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Keywords: trafficking
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Articles
Biochem Soc Trans (2023) BST20220827.
Published: 11 January 2023
... scaling. The different AMPA receptor subunits (GluA1–GluA4) share a common modular structure and membrane topology, and their intracellular C-terminus tail is responsible for the interaction with intracellular proteins important in receptor trafficking. The latter sequence differs between subunits...
Articles
Biochem Soc Trans (2021) 49 (1): 507–517.
Published: 22 February 2021
...-endothelial trafficking of these substrates, may in fact be an early contributor towards the establishment of metabolic dysfunction and subsequent cardiovascular disease. Understanding the molecular mechanisms that underpin substrate trafficking through the endothelium represents an important area within...
Articles
Biochem Soc Trans (2021) 49 (1): 379–391.
Published: 22 February 2021
.../dephosphorylation protein–protein interactions trafficking Cellulose provides a potentially almost inexhaustible source of renewable carbon. Due to its high strength and stiffness, cellulose is a good candidate for producing biodegradable, non-toxic and high-strength materials at low cost [ 1 ]. Cellulose...
Articles
Biochem Soc Trans (2021) 49 (1): 467–476.
Published: 05 February 2021
... (Hh), the precise, cell cycle dependent orchestration of the MAPK-pathway appears to relay Ras activation in this context. We will examine how non-canonical activities of K-Ras4B (hereafter K-Ras) could be enabled by its trafficking chaperones calmodulin and PDE6D/PDEδ. Both dynamically localize...
Articles
Biochem Soc Trans (2020) 48 (6): 2721–2728.
Published: 18 December 2020
...Agata Nawrotek; Mahel Zeghouf; Jacqueline Cherfils Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties...
Articles
Biochem Soc Trans (2020) 48 (5): 2261–2272.
Published: 14 October 2020
...@vanderbilt.edu ) or Lauren P. Jackson ( lauren.p.jackson@vanderbilt.edu ) 16 8 2020 10 9 2020 14 9 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Figure 1. Overview of metazoan retromer-mediated trafficking pathways...
Articles
Biochem Soc Trans (2020) 48 (5): 2051–2066.
Published: 11 September 2020
...-explored, how exactly does a single cell interpret a plethora of time-varying signals? Furthermore, how their subsequent responses at the single cell level manifest in the larger context of a developing tissue is unknown. At the same time, the biophysics and chemistry of how receptors are trafficked...
Articles
Biochem Soc Trans (2020) 48 (1): 83–93.
Published: 17 February 2020
... endowed with low and high affinity for ECM ligands. Increasing evidence proves that, differently to what hypothesized in the past, detachment from the ECM and conformational inactivation are not mandatory for integrin to get endocytosed and trafficked. Specific transmembrane and cytosolic proteins...
Articles
Biochem Soc Trans (2018) 46 (1): 43–50.
Published: 22 December 2017
... trafficking [Int. J. Mol. Sci. (2013) 14 , 18670–18681; Traffic (2000) 1 , 836–851]. How then does the cell organize this enormous transfer of material in its crowded internal environment? And how specifically do vesicles carrying proteins and lipids recognize and fuse with the correct compartment...
Articles
Biochem Soc Trans (2017) 45 (6): 1323–1331.
Published: 17 November 2017
... to be associated with canonical membrane trafficking, but several mechanistic details are still missing. In this review, the current understanding and potential mechanisms by which membrane trafficking participates in macroautophagy are described, with a focus on the enigma of the membrane protein Atg9, for which...
Articles
Biochem Soc Trans (2017) 45 (3): 771–779.
Published: 15 June 2017
... through its Bin–Amphiphysin–Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent...
Articles
Biochem Soc Trans (2017) 45 (2): 489–497.
Published: 13 April 2017
..., CD81, and CD63 and their interaction partners in host cell entry by human cytomegalo- and human papillomaviruses. Moreover, we discuss a model for tetraspanin assembly into trafficking platforms at the plasma membrane. These platforms might persist during intracellular viral trafficking. © 2017...
Articles
Biochem Soc Trans (2016) 44 (6): 1737–1744.
Published: 02 December 2016
... protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans , have revealed both that dimerization of this protein is essential for correct trafficking...
Articles
Biochem Soc Trans (2016) 44 (5): 1273–1280.
Published: 19 October 2016
... and PDE6D. In addition to its ciliary function, PDE6D is involved in trafficking of non-ciliary proteins as well. Knocking down PDE6D in pancreatic cancer cell lines resulted in mislocalisation of prenylated Ras from plasma membrane to endomembranes and the attenuation of its oncogenic signalling [ 20...
Articles
Biochem Soc Trans (2016) 44 (3): 891–897.
