... for optimal immune tolerance and a partial failure to tolerize is linked to the autoimmune responses to insulin and other β-cell proteins that precede T1DM onset. Gene variants that contribute to common disease susceptibility often alter gene expression only modestly. Small expression changes can...

...S.L. Stevens; M.P. Stenzel-Poore Ischaemic tolerance in the brain is a powerful adaptive defence that involves an endogenous programme of neuroprotection culminating in marked protection against brain injury from ischaemia. A range of preconditioning stimuli exist that differ in ligand and target...