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Keywords: systems biology
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Articles
Biochem Soc Trans (2021) 49 (1): 41–54.
Published: 05 February 2021
... by the phosphatases PHLPP1/2 (PH domain and leucine rich repeat protein phosphatase 1/2) [ 78 ] and/ or PP2A (protein phosphatase 2 A) [ 79 ]. amino acids computational models mechanistic target of rapamycin protein kinase B signaling systems biology Kinase signaling networks are a prime example...
Articles
Biochem Soc Trans (2020) 48 (4): 1309–1321.
Published: 29 July 2020
... model guided systems biology approaches where genome scale metabolic models (GEMs) can be used to describe their cellular behaviors and metabolic states of probiotic strains under various gut environments. Here, we summarize currently available GEMs of microbial strains with probiotic potentials...
Articles
Biochem Soc Trans (2020) 48 (3): 901–913.
Published: 07 May 2020
... in microbiotas according to expected metabolic phenotypes can be addressed with gap-filling problems. community selection gap-filling metabolic networks non-model organisms systems biology systems ecology Systems biology consists in considering an organism or an interacting group of organisms...
Articles
Biochem Soc Trans (2020) 48 (3): 955–969.
Published: 05 May 2020
... drug repurposing drug target discovery metabolic modelling personalized medicine systems biology Another hurdle that needs to be overcome is the intra-tumour heterogeneity. As tumours can be composed of different clones carrying different mutations, the reconstruction of models based...
Includes: Supplementary data
Articles
Biochem Soc Trans (2017) 45 (4): 1015–1024.
Published: 21 July 2017
... approach state transition systems biology Cancer is an important disease that seriously threatens human life. Traditional methods for developing cancer treatments include searching for reliable and efficient chemotherapy strategies in clinical trials. However, these trials are limited because...
Articles
Biochem Soc Trans (2017) 45 (3): 635–652.
Published: 15 June 2017
...Abulikemu Abudukelimu; Thierry D.G.A. Mondeel; Matteo Barberis; Hans V. Westerhoff We present a systems biology view on pseudoenzymes that acknowledges that genes are not selfish: the genome is. With network function as the selectable unit, there has been an evolutionary bonus for recombination...
Articles
Biochem Soc Trans (2016) 44 (3): 675–677.
Published: 09 June 2016
... 2016 The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biocatalysis fine chemicals metabolic engineering synthetic biology systems biology...
Articles
Biochem Soc Trans (2016) 44 (3): 731–737.
Published: 09 June 2016
...) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY-NC-ND) . artificial neural networks partial least squares modelling promoter synthetic biology systems...
Articles
Biochem Soc Trans (2014) 42 (4): 791–797.
Published: 11 August 2014
... for Activiomics Ltd. 2 To whom correspondence should be addressed (email p.cutillas@qmul.ac.uk ). 21 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 acquired resistance cancer mass spectrometry phosphoproteomics signalling plasticity systems biology...
Articles
Biochem Soc Trans (2014) 42 (1): 151–154.
Published: 23 January 2014
... control is emphasized by the interdisciplinary research approaches required to address this area with speakers highlighting emerging systems biology techniques and their application to understanding mRNA translation and the network of pathways controlling it. 1 To whom correspondence should...
Articles
Biochem Soc Trans (2014) 42 (1): 155–159.
Published: 23 January 2014
... to many other biological/medical questions/fields. 1 email tamirtul@post.tau.ac.il 12 6 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biological model codon bias gene expression gene translation systems biology Codon bias is defined...
Articles
Biochem Soc Trans (2013) 41 (6): 1736–1744.
Published: 20 November 2013
... be addressed (email cre20@cam.ac.uk ). 9 10 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 cytoskeleton microtubule post-genomic era systems biology The post-genomic era has greatly expanded our knowledge of biology and has generated a host of new fields...
Articles
Biochem Soc Trans (2011) 39 (5): 1348–1352.
Published: 21 September 2011
...Xuan Liu; De-An Guo Systems biology is considered to be the possible technology that could bring breakthroughs in the study of TCM (traditional Chinese medicine). Proteomics, as one of the major components of systems biology, has been used in the mechanistic study of TCM, providing some interesting...
Articles
Biochem Soc Trans (2010) 38 (5): 1189–1196.
Published: 24 September 2010
... is the jungle of interactions. Consequently, we need to find the Rosetta Stones, i.e. interpretations of this jungle of systems biology. We need to find, perhaps convoluted, paths of understanding and intervention. Systems biochemistry is a good place to start, as it has the foothold that what goes in must come...
Articles
Biochem Soc Trans (2010) 38 (5): 1329–1332.
Published: 24 September 2010
...) systems biology Toll-like receptor 4 (TLR4) The field of glycobiology is currently expanding rapidly and attracting interest due to an increasing awareness of its immediate wide-ranging relevance [ 1 ]. Glycans decorate the surfaces of proteins and cells and occupy substantial proportions...
Articles
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
.... Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental...
Articles
Biochem Soc Trans (2010) 38 (5): 1374–1377.
Published: 24 September 2010
... relationship with other biological disciplines in a systems biology approach. 1 These authors contributed equally to the paper . 2 To whom correspondence should be addressed (email pauline.rudd@nibrt.ie ). 28 4 2010 © The Authors Journal compilation © 2010 Biochemical...
Articles
Biochem Soc Trans (2010) 38 (5): 1265–1269.
Published: 24 September 2010
... bacterium chemotaxis flagellum methyl-accepting chemotaxis protein (MCP) swimming systems biology Figure 1 The chemotaxis system in E. coli A, CheA histidine protein kinase; W, CheW linker protein between receptors and CheA; Y, the response regulator CheY; B, the response regulator CheB; R...