Published: 09 June 2016
...-terminal tail which contains signals for trafficking of the receptor. The N-terminal domain represents the region that is mostly different between receptors among different kingdoms, probably due to the variety of lysosomal/vacuolar proteins to be recognized. Receptors can be classified in four families...
Articles
Biochem Soc Trans (2016) 44 (1): 185–190.
Published: 09 February 2016
...Heather Currinn; Thomas Wassmer Phosphoinositides are important components of eukaryotic membranes that are required for multiple forms of membrane dynamics. Phosphoinositides are involved in defining membrane identity, mediate cell signalling and control membrane trafficking events. Due...
Articles
Biochem Soc Trans (2015) 43 (3): 508–512.
Published: 01 June 2015
... regulating the trafficking of the cardiac sodium channel Na V 1.5 to the membrane. 1 To whom correspondence should be addressed (email lwaring@sund.ku.dk ) . 25 2 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 Cx43 intercalated disc microtubule Nav1.5...
Articles
Biochem Soc Trans (2014) 42 (5): 1378–1382.
Published: 18 September 2014
...@qmul.ac.uk ) . 14 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis cilium endothelial cell phosphatidylinositol 3-phosphate (PI3K) phosphoinositide 3-kinase (PI3K) trafficking Phosphoinositide 3-kinases (PI3Ks) are lipid kinases...
Articles
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
..., distribution and reproduction in any medium, provided the original work is properly cited. calcium fission fusion gliotransmission mitophagy trafficking Astrocytes are a subset of glial cells that provide trophic and structural support for neurons. Accumulating evidence over the last few...
Articles
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
...Nicol Birsa; Rosalind Norkett; Nathalie Higgs; Guillermo Lopez-Domenech; Josef T. Kittler Correct mitochondrial dynamics are essential to neuronal function. These dynamics include mitochondrial trafficking and quality-control systems that maintain a precisely distributed and healthy mitochondrial...
Articles
Biochem Soc Trans (2013) 41 (2): 681–686.
Published: 21 March 2013
...-lymphocyte glycolysis hypoxia-inducible factor 1α (HIF1α) mammalian target of rapamycin complex 1 (mTORC1) protein kinase B (PKB) trafficking mTOR (mammalian target of rapamycin) is a serine/threonine kinase with important functions for a range of cellular processes. mTOR forms two distinct...
Articles
Biochem Soc Trans (2013) 41 (1): 225–230.
Published: 29 January 2013
... should be addressed (email s.j.mundell@bris.ac.uk ). 30 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 GPCR (G-protein-coupled receptor) motif P2Y 12 platelets trafficking variants P2Y receptors are a superfamily of GPCRs (G-protein-coupled...
Articles
Biochem Soc Trans (2013) 41 (1): 137–143.
Published: 29 January 2013
... trafficking With almost 1000 members, the heptahelical GPCRs (G-protein-coupled receptors) comprise the largest family of cell-surface receptors. They allow cells to detect and respond to extraordinarily diverse environmental and endogenous stimuli, and they participate in most aspects...
Articles
Biochem Soc Trans (2013) 41 (1): 79–83.
Published: 29 January 2013
... Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization...
Articles
Biochem Soc Trans (2012) 40 (6): 1409–1415.
Published: 21 November 2012
... of the Rab11 pathway in the trafficking, assembly and budding steps of these viruses. 1 To whom correspondence should be addressed (email embruce@gmail.com ). 10 7 2012 © 2012 The Authors Journal 2012 assembly budding Rab11 recycling trafficking virus The Rab family...
Articles
Biochem Soc Trans (2010) 38 (6): 1420–1423.
Published: 24 November 2010
... have demonstrated the essential role of these proteins in lysosomal acidification, transport of metabolites resulting from hydrolytic degradation and interaction and fusion with other cellular membrane systems. In addition, trafficking pathways of lysosomal membrane proteins are closely linked...
Articles
Biochem Soc Trans (2010) 38 (4): 1012–1015.
Published: 26 July 2010
..., membrane-associated tau is dephosphorylated at serine/threonine residues, suggesting that the phosphorylation state of tau regulates its intracellular trafficking. Dephosphorylation of tau may increase the association of tau with trafficking proteins which target tau to the plasma membrane. Thus...
Articles
Biochem Soc Trans (2010) 38 (2): 460–465.
Published: 22 March 2010
...Jonathan G. Hanley An important mechanism for the regulation of excitatory synaptic transmission in the hippocampus involves tight control of AMPAR [AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor] trafficking to alter the number or subtype of synaptic receptors...
Articles
Biochem Soc Trans (2010) 38 (2): 525–528.
Published: 22 March 2010
... α 2 δ-1 neuropathic pain pregabalin spinal nerve ligation trafficking voltage-gated calcium channel Unlike nociceptive or acute pain, neuropathic pain occurs without continuous noxious peripheral input. Patients with neuropathic pain experience spontaneous pain that is described...
