... antigens (TAAs) has been limited by organ toxicities related to activation of T-cell effector functions through the CAR. Most existing CARs recognize TAAs, which are also found in normal tissues. CAR-T-cell-mediated destruction of normal tissues constitutes a major roadblock to CAR-T-cell therapy, and must...

... that are likely to provoke toxicity in humans. Mammalian cells can adapt to chemical and oxidative stress via the action of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which up-regulates the expression of numerous cell defence genes and has been shown to protect against a variety...

... of mutant tau leads to NFT formation, synaptic loss and neuronal death in several models. The association between neuronal death and NFTs has, however, been challenged in some models showing a dissociation between tau aggregation and tau toxicity. Cross-breeding of mice developing NFTs with mice developing...

... CPPs across multiple therapeutic approaches. Safety of CPPs is critical to developing a wider use of these domains for drug development. A few studies have examined the cellular cytotoxicity of CPPs [ 13 , 14 , 42 ]. Fewer studies have reported in vivo toxicity with CPPs [ 43 , 44 ]. Two...

.... 1 To whom correspondence should be addressed (email moulton@avibio.com ). 18 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell-penetrating peptide (CPP) Duchenne muscular dystrophy (DMD) exon skipping morpholino poly-arginine toxicity...

... (SPT) and the availability of its substrates (especially palmitoyl-CoA) can have toxic consequences for cells by increasing the production of cytotoxic intermediates. Recent work has also revealed that diverse agonists and stresses (cytokines, UV light, glucocorticoids, heat shock and toxic compounds...