.... The development of drugs that target PARs has been the focus of many laboratories for the potential treatment of thrombosis, cancer and other inflammatory diseases. Understanding the mechanisms of PAR activation and G protein signalling pathways evoked in response to the growing list of endogenous proteases has...

... platelets reach as forerunners and function as critical players. 1 To whom correspondence should be addressed (email meinrad.gawaz@med.uni-tuebingen.de ) . 12 5 2015 New Perspectives in Thrombosis, Haemostasis and Vascular Biology: Held at University College Dublin, Ireland, 13–14...

...Sakthivel Vaiyapuri; Gagan D. Flora; Jonathan M. Gibbins Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischaemic stroke. Although platelets circulate in isolation, upon activation...

... compilation © 2008 Biochemical Society 2008 cell adhesion integrin Rap1 signal transduction talin thrombosis Figure 2 Connecting agonist stimulation to integrin activation Depicted are core connections between agonists and integrins. Agonist receptors (e.g. G-protein-coupled receptors...

.... (email Charles-esmon@omrf.ouhsc.edu ). 17 9 2004 © 2005 The Biochemical Society 2005 blood coagulation endothelial cell protein C receptor inflammation protein C sepsis thrombosis Inflammatory mediators trigger the coagulation response in a number of ways: they induce...

... action of thrombin. (i) Exposure of endothelial cells to thrombin cause a time- and dose-dependent decrease in the attachment of these cells to basement membrane components, ~ ~~ Key words: integrin, thrombosis, tumour. Abbreviations used: CAM, chick chorioallantoic membrane; cRGD, cycled Arg-Gly-Asp-D...