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Biochem Soc Trans (2016) 44 (2): 406–411.
Published: 11 April 2016
... antigens (TAAs) has been limited by organ toxicities related to activation of T-cell effector functions through the CAR. Most existing CARs recognize TAAs, which are also found in normal tissues. CAR-T-cell-mediated destruction of normal tissues constitutes a major roadblock to CAR-T-cell therapy, and must...
Biochem Soc Trans (2015) 43 (4): 657–662.
Published: 03 August 2015
... that are likely to provoke toxicity in humans. Mammalian cells can adapt to chemical and oxidative stress via the action of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which up-regulates the expression of numerous cell defence genes and has been shown to protect against a variety...
Biochem Soc Trans (2010) 38 (4): 996–1000.
Published: 26 July 2010
... of mutant tau leads to NFT formation, synaptic loss and neuronal death in several models. The association between neuronal death and NFTs has, however, been challenged in some models showing a dissociation between tau aggregation and tau toxicity. Cross-breeding of mice developing NFTs with mice developing...
Biochem Soc Trans (2007) 35 (4): 821–825.
Published: 20 July 2007
... 2007 Biochemical Society 2007 cell-penetrating peptide cell penetration drug development intracellular target pharmacokinetics toxicity Additional studies of tissue distribution, clearance metabolism and pharmacokinetics of CPP-conjugated compounds will better characterize...
H.M. Moulton, S. Fletcher, B.W. Neuman, G. McClorey, D.A. Stein, S. Abes, S.D. Wilton, M.J. Buchmeier, B. Lebleu, P.L. Iversen
Biochem Soc Trans (2007) 35 (4): 826–828.
Published: 20 July 2007
.... Peptide-related toxicity was not observed in the 5 mg/kg dose regime [ 6 ]. Absence of exon skipping in the heart is a concern for the therapeutic use of the conjugate. Application of the PPMO to neonatal mdx cardiomyocytes ex vivo induced pronounced exon 23 skipping ( Figure 1 ), suggesting in vivo...
Biochem Soc Trans (2001) 29 (6): 831–835.
Published: 01 November 2001
... (SPT) and the availability of its substrates (especially palmitoyl-CoA) can have toxic consequences for cells by increasing the production of cytotoxic intermediates. Recent work has also revealed that diverse agonists and stresses (cytokines, UV light, glucocorticoids, heat shock and toxic compounds...