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Keywords: systems biology
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Biochem Soc Trans (2023) 51 (1): 13–20.
Published: 23 January 2023
... of Cambridge in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. biological networks cellular localization drug discovery and design G-protein-coupled receptors signalling systems biology GPCR...
Articles
Biochem Soc Trans (2021) 49 (1): 41–54.
Published: 05 February 2021
... [ 12 , 15–17 ] relying e.g. on absolute quantitative data. Given the complexity and diversity of the questions that are addressed by systems biology and medicine, there is no single correct approach to a given problem. Yet, conventions arise for certain problems and the call for standardization becomes...
Articles
Biochem Soc Trans (2020) 48 (4): 1309–1321.
Published: 29 July 2020
... model guided systems biology approaches where genome scale metabolic models (GEMs) can be used to describe their cellular behaviors and metabolic states of probiotic strains under various gut environments. Here, we summarize currently available GEMs of microbial strains with probiotic potentials...
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Biochem Soc Trans (2020) 48 (3): 955–969.
Published: 05 May 2020
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cancer drug repurposing drug target discovery metabolic modelling personalized medicine systems biology Since Otto Warburg, it is known that some cancer...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (4): 1015–1024.
Published: 21 July 2017
... 12 2016 23 4 2017 25 5 2017 complexl network quasi-sequential optimization approach state transition systems biology Cancer is an important disease that seriously threatens human life. Traditional methods for developing cancer treatments include searching for reliable...
Articles
Biochem Soc Trans (2017) 45 (3): 635–652.
Published: 15 June 2017
...Abulikemu Abudukelimu; Thierry D.G.A. Mondeel; Matteo Barberis; Hans V. Westerhoff We present a systems biology view on pseudoenzymes that acknowledges that genes are not selfish: the genome is. With network function as the selectable unit, there has been an evolutionary bonus for recombination...
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Biochem Soc Trans (2016) 44 (3): 731–737.
Published: 09 June 2016
... modelling promoter synthetic biology systems biology Predictable output is a defining aspiration of synthetic biology. A number of factors affect the output from synthetic gene networks to a greater or lesser extent, including transgene copy number [ 1 ], integration into the genome or expression...
Articles
Biochem Soc Trans (2014) 42 (4): 791–797.
Published: 11 August 2014
... for Activiomics Ltd. 2 To whom correspondence should be addressed (email p.cutillas@qmul.ac.uk ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acquired resistance cancer mass spectrometry phosphoproteomics signalling plasticity systems biology...
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Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
... control is emphasized by the interdisciplinary research approaches required to address this area with speakers highlighting emerging systems biology techniques and their application to understanding mRNA translation and the network of pathways controlling it. Whether it is the rate-limiting step...
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Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology In summary, in the present article...
Articles
Biochem Soc Trans (2013) 41 (6): 1736–1744.
Published: 20 November 2013
... systems biology Severing factors (katanin and spastin [ 30 – 32 ]) commonly destabilize microtubules by cutting microtubules in the middle of the lattice, creating two new microtubule ends. In vitro , this induces rapid catastrophe of the newly created plus end, lacking a GTP-cap, usually...
Articles
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...Xuan Liu; De-An Guo Systems biology is considered to be the possible technology that could bring breakthroughs in the study of TCM (traditional Chinese medicine). Proteomics, as one of the major components of systems biology, has been used in the mechanistic study of TCM, providing some interesting...
Articles
Biochem Soc Trans (2010) 38 (5): 1329–1332.
Published: 24 September 2010
...) systems biology Toll-like receptor 4 (TLR4) The field of glycobiology is currently expanding rapidly and attracting interest due to an increasing awareness of its immediate wide-ranging relevance [ 1 ]. Glycans decorate the surfaces of proteins and cells and occupy substantial proportions...
Articles
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
.... Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental...
Articles
Biochem Soc Trans (2010) 38 (5): 1374–1377.
Published: 24 September 2010
... relationship with other biological disciplines in a systems biology approach. 1 These authors contributed equally to the paper . 2 To whom correspondence should be addressed (email pauline.rudd@nibrt.ie ). 28 4 2010 © The Authors Journal compilation © 2010 Biochemical...
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Biochem Soc Trans (2010) 38 (5): 1265–1269.
