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Keywords: trafficking
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Articles
Biochem Soc Trans (2021) 49 (1): 507–517.
Published: 22 February 2021
...-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within...
Articles
Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
...@manchester.ac.uk ) 11 11 2020 25 1 2021 29 1 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cell wall cellulose synthase complex oligomerization phosphorylation/dephosphorylation protein–protein interactions trafficking...
Articles
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
... (Hh), the precise, cell cycle dependent orchestration of the MAPK-pathway appears to relay Ras activation in this context. We will examine how non-canonical activities of K-Ras4B (hereafter K-Ras) could be enabled by its trafficking chaperones calmodulin and PDE6D/PDEδ. Both dynamically localize...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties...
Articles
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
...@vanderbilt.edu ) or Lauren P. Jackson ( lauren.p.jackson@vanderbilt.edu ) 16 8 2020 10 9 2020 14 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 coat proteins cryo-electron microscopy endosome trafficking Membrane...
Articles
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...-explored, how exactly does a single cell interpret a plethora of time-varying signals? Furthermore, how their subsequent responses at the single cell level manifest in the larger context of a developing tissue is unknown. At the same time, the biophysics and chemistry of how receptors are trafficked...
Articles
Biochem Soc Trans (2020) 48 (1): 83–93.
Published: 17 February 2020
... endowed with low and high affinity for ECM ligands. Increasing evidence proves that, differently to what hypothesized in the past, detachment from the ECM and conformational inactivation are not mandatory for integrin to get endocytosed and trafficked. Specific transmembrane and cytosolic proteins...
Articles
Biochem Soc Trans (2018) 46 (1): 43–50.
Published: 22 December 2017
... trafficking [Int. J. Mol. Sci. (2013) 14 , 18670–18681; Traffic (2000) 1 , 836–851]. How then does the cell organize this enormous transfer of material in its crowded internal environment? And how specifically do vesicles carrying proteins and lipids recognize and fuse with the correct compartment...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which...
Articles
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... through its Bin–Amphiphysin–Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent...
Articles
Biochem Soc Trans (2017) 45 (2): 489–497.
Published: 13 April 2017
..., CD81, and CD63 and their interaction partners in host cell entry by human cytomegalo- and human papillomaviruses. Moreover, we discuss a model for tetraspanin assembly into trafficking platforms at the plasma membrane. These platforms might persist during intracellular viral trafficking...
Articles
Biochem Soc Trans (2016) 44 (6): 1737–1744.
Published: 02 December 2016
... protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans , have revealed both that dimerization of this protein is essential for correct trafficking...
Articles
Biochem Soc Trans (2016) 44 (5): 1273–1280.
Published: 19 October 2016
... © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 cilia G-proteins trafficking Primary cilia are microtubule-based sensory organelles that emerge from centrioles and can be found on almost all human cell types as a single hair-like...
Articles
Biochem Soc Trans (2016) 44 (3): 891–897.
Published: 09 June 2016
... of MPRs [ 35 ]. Due to the large size of yeast and plant vacuoles, fluorescence microscopy has become the most widely used tool to study vacuolar trafficking. Despite a diversity of morphologies and numbers across kingdoms and cell types, lysosomes and vacuoles share a unique and common feature...
Articles
Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
...Heather Currinn; Thomas Wassmer Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking events. Due...
Articles
Biochem Soc Trans (2015) 43 (3): 508–512.
Published: 01 June 2015
... regulating the trafficking of the cardiac sodium channel Na V 1.5 to the membrane. 1 To whom correspondence should be addressed (email lwaring@sund.ku.dk ) . 25 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Cx43 intercalated disc microtubule Nav1.5...
Articles
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
..., distribution and reproduction in any medium, provided the original work is properly cited. calcium fission fusion gliotransmission mitophagy trafficking Astrocytes are a subset of glial cells that provide trophic and structural support for neurons. Accumulating evidence over the last few...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
...@qmul.ac.uk ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis cilium endothelial cell phosphatidylinositol 3-phosphate (PI3K) phosphoinositide 3-kinase (PI3K) trafficking Phosphoinositide 3-kinases (PI3Ks) are lipid kinases...
Articles
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
...Nicol Birsa; Rosalind Norkett; Nathalie Higgs; Guillermo Lopez-Domenech; Josef T. Kittler Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a precisely distributed and healthy mitochondrial...
Articles
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
...-lymphocyte glycolysis hypoxia-inducible factor 1α (HIF1α) mammalian target of rapamycin complex 1 (mTORC1) protein kinase B (PKB) trafficking mTOR (mammalian target of rapamycin) is a serine/threonine kinase with important functions for a range of cellular processes. mTOR forms two distinct...
Articles
Biochem Soc Trans (2013) 41 (1): 225–230.
Published: 29 January 2013
... receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4) J. Biol. Chem 2012 287 16656 16669 36 Zhong X. Kriz R. Seehra J. Kumar R. N-linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding...
Articles
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... and trafficking of GPCRs at the plasma membrane [ 13 ] ( Figure 2 ). Many activated receptors undergo rapid serine/threonine phosphorylation by G-protein receptor kinases. Phosphorylation serves to increase the affinity of receptors for β-arrestins, which translocate from the cytosol to interact with receptors...