Articles
Biochem Soc Trans (2010) 38 (5): 1356–1360.
Published: 24 September 2010
... requires the development of a holistic systems biology view of their structure and interactions. In the present paper, I describe some of the new tools available to realize this strategy, and discuss the future potential for the combined application of glycomics and other ‘-omics’ approaches to define...
Articles
Biochem Soc Trans (2010) 38 (5): 1319–1321.
Published: 24 September 2010
... adrenaline calcium Modular Control and Regulation Analysis non-invasive 31 P-NMR perfused heart systems biology Top-down or modular approaches to MCA (Metabolic Control Analysis) have been used by us and others to overcome the complexity of investigating intracellular and intra-organ regulation...
Articles
Biochem Soc Trans (2010) 38 (5): 1302–1306.
Published: 24 September 2010
... systems biology tumour metabolism Current high-throughput technologies are applied to examine the whole components of a cell. However, understanding the crucial cellular events such as differentiation, cell-cycle progression or apoptosis requires detailed knowledge not only of the components...
Articles
Biochem Soc Trans (2010) 38 (5): 1275–1280.
Published: 24 September 2010
... G-protein-coupled receptor (GPCR) kinetic modelling Leber congenital amaurosis phototransduction rod systems biology The primary events in vertebrate vision are the biochemical steps in the phototransduction cascade in rods and cones, the retinal photoreceptor cells. This signal...
Articles
Biochem Soc Trans (2009) 37 (1): 58–64.
Published: 20 January 2009
...; Hans V. Westerhoff; Patricia Wieloch; Phillip C. Wright; Melanie Zaparty SulfoSYS ( Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism) of Sulfolobus solfataricus and its regulation under temperature variation at the systems level. In Archaea, carbohydrates...
Articles
Biochem Soc Trans (2008) 36 (3): 321–327.
Published: 21 May 2008
... β-cells and the immune system, will require a systems biology approach to the problem. This will hopefully allow the search for a cure for T1DM to move from a ‘trial-and-error’ approach to one that is really mechanistically driven. 1 To whom correspondence should be addressed (email deizirik...
Articles
Biochem Soc Trans (2008) 36 (1): 51–54.
Published: 22 January 2008
... mathematical models of biochemical pathways in systems biology. 1 To whom correspondence should be addressed (email matthias.stein@eml-r.villa-bosch.de ). 14 9 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 computational approach enzymatic kinetic parameters...
Articles
Biochem Soc Trans (2007) 35 (5): 1306–1309.
Published: 25 October 2007
... 2007 Biochemical Society 2007 Affymetrix endurance exercise integrin microRNA non-coding RNA systems biology Regular physical training improves insulin-sensitivity and vascular function of skeletal muscle [ 1 ]. Lack of cardiorespiratory (aerobic) capacity and low habitual physical...
Articles
Biochem Soc Trans (2005) 33 (6): 1427–1429.
Published: 26 October 2005
... an important method to study data analysis algorithms in systems biology. This approach is expected to be particularly important in comparing competing data analysis methods that require considerably different experimental setups. In that case, modelling may be the only way to be able to study...
Articles
Biochem Soc Trans (2005) 33 (3): 507–515.
Published: 01 June 2005
...O. Wolkenhauer; S.N. Sreenath; P. Wellstead; M. Ullah; K.-H. Cho A mathematical understanding of regulation, and, in particular, the role of feedback, has been central to the advance of the physical sciences and technology. In this article, the framework provided by systems biology is used to argue...
Articles
Biochem Soc Trans (2005) 33 (3): 503–506.
Published: 01 June 2005
...M.P. Williamson Systems biology describes the collection of a set of measurements on a system, integrated with a mathematical model of that system. The model and the measurements must be made together and refined iteratively, requiring close collaboration between biologists and modellers...
Articles
Biochem Soc Trans (2005) 33 (3): 539–542.
Published: 01 June 2005
... systems. I use models of the heart to demonstrate that we can now go all the way from individual genetic information (on mutations, for example) to exploring the consequences at a whole-organ level. Yes, let's celebrate the emergence of Systems Biology as a discipline. The challenge posed...
Articles
Biochem Soc Trans (2005) 33 (3): 516–519.
Published: 01 June 2005
...A. Cornish-Bowden; M.L. Cárdenas The first point to note about whether systems biology will work is that the essential idea of systems biology is not new: there has been interest in it, as well as efforts to apply it, since the middle of the 20th century. The difference now is that it has become...
Articles
Biochem Soc Trans (2005) 33 (3): 520–524.
Published: 01 June 2005
...D.B. Kell In answering the question ‘Systems Biology – will it work?’ (which it self-evidently has already), it is appropriate to highlight advances in philosophy, in new technique development and in novel findings. In terms of philosophy, we see that systems biology involves an iterative interplay...
Articles
Biochem Soc Trans (2003) 31 (6): 1503–1509.
Published: 01 December 2003
... and physical sciences involved in life sciences. The emergence of systems biology as a new area of research is evidence for these developments. Dynamic modelling and simulation of signal transduction pathways is an important theme in systems biology and is getting growing attention from researchers...
Articles
Biochem Soc Trans (2003) 31 (6): 1513–1515.
Published: 01 December 2003
... research directions. Unravelling Nature s Networks 1513 Petri Net representations in systems biology J.W. Pinney1, D.R. Westhead and G.A. McConkey Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K. Abstract The mathematical structures known as Petri Nets have recently become the focus...