... on the significant immunoregulatory role of SEMA4D and the associated underlying mechanisms, as well as the potential application of SEMA4D as a diagnostic marker and therapeutic target for the treatment of immunological diseases. Correspondence: Dongzhe Song ( dongzhesong@scu.edu.cn ) or Dingming Huang...

... propose that copper-binding and/or -chaperoning proteins, especially MTs, are potential therapeutic targets for HD. 1 To whom correspondence should be addressed (email aw3@soton.ac.uk ). 28 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Cell lysis...

... is implicating serine proteases within apoptotic processing, particularly in the generation of nuclear events such as condensation, fragmentation and DNA degradation observed in late-stage apoptosis. Serine proteases therefore are emerging as providing additional or alternative therapeutic targets...

... apoptosis hsp molecular chaperone motoneuron therapeutic target Neurodegenerative diseases are characterized by changes in protein structure, which result in misfolding and aggregation. Molecular chaperones such as hsps (heat-shock proteins) are thought to play a critical role in preventing...