Articles
Biochem Soc Trans (2009) 37 (6): 1364–1368.
Published: 19 November 2009
...). In addition, leptin promotes rapid alterations in hippocampal dendritic morphology and synaptic density, which are likely to contribute to the effects of this hormone on excitatory synaptic strength. Recent studies have demonstrated that trafficking of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic...
Articles
Biochem Soc Trans (2007) 35 (5): 1060–1063.
Published: 25 October 2007
... but by inhibition of hERG/ I Kr trafficking to the cell surface. Important examples are antineoplastic Hsp90 (heat-shock protein 90) inhibitors such as (i) geldanamycin, (ii) the leukaemia drug arsenic trioxide, (iii) the antiprotozoical pentamidine, (iv) probucol, a cholesterol-lowering drug, and (v) fluoxetine...
Articles
Biochem Soc Trans (2007) 35 (5): 1069–1073.
Published: 25 October 2007
...D.F. Steele; A. Dehghani Zadeh; M.E. Loewen; D. Fedida The proper trafficking and localization of cardiac potassium channels is profoundly important to the regulation of the regionally distinct action potentials across the myocardium. These processes are only beginning to be unravelled and involve...
Articles
Biochem Soc Trans (2007) 35 (5): 1074–1076.
Published: 25 October 2007
..., it has been shown that disease pathogenesis in LQT1 can be influenced by the abnormal trafficking of KCNQ1. In comparison, whether defective trafficking of KCNE1 plays a role in LQT5 is less well established. Figure 1 Topology of the α-, KCNQ1, and β-, KCNE1, subunits that complex to form...
Articles
Biochem Soc Trans (2007) 35 (5): 1077–1079.
Published: 25 October 2007
... drugs. action potential antiepileptic drug epilepsy mutation ion channel neuronal excitability trafficking Epilepsy is one of the most common neurological disorders affecting 2% of the worlD's population. It varies widely in type and severity of seizures and should not be considered...
Articles
Biochem Soc Trans (2006) 34 (5): 877–881.
Published: 25 October 2006
...F.A. Stephenson The fidelity of synaptic function is dependent on the expression of the appropriate neurotransmitter receptor subtype, the targeting and trafficking of receptors to synapses as well as the regulation of the actual number of receptors at synapses. GABA A (γ-aminobutyric acid type...
Articles
Biochem Soc Trans (2006) 34 (6): 1128–1131.
Published: 25 October 2006
... trafficking in macrophages. The LXRs (LXRα and LXRβ) are nuclear receptors activated by oxysterols that play a central role in the transcriptional control of lipid metabolism [ 5 ]. LXRα is expressed highly in the liver and at lower levels in the adrenal glands, intestine, adipose tissue, macrophages, lung...
Articles
Biochem Soc Trans (2006) 34 (1): 48–50.
Published: 20 January 2006
...K. Pozo; F.A. Stephenson GRIF-1 [GABA A (γ-aminobutyric acid A ) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail...
Articles
Biochem Soc Trans (2004) 32 (6): 1040–1044.
Published: 26 October 2004
... of small G-proteins with GPCRs and GPCR-regulatory proteins may influence GPCR signalling and intracellular trafficking. 1 To whom correspondence should be addressed, at Cell Biology Research Group, Robarts Research Institute (email ferguson@robarts.ca ). 21 6 2004 © 2004...
Articles
Biochem Soc Trans (2004) 32 (1): 1–14.
Published: 01 February 2004
... and function, are trafficked to their required destination. Endocytosis plays, therefore, an important role in cell signalling, nutrient uptake, cellular homoeostasis and the interaction of the cell with its external environment. The formation of clathrin-coated endocytic vesicles requires the complex...
Articles
Biochem Soc Trans (2003) 31 (4): 885–888.
Published: 01 August 2003
... with respect to its physiology and pharmacology, its cell-biological properties, such as subunit assembly, post-translational processing and trafficking in neurons, are only beginning to be addressed. Critical to many of the functions of the NMDA receptor are the multiple proteins with which it interacts...
Articles
Biochem Soc Trans (2003) 31 (4): 875–879.
Published: 01 August 2003
... Biochemical Society 2003 channel assembly endoplasmic reticulum oligomerization signal surface expression trafficking type A γ-aminobutyric acid receptor (GABA A receptor) Abbreviations used: GABA A , γ-aminobutyric acid type A; γ2L, γ2Long; γ2S, γ2Short; ER, endoplasmic reticulum; BiP...
Articles
Biochem Soc Trans (2001) 29 (4): 500–504.
Published: 01 August 2001
... carriers and membrane pathways that mediate the endocytic trafficking of specific GPCRs. Insights into the biochemical and functional properties of endocytic vesicles containing internalized opioid and adrenergic receptors will be discussed. Progress towards understanding the mechanisms that control...