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Biochem Soc Trans (2012) 40 (6): 1409–1415.
Published: 21 November 2012
... of the Rab11 pathway in the trafficking, assembly and budding steps of these viruses. assembly budding Rab11 recycling trafficking virus The Rab family of GTPases play crucial roles in directing cellular vesicular transport throughout the endosomal system, as individual Rab proteins serve...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... have demonstrated the essential role of these proteins in lysosomal acidification, transport of metabolites resulting from hydrolytic degradation and interaction and fusion with other cellular membrane systems. In addition, trafficking pathways of lysosomal membrane proteins are closely linked...
Articles
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
..., membrane-associated tau is dephosphorylated at serine/threonine residues, suggesting that the phosphorylation state of tau regulates its intracellular trafficking. Dephosphorylation of tau may increase the association of tau with trafficking proteins which target tau to the plasma membrane. Thus...
Articles
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
...Jonathan G. Hanley An important mechanism for the regulation of excitatory synaptic transmission in the hippocampus involves tight control of AMPAR [AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor] trafficking to alter the number or subtype of synaptic receptors...
Articles
Biochem Soc Trans (2010) 38 (2): 525–528.
Published: 22 March 2010
... ]. This increase intensified over days following ligation (experimental time points were 2, 4 and 7 days post-SNL). Within the dorsal roots, α 2 δ-1 was localized to tubular-vesicular structures that are implicated in protein trafficking [ 11 ]. A subset of DRG neurons involved in touch and proprioception do...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...). In addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic...
Articles
Biochem Soc Trans (2007) 35 (5): 1069–1073.
Published: 25 October 2007
...D.F. Steele; A. Dehghani Zadeh; M.E. Loewen; D. Fedida The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve...
Articles
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
..., it has been shown that disease pathogenesis in LQT1 can be influenced by the abnormal trafficking of KCNQ1. In comparison, whether defective trafficking of KCNE1 plays a role in LQT5 is less well established. 1 To whom correspondence should be addressed (email a.tinker@ucl.ac.uk ). 5 7...
Articles
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
... drugs. 1 email s.m.mizielinska@dundee.ac.uk 24 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 action potential antiepileptic drug epilepsy mutation ion channel neuronal excitability trafficking Epilepsy is one of the most common...
Articles
Biochem Soc Trans (2007) 35 (5): 1060–1063.
Published: 25 October 2007
... but by inhibition of hERG/ I Kr trafficking to the cell surface. Important examples are antineoplastic Hsp90 (heat-shock protein 90) inhibitors such as (i) geldanamycin, (ii) the leukaemia drug arsenic trioxide, (iii) the antiprotozoical pentamidine, (iv) probucol, a cholesterol-lowering drug, and (v) fluoxetine...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... trafficking in macrophages. 1 To whom correspondence should be addressed (email bart.staels@pasteur-lille.fr ). 25 7 2006 © 2006 The Biochemical Society 2006 cholesterol liver X receptor (LXR) macrophage peroxisome-proliferator-activated receptor α (PPARα) trafficking...
Articles
Biochem Soc Trans (2006) 34 (5): 877–881.
Published: 25 October 2006
...F.A. Stephenson The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABA A (γ-aminobutyric acid type...
Articles
Biochem Soc Trans (2006) 34 (1): 48–50.
Published: 20 January 2006
...K. Pozo; F.A. Stephenson GRIF-1 [GABA A (γ-aminobutyric acid A ) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail...
Articles
Biochem Soc Trans (2004) 32 (6): 1040–1044.
Published: 26 October 2004
... of small G-proteins with GPCRs and GPCR-regulatory proteins may influence GPCR signalling and intracellular trafficking. © 2004 The Biochemical Society 2004 cell signalling endocytosis G-protein-coupled receptor small G-protein trafficking Heterotrimeric GPCRs (G-protein-coupled...
Articles
Biochem Soc Trans (2004) 32 (1): 1–14.
Published: 01 February 2004
... and function, are trafficked to their required destination. Endocytosis plays, therefore, an important role in cell signalling, nutrient uptake, cellular homoeostasis and the interaction of the cell with its external environment. The formation of clathrin-coated endocytic vesicles requires the complex...
Articles
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
... with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts...
Articles
Biochem Soc Trans (2003) 31 (4): 875–879.
Published: 01 August 2003
... April 2003 14 March 2003 © 2003 Biochemical Society 2003 channel assembly endoplasmic reticulum oligomerization signal surface expression trafficking type A γ-aminobutyric acid receptor (GABA A receptor) Abbreviations used: GABA A , γ-aminobutyric acid type A; γ2L...
Articles
Biochem Soc Trans (2001) 29 (4): 500–504.
Published: 01 August 2001
... carriers and membrane pathways that mediate the endocytic trafficking of specific GPCRs. Insights into the biochemical and functional properties of endocytic vesicles containing internalized opioid and adrenergic receptors will be discussed. Progress towards understanding the mechanisms that control...