Published: 24 September 2010
... systems engineering. 1 To whom correspondence should be addressed (email mark.roberts@bioch.ox.ac.uk ). 6 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 bacterium chemotaxis flagellum methyl-accepting chemotaxis protein (MCP) swimming systems...
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Biochem Soc Trans (2010) 38 (5): 1356–1360.
Published: 24 September 2010
... requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other ‘-omics’ approaches to define...
Articles
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Published: 24 September 2010
... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...
Articles
Biochem Soc Trans (2010) 38 (5): 1302–1306.
Published: 24 September 2010
... Catalunya, [grant numbers 2009SGR1308, 2006ITT-10007]. References 1 Kitano H. Foundations of Systems Biology 2001 Cambridge, MA MIT Press 2 Oliver S.G. Winson M.K. Kell D.B. Baganz F. Systematic functional analysis of the yeast genome Trends Biotechnol. 1998 16...
Articles
Biochem Soc Trans (2010) 38 (5): 1275–1280.
Published: 24 September 2010
... G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...
Articles
Biochem Soc Trans (2010) 38 (5): 1189–1196.
Published: 24 September 2010
... is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come...
Articles
Biochem Soc Trans (2009) 37 (1): 58–64.
Published: 20 January 2009
...; Hans V. Westerhoff; Patricia Wieloch; Phillip C. Wright; Melanie Zaparty SulfoSYS ( Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism) of Sulfolobus solfataricus and its regulation under temperature variation at the systems level. In Archaea, carbohydrates...
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Biochem Soc Trans (2008) 36 (1): 51–54.
Published: 22 January 2008
... mathematical models of biochemical pathways in systems biology. 1 To whom correspondence should be addressed (email matthias.stein@eml-r.villa-bosch.de ). 14 9 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 computational approach enzymatic kinetic parameters...
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Biochem Soc Trans (2005) 33 (6): 1427–1429.
Published: 26 October 2005
... an important method to study data analysis algorithms in systems biology. This approach is expected to be particularly important in comparing competing data analysis methods that require considerably different experimental setups. In that case, modelling may be the only way to be able to study...
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Biochem Soc Trans (2005) 33 (3): 503–506.
Published: 01 June 2005
...M.P. Williamson Systems biology describes the collection of a set of measurements on a system, integrated with a mathematical model of that system. The model and the measurements must be made together and refined iteratively, requiring close collaboration between biologists and modellers...
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Biochem Soc Trans (2005) 33 (3): 539–542.
Published: 01 June 2005
... systems. I use models of the heart to demonstrate that we can now go all the way from individual genetic information (on mutations, for example) to exploring the consequences at a whole-organ level. Yes, let's celebrate the emergence of Systems Biology as a discipline. The challenge posed...
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Biochem Soc Trans (2005) 33 (3): 516–519.
Published: 01 June 2005
...A. Cornish-Bowden; M.L. Cárdenas The first point to note about whether systems biology will work is that the essential idea of systems biology is not new: there has been interest in it, as well as efforts to apply it, since the middle of the 20th century. The difference now is that it has become...
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Biochem Soc Trans (2005) 33 (3): 520–524.
Published: 01 June 2005
...D.B. Kell In answering the question ‘Systems Biology – will it work?’ (which it self-evidently has already), it is appropriate to highlight advances in philosophy, in new technique development and in novel findings. In terms of philosophy, we see that systems biology involves an iterative interplay...
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Biochem Soc Trans (2005) 33 (3): 507–515.
Published: 01 June 2005
...O. Wolkenhauer; S.N. Sreenath; P. Wellstead; M. Ullah; K.-H. Cho A mathematical understanding of regulation, and, in particular, the role of feedback, has been central to the advance of the physical sciences and technology. In this article, the framework provided by systems biology is used to argue...
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Biochem Soc Trans (2003) 31 (6): 1513–1515.
Published: 01 December 2003
... biochemical network modelling Petri Net simulation systems biology Unravelling Nature s Networks 1513 Petri Net representations in systems biology J.W. Pinney1, D.R. Westhead and G.A. McConkey Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K. Abstract The mathematical structures...
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Biochem Soc Trans (2003) 31 (6): 1503–1509.
Published: 01 December 2003
... and physical sciences involved in life sciences. The emergence of systems biology as a new area of research is evidence for these developments. Dynamic modelling and simulation of signal transduction pathways is an important theme in systems biology and is getting growing attention from researchers...