... on the significant immunoregulatory role of SEMA4D and the associated underlying mechanisms, as well as the potential application of SEMA4D as a diagnostic marker and therapeutic target for the treatment of immunological diseases. Correspondence: Dongzhe Song ( dongzhesong@scu.edu.cn ) or Dingming Huang...

... propose that copper-binding and/or -chaperoning proteins, especially MTs, are potential therapeutic targets for HD. 1 To whom correspondence should be addressed (email aw3@soton.ac.uk ). 28 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 copper...

... is implicating serine proteases within apoptotic processing, particularly in the generation of nuclear events such as condensation, fragmentation and DNA degradation observed in late-stage apoptosis. Serine proteases therefore are emerging as providing additional or alternative therapeutic targets. AP24...

... been shown to act as negative regulators of the apoptotic cascade [ 3 ]. Thus hsps have a dual functionality and can act both as modulators of survival and death-signalling pathways and as protein chaperones. They are therefore an attractive choice for therapeutic targeting in neurodegenerative...