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Keywords: targeted therapy
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Biochem Soc Trans (2021) 49 (2): 843–854.
Published: 11 March 2021
... performance of currently approved anti-cancer targeted agents. In this review, we highlight the impact of glycosylation in cancer targeted therapy, with particular focus on receptor tyrosine kinase-targeted therapy, immune checkpoints blockade therapy, and current developments on therapeutic strategies...
Biochem Soc Trans (2020) 48 (4): 1623–1636.
Published: 06 July 2020
... level, genetic factors and bad hobbies. At the same time, the occurrence of the OP and its complications has different degrees of impact on people's quality of life. Based on the current understanding of the OP, we summarized the etiology, current clinical drugs and potential targeting therapy for OP...
Biochem Soc Trans (2014) 42 (4): 733–741.
Published: 11 August 2014
... are in clinical trials. Unfortunately, current therapies for advanced cancers that target PI3K often lead to the development of resistance and relapse of the disease. It is therefore important to establish the molecular mechanisms of resistance to PI3K-targeted therapy. With the focus on breast cancer...
Biochem Soc Trans (2014) 42 (4): 752–757.
Published: 11 August 2014
...) p53 mutation targeted therapy Despite continuous progress, many types of cancer cannot be treated successfully. In particular, the prognosis for patients who are diagnosed with metastasized cancer disease remains unacceptably poor. Acquisition of resistance to anti-cancer therapies remains...
Biochem Soc Trans (2014) 42 (4): 765–769.
Published: 11 August 2014
... correspondence should be addressed (email glj@med.unc.edu ). 17 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 adaptive resistance cancer kinase inhibitor kinome targeted therapy Studies both in cell culture and in patients have identified predominant...
Biochem Soc Trans (2011) 39 (2): 451–455.
Published: 22 March 2011
... in cancer patients. 1 email echeverria@sanofi-aventis.com 25 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer mammalian target of rapamycin inhibitor (mTOR inhibitor) phosphoinositide 3-kinase (PI3K) rapalogue targeted therapy...
Biochem Soc Trans (2007) 35 (4): 780–783.
Published: 20 July 2007
... which are capable of targeting and internalization (homing and cell uptake via a recognition molecule, useful for targeted therapies or imaging purposes when conjugated to a drug/detectable label). (3) Peptides which are capable of targeting, internalization and destruction (all performed...