc Trans (2021) 49 (1): 507–517.
Published: 22 February 2021
...-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within...
Articles
Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
...@manchester.ac.uk ) 11 11 2020 25 1 2021 29 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell wall cellulose synthase complex oligomerization phosphorylation/dephosphorylation protein–protein interactions trafficking...
Articles
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
... (Hh), the precise, cell cycle dependent orchestration of the MAPK-pathway appears to relay Ras activation in this context. We will examine how non-canonical activities of K-Ras4B (hereafter K-Ras) could be enabled by its trafficking chaperones calmodulin and PDE6D/PDEδ. Both dynamically localize...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties...
Articles
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
...@vanderbilt.edu ) or Lauren P. Jackson ( lauren.p.jackson@vanderbilt.edu ) 16 8 2020 10 9 2020 14 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 coat proteins cryo-electron microscopy endosome trafficking Membrane...
Articles
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...-explored, how exactly does a single cell interpret a plethora of time-varying signals? Furthermore, how their subsequent responses at the single cell level manifest in the larger context of a developing tissue is unknown. At the same time, the biophysics and chemistry of how receptors are trafficked...
Articles
Biochem Soc Trans (2020) 48 (1): 83–93.
Published: 17 February 2020
... endowed with low and high affinity for ECM ligands. Increasing evidence proves that, differently to what hypothesized in the past, detachment from the ECM and conformational inactivation are not mandatory for integrin to get endocytosed and trafficked. Specific transmembrane and cytosolic proteins...
Articles
Biochem Soc Trans (2018) 46 (1): 43–50.
Published: 22 December 2017
... trafficking [Int. J. Mol. Sci. (2013) 14 , 18670–18681; Traffic (2000) 1 , 836–851]. How then does the cell organize this enormous transfer of material in its crowded internal environment? And how specifically do vesicles carrying proteins and lipids recognize and fuse with the correct compartment...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which...
Articles
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... through its Bin–Amphiphysin–Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent...
Articles
Biochem Soc Trans (2017) 45 (2): 489–497.
Published: 13 April 2017
..., CD81, and CD63 and their interaction partners in host cell entry by human cytomegalo- and human papillomaviruses. Moreover, we discuss a model for tetraspanin assembly into trafficking platforms at the plasma membrane. These platforms might persist during intracellular viral trafficking...
Articles
Biochem Soc Trans (2016) 44 (6): 1737–1744.
Published: 02 December 2016
... protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans , have revealed both that dimerization of this protein is essential for correct trafficking...
Articles
Biochem Soc Trans (2016) 44 (5): 1273–1280.
Published: 19 October 2016
... to solution is shown in red. Correspondence: Shehab Ismail ( s.ismail@beatson.gla.ac.uk ) 19 5 2016 22 7 2016 26 7 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cilia G-proteins trafficking Primary cilia...
Articles
Biochem Soc Trans (2016) 44 (3): 891–897.
Published: 09 June 2016
... for trafficking. Receptors can follow two pathways: a canonical and an alternative pathway. The first route is AP1-dependent and traffics through late endosomes, whereas the latter is AP3-dependent and traffics independent of late endosomes. Hence, despite a large diversification of the lumenal cargo binding...
Articles
Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
...Heather Currinn; Thomas Wassmer Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking events. Due...
Articles
Biochem Soc Trans (2015) 43 (3): 508–512.
Published: 01 June 2015
... regulating the trafficking of the cardiac sodium channel Na V 1.5 to the membrane. The mechanical connections in adherens junctions and desmosomes both include proteins of the cadherin family. The cadherin family is a class of proteins that dock with cadherins from neighbouring cells in a calcium dependent...
Articles
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
... findings regarding Ca 2+ buffering by mitochondria in astrocytes and draw upon emerging evidence highlighting the importance of mitochondrial trafficking dynamics and positioning within astrocyte processes. We also briefly discuss what is known about mitochondrial turnover in astrocytes. 1...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
... phosphatidylinositol 3-phosphate (PI3K) phosphoinositide 3-kinase (PI3K) trafficking The second study found impaired turning and cardiac tube looping as well as lack of Lefty1 / 2 and Nodal in PI3K-C2α −/− embryos at the one- and five-somite stage, suggesting that PI3K-C2α is required for left–right...
Articles
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
...Nicol Birsa; Rosalind Norkett; Nathalie Higgs; Guillermo Lopez-Domenech; Josef T. Kittler Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a precisely distributed and healthy mitochondrial...
Articles
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
...) mammalian target of rapamycin complex 1 (mTORC1) protein kinase B (PKB) trafficking The metabolic switch to aerobic glycolysis is initiated by TCR (T-cell receptor) activation and then maintained in certain T-cell subsets by cytokines such as IL-2 (interleukin-2) and is crucial for normal T-cell...
Articles
Biochem Soc Trans (2013) 41 (1): 225–230.
Published: 29 January 2013
... J. Cooke A. E. Nilsson M. Gould G. W. Mundell S. Milligan G. Plevin R. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) J. Biol. Chem 2012 287 16656 16669 36 Zhong X. Kriz R...
Articles
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Biochem Soc Trans (2012) 40 (6): 1409–1415.
Published: 21 November 2012
... of the Rab11 pathway in the trafficking, assembly and budding steps of these viruses. The Rab family of GTPases play crucial roles in directing cellular vesicular transport throughout the endosomal system, as individual Rab proteins serve as identity markers for a variety of membrane compartments and also...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... have demonstrated the essential role of these proteins in lysosomal acidification, transport of metabolites resulting from hydrolytic degradation and interaction and fusion with other cellular membrane systems. In addition, trafficking pathways of lysosomal membrane proteins are closely linked...
Articles
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
..., membrane-associated tau is dephosphorylated at serine/threonine residues, suggesting that the phosphorylation state of tau regulates its intracellular trafficking. Dephosphorylation of tau may increase the association of tau with trafficking proteins which target tau to the plasma membrane. Thus...
Articles
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
...Jonathan G. Hanley An important mechanism for the regulation of excitatory synaptic transmission in the hippocampus involves tight control of AMPAR [AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor] trafficking to alter the number or subtype of synaptic receptors...
Articles
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...). In addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic...
Articles
Biochem Soc Trans (2007) 35 (5): 1060–1063.
Published: 25 October 2007
... but by inhibition of hERG/ I Kr trafficking to the cell surface. Important examples are antineoplastic Hsp90 (heat-shock protein 90) inhibitors such as (i) geldanamycin, (ii) the leukaemia drug arsenic trioxide, (iii) the antiprotozoical pentamidine, (iv) probucol, a cholesterol-lowering drug, and (v) fluoxetine...
Articles
Biochem Soc Trans (2007) 35 (5): 1069–1073.
Published: 25 October 2007
...D.F. Steele; A. Dehghani Zadeh; M.E. Loewen; D. Fedida The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve...
Articles
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
..., it has been shown that disease pathogenesis in LQT1 can be influenced by the abnormal trafficking of KCNQ1. In comparison, whether defective trafficking of KCNE1 plays a role in LQT5 is less well established. 1 To whom correspondence should be addressed (email a.tinker@ucl.ac.uk ). 5 7...
Articles
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
..., involving environmental factors and de novo mutations. Some of these mutations affect the trafficking of the channels to the cell surface, but as seen with the GABA A Rs, wild-type channel trafficking can also be affected. Auxiliary proteins that regulate ion channel function and trafficking may also...
Articles
Biochem Soc Trans (2006) 34 (5): 877–881.
Published: 25 October 2006
...F.A. Stephenson The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABA A (γ-aminobutyric acid type...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... trafficking in macrophages. 1 To whom correspondence should be addressed (email bart.staels@pasteur-lille.fr ). 25 7 2006 © 2006 The Biochemical Society 2006 cholesterol liver X receptor (LXR) macrophage peroxisome-proliferator-activated receptor α (PPARα) trafficking...
Articles
Biochem Soc Trans (2006) 34 (1): 48–50.
Published: 20 January 2006
...K. Pozo; F.A. Stephenson GRIF-1 [GABA A (γ-aminobutyric acid A ) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail...
Articles
Biochem Soc Trans (2004) 32 (6): 1040–1044.
Published: 26 October 2004
... of small G-proteins with GPCRs and GPCR-regulatory proteins may influence GPCR signalling and intracellular trafficking. 1 To whom correspondence should be addressed, at Cell Biology Research Group, Robarts Research Institute (email ferguson@robarts.ca ). 21 6 2004 AT 1A R...
Articles
Biochem Soc Trans (2004) 32 (1): 1–14.
Published: 01 February 2004
... and function, are trafficked to their required destination. Endocytosis plays, therefore, an important role in cell signalling, nutrient uptake, cellular homoeostasis and the interaction of the cell with its external environment. The formation of clathrin-coated endocytic vesicles requires the complex...
Articles
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
... with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts...
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Articles
Biochem Soc Trans (2001) 29 (4): 500–504.
Published: 01 August 2001
... carriers and membrane pathways that mediate the endocytic trafficking of specific GPCRs. Insights into the biochemical and functional properties of endocytic vesicles containing internalized opioid and adrenergic receptors will be discussed. Progress towards understanding the mechanisms that control...